A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes [0.03%]
发育梯度揭示了单子叶球根植物中真核毒素的生物合成途径
Niraj Mehta,Yifan Meng,Richard Zare et al.
Niraj Mehta et al.
Numerous eukaryotic toxins that accumulate in geophytic plants are valuable in the clinic, yet their biosynthetic pathways have remained elusive. A notable example is the >150 Amaryllidaceae alkaloids (AmAs), including galantamine, an FDA-a...
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function [0.03%]
利用模版聚合来降解致病性tau聚集体并改善运动功能
Lauren V C Miller,Guido Papa,Marina Vaysburd et al.
Lauren V C Miller et al.
Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and removing aggregates, but not the functional protein, is a considerable therapeutic challenge. Here, we describe a therapeutic strategy called "RING-Bait," ...
Yuanhan Yang,Xiaoyong Lu,Ning Liu et al.
Yuanhan Yang et al.
In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histolog...
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival [0.03%]
TEX264通过促进DNA修复和细胞存活来驱动DNA损伤的选择性自噬
Pauline Lascaux,Gwendoline Hoslett,Sara Tribble et al.
Pauline Lascaux et al.
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of DNA lesions. We discovered that lysosomes proce...
Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics [0.03%]
单细胞基因组学揭示的痴呆共患病和特异性通路
Jessica E Rexach,Yuyan Cheng,Lawrence Chen et al.
Jessica E Rexach et al.
The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNA-seq and ATAC-seq in Alzheimer's disease (AD), frontotempo...
Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles [0.03%]
利用蛋白脂质载体安全有效地进行体内DNA和RNA输送
Douglas W Brown,Ping Wee,Prakash Bhandari et al.
Douglas W Brown et al.
Genetic medicines show promise for treating various diseases, yet clinical success has been limited by tolerability, scalability, and immunogenicity issues of current delivery platforms. To overcome these, we developed a proteolipid vehicle...
Yifan Dai,Zhengqing Zhou,Wen Yu et al.
Yifan Dai et al.
Control of the electrochemical environment in living cells is typically attributed to ion channels. Here, we show that the formation of biomolecular condensates can modulate the electrochemical environment in bacterial cells, which affects ...
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket [0.03%]
通过保守的隐蔽口袋靶向Ras、Rho和Rab家族GTP酶
Johannes Morstein,Victoria Bowcut,Micah Fernando et al.
Johannes Morstein et al.
The family of Ras-like GTPases consists of over 150 different members, regulated by an even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs) that comprise cellular switch networks that govern cell motil...
Haowu Jiang,Huan Cui,Mengyu Chen et al.
Haowu Jiang et al.
Sneezing and coughing are primary symptoms of many respiratory viral infections and allergies. It is generally assumed that sneezing and coughing involve common sensory receptors and molecular neurotransmission mechanisms. Here, we show tha...
Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy [0.03%]
衰老黑色素瘤肿瘤微环境的性别差异影响侵袭和靶向治疗抗性
Yash Chhabra,Mitchell E Fane,Sneha Pramod et al.
Yash Chhabra et al.
There is documented sex disparity in cutaneous melanoma incidence and mortality, increasing disproportionately with age and in the male sex. However, the underlying mechanisms remain unclear. While biological sex differences and inherent im...