Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells [0.03%]
空腹通过β-羟丁酸诱导的浆细胞耗竭抑制体液免疫记忆反应
Yiming Zhu,Baoshan Ding,Haimei Lv et al.
Yiming Zhu et al.
Humoral immunological memory mediated by memory B cells (MBCs) and long-lived plasma cells (LLPCs) is critical for sustained protection following infection or vaccination. LLPCs protect the hosts by secreting protective neutralizing antibod...
Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis [0.03%]
交感神经活化促进肥大细胞浸润加剧特应性皮炎
Xinyang Xie,Wenjing Jiang,Lerong Lun et al.
Xinyang Xie et al.
Emotional stress exacerbates atopic dermatitis (AD) and contributes to overall disease burden. While sympathetic nervous system (SNS) activity broadly interacts with emotional states, its role in skin immunity remains underexplored. Using a...
The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors [0.03%]
转录阻遏物Fli1通过在营养应激期间抑制细胞稳态来限制NK细胞在实体瘤中的存活
Jeong Hyun Ji,Wesley R Armstrong,Joey H Li et al.
Jeong Hyun Ji et al.
Tumor-infiltrating natural killer (NK) cells display reduced persistence and effector functions. Here, we examined the mechanisms underlying NK cell dysfunction in cancer. Gene expression analyses of matched tumor-infiltrating and tumor-adj...
Homeostatic maturation programs drive human cDC2s into a tolerogenic state [0.03%]
稳态成熟程序使人类cDC2s进入耐受状态
Mengmeng Lu,Runpeng Han,Hao Yang et al.
Mengmeng Lu et al.
Dendritic cells (DCs) serve as central regulators of immune activation and tolerance. While DC-mediated protective immunity is well established, the mechanisms underlying human peripheral tolerance remain unclear. Through the multi-omics an...
Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation [0.03%]
Caspase-4结合正曲率LPS膜激活非经典炎性小体
Jakub Began,Alexandra Boegli,Leonie Anton et al.
Jakub Began et al.
The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria. Caspase-4 activation also depends on several guanylate-binding proteins (GBPs)...
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading [0.03%]
局部抗体反馈在生发中心建立亲和力成熟的检查点并促进表位扩散
Yu Yan,Xuesong Wang,Zhenfei Xie et al.
Yu Yan et al.
Circulating antibodies from previous immune encounters impact subsequent humoral responses. Here, we investigated how local epitope-specific competition shapes ongoing germinal center (GC) responses by delivering an mRNA-LNP-encoded membran...
Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation [0.03%]
饮食限制期间激素介导的免疫重构确保宿主防御和全身葡萄糖保存
Luisa Menezes-Silva,Mingeum Jeong,Charles Carr et al.
Luisa Menezes-Silva et al.
Food shortages and infectious diseases were constant threats throughout mammalian evolution and often occurred simultaneously. When food availability is reduced, it is unclear how the host adapts to support glucose-demanding immune processe...
Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells [0.03%]
浆细胞样树突状细胞中通过染色质介导的I型干扰素产生的预见性调控
Nicholas M Adams,Aleksandra Galitsyna,Ioanna Tiniakou et al.
Nicholas M Adams et al.
Type I interferons (IFN-I), including IFN-β and multiple IFN-α subtypes, are key antiviral proteins encoded within a single large locus. Here, we studied how the chromatin organization of this locus controls cell-type-specific IFN-I respo...
Victor Bosteels,Sophie Janssens
Victor Bosteels
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zh...
Christopher A Polera,Alex M Jaeger
Christopher A Polera
Defining the antigen specificity of T cell receptors (TCRs) remains a significant barrier to understanding adaptive immunity in various pathologies. In this issue of Immunity, Gaglione et al. report the development of TCRAFT, a novel platfo...