XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells [0.03%]
XIST直接调节原始人类多能细胞中的X连锁基因和常染色体基因
Iris Dror,Tsotne Chitiashvili,Shawn Y X Tan et al.
Iris Dror et al.
X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of gene expression, wherein the long non-coding RNA XIST spreads across the X chromosome in cis to mediate gene silencing chromosome-wide. In female naive huma...
Cell at fifty [0.03%]
细胞学说五十年
The Cell Editorial Team
The Cell Editorial Team
Fifty years ago, Cell launched with the aspiration of becoming a journal of exciting biology. Today, we begin a year-long celebration of this momentous anniversary. But before we embark on our journey, we first reflect on Cell at fifty and ...
Editorial
Cell. 2024 Jan 4;187(1):1-2. DOI:10.1016/j.cell.2023.12.009 2024
Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus [0.03%]
东方马脑炎病毒利用VLDLR的结构和功能基础
Lucas J Adams,Saravanan Raju,Hongming Ma et al.
Lucas J Adams et al.
The very-low-density lipoprotein receptor (VLDLR) comprises eight LDLR type A (LA) domains and supports entry of distantly related alphaviruses, including Eastern equine encephalitis virus (EEEV) and Semliki Forest virus (SFV). Here, by res...
Cytoneme signaling provides essential contributions to mammalian tissue patterning [0.03%]
细胞纳米管信号对哺乳动物组织模式形成做出重要贡献
Eric T Hall,Miriam E Dillard,Elizabeth R Cleverdon et al.
Eric T Hall et al.
During development, morphogens pattern tissues by instructing cell fate across long distances. Directly visualizing morphogen transport in situ has been inaccessible, so the molecular mechanisms ensuring successful morphogen delivery remain...
Human inherited CCR2 deficiency underlies progressive polycystic lung disease [0.03%]
人类继承的CCR2缺陷导致进行性多囊肺病
Anna-Lena Neehus,Brenna Carey,Marija Landekic et al.
Anna-Lena Neehus et al.
We describe a human lung disease caused by autosomal recessive, complete deficiency of the monocyte chemokine receptor C-C motif chemokine receptor 2 (CCR2). Nine children from five independent kindreds have pulmonary alveolar proteinosis (...
Extracellular pectin-RALF phase separation mediates FERONIA global signaling function [0.03%]
胞外的果胶-RALF相分离介导FERONIA全局信号功能
Ming-Che James Liu,Fang-Ling Jessica Yeh,Robert Yvon et al.
Ming-Che James Liu et al.
The FERONIA (FER)-LLG1 co-receptor and its peptide ligand RALF regulate myriad processes for plant growth and survival. Focusing on signal-induced cell surface responses, we discovered that intrinsically disordered RALF triggers clustering ...
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma [0.03%]
基于时间的单细胞转录组学定义了胶质母细胞瘤中的免疫路径
Daniel Kirschenbaum,Ken Xie,Florian Ingelfinger et al.
Daniel Kirschenbaum et al.
Deciphering the cell-state transitions underlying immune adaptation across time is fundamental for advancing biology. Empirical in vivo genomic technologies that capture cellular dynamics are currently lacking. We present Zman-seq, a single...
Masato Tamari,Kate L Del Bel,Aaron M Ver Heul et al.
Masato Tamari et al.
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) an...
Automatic cell-type harmonization and integration across Human Cell Atlas datasets [0.03%]
人类细胞图谱数据集中自动细胞类型统一与整合
Chuan Xu,Martin Prete,Simone Webb et al.
Chuan Xu et al.
Harmonizing cell types across the single-cell community and assembling them into a common framework is central to building a standardized Human Cell Atlas. Here, we present CellHint, a predictive clustering tree-based tool to resolve cell-t...
Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [0.03%]
脆性X综合症中长突触基因的空間協同异染色质化
Thomas Malachowski,Keerthivasan Raanin Chandradoss,Ravi Boya et al.
Thomas Malachowski et al.
Short tandem repeat (STR) instability causes transcriptional silencing in several repeat expansion disorders. In fragile X syndrome (FXS), mutation-length expansion of a CGG STR represses FMR1 via local DNA methylation. Here, we find megaba...