Xiao Qin,Ferran Cardoso Rodriguez,Jahangir Sufi et al.
Xiao Qin et al.
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell fate, we performed a systema...
A genetic history of the Balkans from Roman frontier to Slavic migrations [0.03%]
从罗马边界到斯拉夫移民的巴尔干半岛的遗传历史
Iñigo Olalde,Pablo Carrión,Ilija Mikić et al.
Iñigo Olalde et al.
The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for human history. The Middle Danube was a crucial frontier and a crossroads for population and cultural movement. Here, we present genome-wide ...
SPLASH: A statistical, reference-free genomic algorithm unifies biological discovery [0.03%]
一种统计学的、无参的组学算法可统一度生物学发现
Kaitlin Chaung,Tavor Z Baharav,George Henderson et al.
Kaitlin Chaung et al.
Today's genomics workflows typically require alignment to a reference sequence, which limits discovery. We introduce a unifying paradigm, SPLASH (Statistically Primary aLignment Agnostic Sequence Homing), which directly analyzes raw sequenc...
Angus S Murphy,Alan M Jones
Angus S Murphy
An Arabidopsis cell-surface auxin receptor that mediates rapid elongation consists of transmembrane kinases (TMKs) and an auxin-binding co-receptor. Auxin-binding protein 1 (ABP1) is one identified TMK co-receptor, but abp1 mutants have no ...
Next-generation primate genomics: New genome assemblies unlock new questions [0.03%]
下一代灵长类基因组学：新的基因组组装引发新的问题
Genevieve Housman,Jenny Tung
Genevieve Housman
Nonhuman primates provide unique evolutionary and comparative insight into the human phenotype. Genome assemblies are now available for nearly half of the species in the primate order, expanding our understanding of genetic variation within...
Yiye Li,Can Di,Shijian Song et al.
Yiye Li et al.
Tumor-associated hydrocephalus (TAH) is a common and lethal complication of brain metastases. Although other factors beyond mechanical obstructions have been suggested, the exact mechanisms are unknown. Using single-nucleus RNA sequencing a...
An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling [0.03%]
一种选择性S-硝化蛋白质以调节胰岛素信号传导的酶
Hua-Lin Zhou,Zachary W Grimmett,Nicholas M Venetos et al.
Hua-Lin Zhou et al.
Acyl-coenzyme A (acyl-CoA) species are cofactors for numerous enzymes that acylate thousands of proteins. Here, we describe an enzyme that uses S-nitroso-CoA (SNO-CoA) as its cofactor to S-nitrosylate multiple proteins (SNO-CoA-assisted nit...
Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture [0.03%]
利用干细胞共培养解剖胚胎与副胚层谱系的相互作用
Yulei Wei,E Zhang,Leqian Yu et al.
Yulei Wei et al.
Embryogenesis necessitates harmonious coordination between embryonic and extraembryonic tissues. Although stem cells of both embryonic and extraembryonic origins have been generated, they are grown in different culture conditions. In this s...
Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis [0.03%]
I型干扰素驱动的易患结核病的早期细胞机制
Dmitri I Kotov,Ophelia V Lee,Stefan A Fattinger et al.
Dmitri I Kotov et al.
Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the cellular mechanisms underlying tuberculosis pathogenesis remain poorly u...
Temporally multiplexed imaging of dynamic signaling networks in living cells [0.03%]
活细胞中动态信号网络的时序图像复用技术
Yong Qian,Orhan T Celiker,Zeguan Wang et al.
Yong Qian et al.
Molecular signals interact in networks to mediate biological processes. To analyze these networks, it would be useful to image many signals at once, in the same living cell, using standard microscopes and genetically encoded fluorescent rep...