Menopause-Biology, consequences, supportive care, and therapeutic options [0.03%]
围绝经期的发病机制、影响及治疗和护理建议
Susan R Davis,JoAnn Pinkerton,Nanette Santoro et al.
Susan R Davis et al.
Menopause is the cessation of ovarian function, with loss of reproductive hormone production and irreversible loss of fertility. It is a natural part of reproductive aging. The physiology of the menopause is complex and incompletely underst...
Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice [0.03%]
下丘脑-垂体-肾上腺轴应激通路抑制小鼠社交行为的神经环路及机制研究
Noelia Sofia de León Reyes,Paula Sierra Díaz,Ramon Nogueira et al.
Noelia Sofia de León Reyes et al.
Social preference, the decision to interact with one member of the same species over another, is critical to optimize social interactions. Thus, adult rodents favor interacting with novel conspecifics over familiar ones, but whether this so...
Retraction Notice to: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion [0.03%]
撤回 notice to: unc5和dcc家族受体细胞内结构域的配体调控型相互作用使netrin诱导的生长锥吸引转换为排斥反应
Kyonsoo Hong,Lindsay Hinck,Makoto Nishiyama et al.
Kyonsoo Hong et al.
Retraction of Publication
Cell. 2023 Sep 14;186(19):4256. DOI:10.1016/j.cell.2023.08.024 2023
Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets [0.03%]
家源H3N8禽流感病毒在雪貂之间的气溶胶传播性研究
Honglei Sun,Han Li,Qi Tong et al.
Honglei Sun et al.
H3N8 avian influenza viruses (AIVs) in China caused two confirmed human infections in 2022, followed by a fatal case reported in 2023. H3N8 viruses are widespread in chicken flocks; however, the zoonotic features of H3N8 viruses are poorly ...
Phage-assisted evolution and protein engineering yield compact, efficient prime editors [0.03%]
基于噬菌体的进化和蛋白质工程产生精简而高效的先导编辑系统
Jordan L Doman,Smriti Pandey,Monica E Neugebauer et al.
Jordan L Doman et al.
Prime editing enables a wide variety of precise genome edits in living cells. Here we use protein evolution and engineering to generate prime editors with reduced size and improved efficiency. Using phage-assisted evolution, we improved edi...
Biomarkers of aging for the identification and evaluation of longevity interventions [0.03%]
用于识别和评估长寿干预措施的衰老生物标志物
Mahdi Moqri,Chiara Herzog,Jesse R Poganik;Biomarkers of Aging Consortium;Jamie Justice et al.
Mahdi Moqri et al.
With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives...
Martin F Pera
Martin F Pera
The second week of embryonic development is a critical phase of the human life cycle and one that has been largely inaccessible to scientific investigation. Recent studies of human embryo models built from stem cells promise to yield dramat...
Birgit Sawitzki
Birgit Sawitzki
In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe i...
Bridge-building between communities: Imagining the future of biomedical autism research [0.03%]
架桥联结社群：构想生物医学自闭症研究的未来
Síofra Heraty,Alexandra Lautarescu,David Belton et al.
Síofra Heraty et al.
A paradigm shift in research culture is required to ease perceived tensions between autistic people and the biomedical research community. As a group of autistic and non-autistic scientists and stakeholders, we contend that through particip...
Structural basis for ion selectivity in potassium-selective channelrhodopsins [0.03%]
钾选择性通道视紫红质的离子选择机制的结构基础
Seiya Tajima,Yoon Seok Kim,Masahiro Fukuda et al.
Seiya Tajima et al.
KCR channelrhodopsins (K+-selective light-gated ion channels) have received attention as potential inhibitory optogenetic tools but more broadly pose a fundamental mystery regarding how their K+ selectivity is achieved. Here, we present 2.5...