Modular pooled discovery of synthetic knockin sequences to program durable cell therapies [0.03%]
模块化筛选合成敲入序列以编程持久性细胞疗法
Franziska Blaeschke,Yan Yi Chen,Ryan Apathy et al.
Franziska Blaeschke et al.
Chronic stimulation can cause T cell dysfunction and limit the efficacy of cellular immunotherapies. Improved methods are required to compare large numbers of synthetic knockin (KI) sequences to reprogram cell functions. Here, we developed ...
Complex effects of sequence variants on lipid levels and coronary artery disease [0.03%]
血脂水平和冠心病的序列变异复杂效应分析
Audunn S Snaebjarnarson,Anna Helgadottir,Gudny A Arnadottir et al.
Audunn S Snaebjarnarson et al.
Many sequence variants have additive effects on blood lipid levels and, through that, on the risk of coronary artery disease (CAD). We show that variants also have non-additive effects and interact to affect lipid levels as well as affectin...
Joan Massagué,Dean Sheppard
Joan Massagué
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, ph...
Samantha Joubran,Vijay G Sankaran
Samantha Joubran
Hematopoiesis requires balance between self-renewal of stem cells and differentiation into mature blood cells, orchestrated by pathways such as thrombopoietin signaling. In this issue of Cell, Tsutsumi et al. report the structure of the thr...
Rebekah Honce,Stacey Schultz-Cherry
Rebekah Honce
Avian influenza viruses continue to cross the species barrier and infect mammals. In this issue of Cell, Sun and colleagues demonstrate that viruses obtained from humans infected with an emergent avian H3N8 viruses exhibit increasing accumu...
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development [0.03%]
免疫细胞图谱揭示了人体巨噬细胞在胚胎发育期间的特征动态变化过程
Zeshuai Wang,Zhisheng Wu,Hao Wang et al.
Zeshuai Wang et al.
Macrophages are heterogeneous and play critical roles in development and disease, but their diversity, function, and specification remain inadequately understood during human development. We generated a single-cell RNA sequencing map of the...
Self-demixing of mRNA copies buffers mRNA:mRNA and mRNA:regulator stoichiometries [0.03%]
mRNA拷贝的自我解混平衡mRNA:mRNA和mRNA:调节物的摩尔比
Andrés H Cardona,Szilvia Ecsedi,Mokrane Khier et al.
Andrés H Cardona et al.
Cellular homeostasis requires the robust control of biomolecule concentrations, but how do millions of mRNAs coordinate their stoichiometries in the face of dynamic translational changes? Here, we identified a two-tiered mechanism controlli...
Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [0.03%]
由免疫特性间质细胞调控的早期妊娠时空新见解
Min Yang,Jennie Ong,Fanju Meng et al.
Min Yang et al.
Endometrial decidualization connecting embryo implantation and placentation is transient but essential for successful pregnancy, which, however, is not systematically investigated. Here, we use a scStereo-seq technology to spatially visuali...
Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants [0.03%]
血脑屏障的激素守门机制控制蚂蚁品级特异行为
Linyang Ju,Karl M Glastad,Lihong Sheng et al.
Linyang Ju et al.
Here, we reveal an unanticipated role of the blood-brain barrier (BBB) in regulating complex social behavior in ants. Using scRNA-seq, we find localization in the BBB of a key hormone-degrading enzyme called juvenile hormone esterase (Jhe),...
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle [0.03%]
基因操控Patescibacteria为研究微生物暗物质和附生生活方式提供机制见解
Yaxi Wang,Larry A Gallagher,Pia A Andrade et al.
Yaxi Wang et al.
Patescibacteria, also known as the candidate phyla radiation (CPR), are a diverse group of bacteria that constitute a disproportionately large fraction of microbial dark matter. Its few cultivated members, belonging mostly to Saccharibacter...