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期刊名:Cell

缩写:CELL

ISSN:0092-8674

e-ISSN:1097-4172

IF/分区:42.5/Q1

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共收录本刊相关文章索引9608
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Vahid Gazestani,Tushar Kamath,Naeem M Nadaf et al. Vahid Gazestani et al.
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical biopsies from living individuals with...
Xushen Xiong,Benjamin T James,Carles A Boix et al. Xushen Xiong et al.
Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here, we profile epigenomic and transcriptomic landscapes of 850...
Vishnu Dileep,Carles A Boix,Hansruedi Mathys et al. Vishnu Dileep et al.
Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to disrupt genome integrity. We used single-nucleus RNA-seq in hum...
Na Sun,Matheus B Victor,Yongjin P Park et al. Na Sun et al.
Altered microglial states affect neuroinflammation, neurodegeneration, and disease but remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes and epigenomes across 443 human subjects and diverse Alzheimer...
Hansruedi Mathys,Zhuyu Peng,Carles A Boix et al. Hansruedi Mathys et al.
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the molecular and cellular mechanisms underlying cognitive impairment remain poorly understood. To address this, we generated a single-cell transcriptomic atlas of...
Ziyu Lu,Melissa Zhang,Jasper Lee et al. Ziyu Lu et al.
Progenitor cells are critical in preserving organismal homeostasis, yet their diversity and dynamics in the aged brain remain underexplored. We introduced TrackerSci, a single-cell genomic method that combines newborn cell labeling and comb...
Wenjie Luo,Wenhui Qu,Li Gan Wenjie Luo
Deciphering cellular changes in Alzheimer's disease (AD) using large cohorts with defined clinical stages is essential for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies harnessed the power of ...
Shanhe Yu,Yingni Lin,Yong Li et al. Shanhe Yu et al.
SARS-CoV-2 primary strain-based vaccination exerts a protective effect against Omicron variants-initiated infection, symptom occurrence, and disease severity in a booster-dependent manner. Yet, the underlying mechanisms remain unclear. Duri...
Roeltje R Maas,Klara Soukup,Nadine Fournier et al. Roeltje R Maas et al.
Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in substantial numbers. However, their precise functions in different cancer types remain incompletely understood, including in the brain microenviron...