Influence of autozygosity on common disease risk across the phenotypic spectrum [0.03%]
外显子自交配对常见疾病易感性的影响
Daniel S Malawsky,Eva van Walree,Benjamin M Jacobs et al.
Daniel S Malawsky et al.
Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of the genome in runs of homozygosity (FROH) and common diseases in Genes & Health (n = ...
Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants [0.03%]
淀粉体沉积重新极化LAZY蛋白实现植物对重力的感知
Jiayue Chen,Renbo Yu,Na Li et al.
Jiayue Chen et al.
Gravity controls directional growth of plants, and the classical starch-statolith hypothesis proposed more than a century ago postulates that amyloplast sedimentation in specialized cells initiates gravity sensing, but the molecular mechani...
SARS-CoV-2 variants evolve convergent strategies to remodel the host response [0.03%]
新冠病毒变异体采用汇聚策略重塑宿主反应
Mehdi Bouhaddou,Ann-Kathrin Reuschl,Benjamin J Polacco et al.
Mehdi Bouhaddou et al.
SARS-CoV-2 variants of concern (VOCs) emerged during the COVID-19 pandemic. Here, we used unbiased systems approaches to study the host-selective forces driving VOC evolution. We discovered that VOCs evolved convergent strategies to remodel...
Malika Aid,Michaela Sciacca,Katherine McMahan et al.
Malika Aid et al.
The mpox outbreak of 2022-2023 involved rapid global spread in men who have sex with men. We infected 18 rhesus macaques with mpox by the intravenous, intradermal, and intrarectal routes and observed robust antibody and T cell responses fol...
Host traits shape virome composition and virus transmission in wild small mammals [0.03%]
宿主特性决定野生小哺乳动物的病毒组组成及病毒传播
Yan-Mei Chen,Shu-Jian Hu,Xian-Dan Lin et al.
Yan-Mei Chen et al.
Bats, rodents, and shrews are the most important animal sources of human infectious diseases. However, the evolution and transmission of viruses among them remain largely unexplored. Through the meta-transcriptomic sequencing of internal or...
Mathias Jucker,Lary C Walker
Mathias Jucker
Recent Aβ-immunotherapy trials have yielded the first clear evidence that removing aggregated Aβ from the brains of symptomatic patients can slow the progression of Alzheimer's disease. The clinical benefit achieved in these trials has be...
Stepwise emergence of the neuronal gene expression program in early animal evolution [0.03%]
早期动物进化中神经元基因表达程序的逐步出现
Sebastián R Najle,Xavier Grau-Bové,Anamaria Elek et al.
Sebastián R Najle et al.
The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals not only have nine morphologica...
CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms [0.03%]
CD1脂质组揭示脂质结合基序和基于大小的抗原展示机制
Shouxiong Huang,Adam Shahine,Tan-Yun Cheng et al.
Shouxiong Huang et al.
The CD1 system binds lipid antigens for display to T cells. Here, we solved lipidomes for the four human CD1 antigen-presenting molecules, providing a map of self-lipid display. Answering a basic question, the detection of >2,000 CD1-lipid ...
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA [0.03%]
THOR的致癌作用：一种保守的癌症/睾丸长链非编码RNA
Yasuyuki Hosono,Yashar S Niknafs,John R Prensner et al.
Yasuyuki Hosono et al.
Published Erratum
Cell. 2023 Sep 14;186(19):4254-4255. DOI:10.1016/j.cell.2023.08.025 2023
Kevin G Mark,SriDurgaDevi Kolla,Jacob D Aguirre et al.
Kevin G Mark et al.
Published Erratum
Cell. 2023 Sep 14;186(19):4252-4253. DOI:10.1016/j.cell.2023.08.006 2023