A widely distributed gene cluster compensates for uricase loss in hominids [0.03%]
一个广泛分布的基因群可弥补类人猿中的尿酸酶丢失
Yuanyuan Liu,J Bryce Jarman,Yen S Low et al.
Yuanyuan Liu et al.
Published Erratum
Cell. 2023 Sep 28;186(20):4472-4473. DOI:10.1016/j.cell.2023.08.036 2023
Early Alzheimer's disease pathology in human cortex involves transient cell states [0.03%]
人类皮层早期阿尔茨海默病病理特征涉及细胞的瞬时状态
Vahid Gazestani,Tushar Kamath,Naeem M Nadaf et al.
Vahid Gazestani et al.
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical biopsies from living individuals with...
Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion [0.03%]
表观基因组分析揭示阿尔茨海默病的因果变异和表观基因组退化
Xushen Xiong,Benjamin T James,Carles A Boix et al.
Xushen Xiong et al.
Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here, we profile epigenomic and transcriptomic landscapes of 850...
Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration [0.03%]
神经元DNA双链断裂导致神经退行性疾病中的基因组结构变异和三维基因组破坏
Vishnu Dileep,Carles A Boix,Hansruedi Mathys et al.
Vishnu Dileep et al.
Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to disrupt genome integrity. We used single-nucleus RNA-seq in hum...
Na Sun,Matheus B Victor,Yongjin P Park et al.
Na Sun et al.
Altered microglial states affect neuroinflammation, neurodegeneration, and disease but remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes and epigenomes across 443 human subjects and diverse Alzheimer...
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology [0.03%]
单细胞图谱揭示了高认知功能、痴呆和对阿尔茨海默病病理的抵抗力的相关性
Hansruedi Mathys,Zhuyu Peng,Carles A Boix et al.
Hansruedi Mathys et al.
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the molecular and cellular mechanisms underlying cognitive impairment remain poorly understood. To address this, we generated a single-cell transcriptomic atlas of...
Tracking cell-type-specific temporal dynamics in human and mouse brains [0.03%]
追踪人脑和小鼠脑细胞类型特异性的时间动力学变化
Ziyu Lu,Melissa Zhang,Jasper Lee et al.
Ziyu Lu et al.
Progenitor cells are critical in preserving organismal homeostasis, yet their diversity and dynamics in the aged brain remain underexplored. We introduced TrackerSci, a single-cell genomic method that combines newborn cell labeling and comb...
Wenjie Luo,Wenhui Qu,Li Gan
Wenjie Luo
Deciphering cellular changes in Alzheimer's disease (AD) using large cohorts with defined clinical stages is essential for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies harnessed the power of ...
Systemic immune profiling of Omicron-infected subjects inoculated with different doses of inactivated virus vaccine [0.03%]
不同剂量灭活疫苗接种者感染奥密克戎病毒的系统性免疫反应谱分析
Shanhe Yu,Yingni Lin,Yong Li et al.
Shanhe Yu et al.
SARS-CoV-2 primary strain-based vaccination exerts a protective effect against Omicron variants-initiated infection, symptom occurrence, and disease severity in a booster-dependent manner. Yet, the underlying mechanisms remain unclear. Duri...
The local microenvironment drives activation of neutrophils in human brain tumors [0.03%]
人类脑肿瘤中的局部微环境驱动中性粒细胞活化
Roeltje R Maas,Klara Soukup,Nadine Fournier et al.
Roeltje R Maas et al.
Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in substantial numbers. However, their precise functions in different cancer types remain incompletely understood, including in the brain microenviron...