Insights and strategies for improving equity in graduate school admissions [0.03%]
关于改进研究生录取公平性的洞察与策略
Melissa Andrea Cadena,Cathy Amaya,Daisy Duan et al.
Melissa Andrea Cadena et al.
Applying to graduate school can be particularly challenging for students from historically minoritized backgrounds due to a hidden curriculum in the graduate admissions process. To address this issue, a team of volunteer STEM trainees estab...
RNA "COURIERs": Enabling synthetic cell-to-cell communication in human cells [0.03%]
RNA"信使"：在人类细胞中实现合成的细胞间通讯
Taek Kang,Leonidas Bleris
Taek Kang
The development of molecular couriers to selectively package, export, and recover RNA molecules within human cells is a significant challenge. In this issue of Cell, Horns et al.1 introduce cellular RNA exporters, termed COURIERs, that pack...
The calvaria stands alone: Unique aspects of the skull bone marrow-meninges border [0.03%]
颅骨骨髓-硬脑膜边界的独特之处
Sachin P Gadani,Peter A Calabresi
Sachin P Gadani
Channels connecting the skull bone marrow and the meninges have recently been discovered as a path for immune cell and molecule trafficking. In this issue of Cell, Kolabas, Kuemmerle, Perneczky, Förstera, and colleagues characterize these ...
Herpes simplex virus gene therapy for dystrophic epidermolysis bullosa (DEB) [0.03%]
单纯疱疹病毒基因治疗用于营养不良型大疱性表皮松解症(DEB)
Alberto L Epstein,Cornelia Haag-Molkenteller
Alberto L Epstein
The FDA has recently approved Krystal biotech's beremagene geperpavec (B-VEC, Vyjuvek) to treat the wounds of dystrophic epidermolysis bullosa (DEB) patients. This represents a giant step, not only toward the treatment of this devastating d...
The projection-specific signals that establish functionally segregated dopaminergic synapses [0.03%]
建立功能分离的多巴胺能突触的信号投影特定性
Akiko Terauchi,Patricia Yee,Erin M Johnson-Venkatesh et al.
Akiko Terauchi et al.
Dopaminergic projections regulate various brain functions and are implicated in many neuropsychiatric disorders. There are two anatomically and functionally distinct dopaminergic projections connecting the midbrain to striatum: nigrostriata...
Oliver Hahn,Aulden G Foltz,Micaiah Atkins et al.
Oliver Hahn et al.
Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of the mouse brain, profiling 1,076 samples from 15 regions acro...
Archival single-cell genomics reveals persistent subclones during DCIS progression [0.03%]
档案单细胞基因组学揭示了DCIS进展过程中持久存在的亚克隆群
Kaile Wang,Tapsi Kumar,Junke Wang et al.
Kaile Wang et al.
Ductal carcinoma in situ (DCIS) is a common precursor of invasive breast cancer. Our understanding of its genomic progression to recurrent disease remains poor, partly due to challenges associated with the genomic profiling of formalin-fixe...
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation [0.03%]
泛癌分析揭示了蛋白质调控的共同模式
Yifat Geffen,Shankara Anand,Yo Akiyama et al.
Yifat Geffen et al.
Post-translational modifications (PTMs) play key roles in regulating cell signaling and physiology in both normal and cancer cells. Advances in mass spectrometry enable high-throughput, accurate, and sensitive measurement of PTM levels to b...
Pan-cancer proteogenomics connects oncogenic drivers to functional states [0.03%]
泛癌蛋白质基因组学连接致癌驱动因素与功能状态
Yize Li,Eduard Porta-Pardo,Collin Tokheim et al.
Yize Li et al.
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer...
Daniel W Bayless,Chung-Ha O Davis,Renzhi Yang et al.
Daniel W Bayless et al.
Male sexual behavior is innate and rewarding. Despite its centrality to reproduction, a molecularly specified neural circuit governing innate male sexual behavior and reward remains to be characterized. We have discovered a developmentally ...