Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity [0.03%]
小分子GSDMD激动剂可激活肿瘤抗肿瘤免疫且无毒性效应
Pietro Fontana,Gang Du,Ying Zhang et al.
Pietro Fontana et al.
Gasdermin-mediated inflammatory cell death (pyroptosis) can activate protective immunity in immunologically cold tumors. Here, we performed a high-throughput screen for compounds that could activate gasdermin D (GSDMD), which is expressed w...
TGF-β and RAS jointly unmask primed enhancers to drive metastasis [0.03%]
TGF-β和RAS联合激活预备增强子以驱动转移性癌的发展
Jun Ho Lee,Francisco J Sánchez-Rivera,Lan He et al.
Jun Ho Lee et al.
Epithelial-to-mesenchymal transitions (EMTs) and extracellular matrix (ECM) remodeling are distinct yet important processes during carcinoma invasion and metastasis. Transforming growth factor β (TGF-β) and RAS, signaling through SMAD and...
Hellmut G Augustin,Gou Young Koh
Hellmut G Augustin
The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endo...
Carlise Sorenson,Katarzyna P Adamala
Carlise Sorenson
Building biological computers is one of the most intensively pursued goals of modern synthetic biology. The new TriLoS tristate-based logic synthesis platform, published in this issue of Cell, offers a long-awaited solution to scale up the ...
Tian-Li Wang,Ie-Ming Shih
Tian-Li Wang
Homologous-recombination deficiency in DNA repair characterizes a unique group of cancers that are vulnerable to PARP inhibitors and cytotoxic chemotherapy. In this issue of Cell, Luo et al., demonstrated that this genetic attribute in canc...
Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases [0.03%]
现成的CAR-T细胞有望对自身免疫病的治疗产生范式转变的效果
Daniel J Baker,Carl H June
Daniel J Baker
Early reports suggest that chimeric antigen receptor (CAR)-T therapy has remarkable potential for treating autoimmune disease. Current approaches rely on autologous CAR-T cells, creating a bottleneck to the broad deployment of this therapy....
Hiten D Madhani
Hiten D Madhani
Epigenetic inheritance of heterochromatin requires transfer of parental H3-H4 tetramers to both daughter duplexes during replication. Three recent papers exploit yeast genetics coupled to inheritance assays and AlphaFold2-multimer predictio...
Brian S Kim
Brian S Kim
In defying conventional views that dismissed itch as trivial, I persisted in studying basophils and ILC2s in human skin and atopic dermatitis. My research on JAK inhibitors for itch ultimately led to FDA-approved drugs. This is my story of ...
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates [0.03%]
比较改良型安卡拉痘病毒疫苗和信使rna疫苗预防类猴痘病毒感染的保护效果研究（英文）
Eric M Mucker,Alec W Freyn,Sandra L Bixler et al.
Eric M Mucker et al.
In 2022, mpox virus (MPXV) spread worldwide, causing 99,581 mpox cases in 121 countries. Modified vaccinia Ankara (MVA) vaccine use reduced disease in at-risk populations but failed to deliver complete protection. Lag in manufacturing and d...
Comparative Study
Cell. 2024 Oct 3;187(20):5540-5553.e10. DOI:10.1016/j.cell.2024.08.043 2024
Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome [0.03%]
来自2500种食品的未被探索的微生物多样性及其与人类微生物组的关系
Niccolò Carlino,Aitor Blanco-Míguez,Michal Punčochář et al.
Niccolò Carlino et al.
Complex microbiomes are part of the food we eat and influence our own microbiome, but their diversity remains largely unexplored. Here, we generated the open access curatedFoodMetagenomicData (cFMD) resource by integrating 1,950 newly seque...