Generative replay underlies compositional inference in the hippocampal-prefrontal circuit [0.03%]
生成再现是海马-前额叶回路组成推理的基础
Philipp Schwartenbeck,Alon Baram,Yunzhe Liu et al.
Philipp Schwartenbeck et al.
Human reasoning depends on reusing pieces of information by putting them together in new ways. However, very little is known about how compositional computation is implemented in the brain. Here, we ask participants to solve a series of pro...
Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8 [0.03%]
α病毒受体MXRA8的脊椎动物纲特异性结合模式
Ofer Zimmerman,Maxwell I Zimmerman,Saravanan Raju et al.
Ofer Zimmerman et al.
MXRA8 is a receptor for chikungunya (CHIKV) and other arthritogenic alphaviruses with mammalian hosts. However, mammalian MXRA8 does not bind to alphaviruses that infect humans and have avian reservoirs. Here, we show that avian, but not ma...
Dirk Mossmann,Christoph Müller,Sujin Park et al.
Dirk Mossmann et al.
Metabolic reprogramming is a hallmark of cancer. However, mechanisms underlying metabolic reprogramming and how altered metabolism in turn enhances tumorigenicity are poorly understood. Here, we report that arginine levels are elevated in m...
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells [0.03%]
减轻临床CRISPR-Cas9工程T细胞中染色体的丢失
Connor A Tsuchida,Nadav Brandes,Raymund Bueno et al.
Connor A Tsuchida et al.
CRISPR-Cas9 genome editing has enabled advanced T cell therapies, but occasional loss of the targeted chromosome remains a safety concern. To investigate whether Cas9-induced chromosome loss is a universal phenomenon and evaluate its clinic...
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9 [0.03%]
SND1结合SARS-CoV-2负链RNA并通过NSP9促进病毒RNA合成
Nora Schmidt,Sabina Ganskih,Yuanjie Wei et al.
Nora Schmidt et al.
Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically identified proteins bound to genomic and subgenomic SARS-CoV-2...
Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement [0.03%]
表观遗传平衡确保MLL扩增和重排的机制控制
Zach H Gray,Damayanti Chakraborty,Reuben R Duttweiler et al.
Zach H Gray et al.
MLL/KMT2A amplifications and translocations are prevalent in infant, adult, and therapy-induced leukemia. However, the molecular contributor(s) to these alterations are unclear. Here, we demonstrate that histone H3 lysine 9 mono- and di-met...
A disordered region controls cBAF activity via condensation and partner recruitment [0.03%]
无序区域通过浓缩和募集配体控制cBAF活性
Ajinkya Patil,Amy R Strom,Joao A Paulo et al.
Ajinkya Patil et al.
Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear protein content. The prevailing dogma is that IDRs engage in non-specific interactions because they are poorly constrained by evolutionary selection. He...
An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis [0.03%]
基于深度突变扫描和结构分析的AsCas12f衍生的小型基因组编辑工具
Tomohiro Hino,Satoshi N Omura,Ryoya Nakagawa et al.
Tomohiro Hino et al.
SpCas9 and AsCas12a are widely utilized as genome-editing tools in human cells. However, their relatively large size poses a limitation for delivery by cargo-size-limited adeno-associated virus (AAV) vectors. The type V-F Cas12f from Acidib...
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth [0.03%]
出生后黏膜和系统对SARS-CoV-2免疫的多组学分析
Florian Wimmers,Allison R Burrell,Yupeng Feng et al.
Florian Wimmers et al.
The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants and young childr...
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells [0.03%]
合成Par极性诱导非极化哺乳动物细胞的细胞骨架不对称性
Joseph L Watson,Lara K Krüger,Ariel J Ben-Sasson et al.
Joseph L Watson et al.
Polarized cells rely on a polarized cytoskeleton to function. Yet, how cortical polarity cues induce cytoskeleton polarization remains elusive. Here, we capitalized on recently established designed 2D protein arrays to ectopically engineer ...