Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants [0.03%]
精神分裂症相关非编码遗传变异的功能大规模并行分析
Christine K Rummel,Miriam Gagliardi,Ruhel Ahmad et al.
Christine K Rummel et al.
Schizophrenia (SCZ) is a highly heritable mental disorder with thousands of associated genetic variants located mostly in the noncoding space of the genome. Translating these associations into insights regarding the underlying pathomechanis...
A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells [0.03%]
一种具有高克隆条形码多样性的小鼠模型 用于单细胞中联合谱系、转录组和表观基因组分析
Li Li,Sarah Bowling,Sean E McGeary et al.
Li Li et al.
Cellular lineage histories and their molecular states encode fundamental principles of tissue development and homeostasis. Current lineage-recording mouse models have insufficient barcode diversity and single-cell lineage coverage for profi...
Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling [0.03%]
Wnt分子生成、分泌及其特异信号转导的分子基础
Xiaofeng Qi,Qinli Hu,Nadia Elghobashi-Meinhardt et al.
Xiaofeng Qi et al.
Wnt proteins are enzymatically lipidated by Porcupine (PORCN) in the ER and bind to Wntless (WLS) for intracellular transport and secretion. Mechanisms governing the transfer of these low-solubility Wnts from the ER to the extracellular spa...
Andrea C Wong,Ashwarya S Devason,Iboro C Umana et al.
Andrea C Wong et al.
Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated to explain the eti...
Accelerating Alzheimer's therapeutic development: The past and future of clinical trials [0.03%]
阿尔茨海默病的药物研发：临床试验的经验与未来展望
Adam L Boxer,Reisa Sperling
Adam L Boxer
Alzheimer's disease (AD) research has entered a new era with the recent positive phase 3 clinical trials of the anti-Aβ antibodies lecanemab and donanemab. Why did it take 30 years to achieve these successes? Developing potent therapies fo...
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes [0.03%]
无核和有丝分裂CDK/ cyclin复合物的胞质分裂周期
Anand Bakshi,Fabio Echegaray Iturra,Andrew Alamban et al.
Anand Bakshi et al.
Cytoplasmic divisions are thought to rely on nuclear divisions and mitotic signals. We demonstrate in Drosophila embryos that cytoplasm can divide repeatedly without nuclei and mitotic CDK/cyclin complexes. Cdk1 normally slows an otherwise ...
Dor Russ,Connor R Fitzpatrick,Paulo J P L Teixeira et al.
Dor Russ et al.
Plant-associated microbiota can extend plant immune system function, improve nutrient acquisition and availability, and alleviate abiotic stresses. Thus, naturally beneficial microbial therapeutics are enticing tools to improve plant produc...
Marcin J Suskiewicz,Evgeniia Prokhorova,Johannes G M Rack et al.
Marcin J Suskiewicz et al.
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent emergence of new technologies to study ADP-ribosylation has r...
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability [0.03%]
经典RPA和替代RPA在疾病相关串联CAG重复序列不稳定性中的拮抗作用
Terence Gall-Duncan,Jennifer Luo,Carla-Marie Jurkovic et al.
Terence Gall-Duncan et al.
Expansions of repeat DNA tracts cause >70 diseases, and ongoing expansions in brains exacerbate disease. During expansion mutations, single-stranded DNAs (ssDNAs) form slipped-DNAs. We find the ssDNA-binding complexes canonical replication ...
Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas [0.03%]
拟南芥近缘种间杂交的生殖障碍及解除机制
Zijun Lan,Zihan Song,Zhijuan Wang et al.
Zijun Lan et al.
Pollen-pistil interactions establish interspecific/intergeneric pre-zygotic hybridization barriers in plants. The rejection of undesired pollen at the stigma is crucial to avoid outcrossing but can be overcome with the support of mentor pol...