Martin Wilkinson,Yong Xu,Dev Thacker et al.
Martin Wilkinson et al.
Cryoelectron microscopy (cryo-EM) has provided unprecedented insights into amyloid fibril structures, including those associated with disease. However, these structures represent the endpoints of long assembly processes, and their relations...
LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons [0.03%]
LRRC37B是人类电压门控钠通道的修饰因子，并且影响皮层神经元轴突的兴奋性
Baptiste Libé-Philippot,Amélie Lejeune,Keimpe Wierda et al.
Baptiste Libé-Philippot et al.
The enhanced cognitive abilities characterizing the human species result from specialized features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B encodes a receptor expressed in human cortical pyramidal neur...
Paul J Farrell
Paul J Farrell
Autoimmune cross-reaction of specific antibodies to Epstein-Barr virus (EBV) has been associated with development of multiple sclerosis (MS). In this issue of Cell, Vietzen et al. identify additional immunological regulatory mechanisms that...
RAF-like protein kinases mediate a deeply conserved, rapid auxin response [0.03%]
类似RAF的蛋白激酶介导了快速反应的生长素应答这一古老机制
Andre Kuhn,Mark Roosjen,Sumanth Mutte et al.
Andre Kuhn et al.
The plant-signaling molecule auxin triggers fast and slow cellular responses across land plants and algae. The nuclear auxin pathway mediates gene expression and controls growth and development in land plants, but this pathway is absent fro...
Metabolic regulation of homologous recombination repair by MRE11 lactylation [0.03%]
MRE11乳酸化对同源重组修复的代谢调控
Yuping Chen,Jinhuan Wu,Linhui Zhai et al.
Yuping Chen et al.
Lactylation is a lactate-induced post-translational modification best known for its roles in epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous recombination (HR) protein, is lactylated at K673 by the CBP acetylt...
Super-enhancers include classical enhancers and facilitators to fully activate gene expression [0.03%]
超级增强子包括经典增强子和促进者以充分激活基因表达
Joseph W Blayney,Helena Francis,Alexandra Rampasekova et al.
Joseph W Blayney et al.
Super-enhancers are compound regulatory elements that control expression of key cell identity genes. They recruit high levels of tissue-specific transcription factors and co-activators such as the Mediator complex and contact target gene pr...
Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism [0.03%]
大麻素受体1- Arrestin复合物的快照揭示了偏向信号机制
Yu-Ying Liao,Huibing Zhang,Qingya Shen et al.
Yu-Ying Liao et al.
Cannabis activates the cannabinoid receptor 1 (CB1), which elicits analgesic and emotion regulation benefits, along with adverse effects, via Gi and β-arrestin signaling pathways. However, the lack of understanding of the mechanism of β-a...
Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics [0.03%]
基因组监测揭示了COVID-19大流行连接性的动态变化
Nathaniel L Matteson,Gabriel W Hassler,Ezra Kurzban et al.
Nathaniel L Matteson et al.
The maturation of genomic surveillance in the past decade has enabled tracking of the emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, for example, genomic data revealed that local epidemics varied ...
Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition [0.03%]
肠道共生原生动物的代谢多样性调节肠道免疫和跨界竞争
Elias R Gerrick,Soumaya Zlitni,Patrick T West et al.
Elias R Gerrick et al.
The microbiota influences intestinal health and physiology, yet the contributions of commensal protists to the gut environment have been largely overlooked. Here, we discover human- and rodent-associated parabasalid protists, revealing subs...
Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain [0.03%]
时空转录组揭示了发育中人脑的区域特化
Yanxin Li,Zhongqiu Li,Changliang Wang et al.
Yanxin Li et al.
Different functional regions of brain are fundamental for basic neurophysiological activities. However, the regional specification remains largely unexplored during human brain development. Here, by combining spatial transcriptomics (scSter...