Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
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The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria. Caspase-4 activation also depends on several guanylate-binding proteins (GBPs), which associate wi... ...
