PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome [0.03%]
PNMA2形成与副肿瘤性神经综合征相关的免疫原性无包膜病毒样衣壳
Junjie Xu,Simon Erlendsson,Manvendra Singh et al.
Junjie Xu et al.
The paraneoplastic Ma antigen (PNMA) proteins are associated with cancer-induced paraneoplastic syndromes that present with an autoimmune response and neurological symptoms. Why PNMA proteins are associated with this severe autoimmune disea...
Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice [0.03%]
链球菌促进小鼠胃炎症、萎缩和肿瘤的发生
Kaili Fu,Alvin Ho Kwan Cheung,Chi Chun Wong et al.
Kaili Fu et al.
Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with gastric cancer (GC). Here, we show that S. anginosus colonized the mouse stomach and induced acute gastritis. S. anginosus infection spontaneously in...
A 25-year odyssey of genomic technology advances and structural variant discovery [0.03%]
基因组技术进步及结构变异发现25年历程探索
David Porubsky,Evan E Eichler
David Porubsky
This perspective focuses on advances in genome technology over the last 25 years and their impact on germline variant discovery within the field of human genetics. The field has witnessed tremendous technological advances from microarrays t...
Girak Kim,Zuojia Chen,Jian Li et al.
Girak Kim et al.
The gut and liver are recognized to mutually communicate through the biliary tract, portal vein, and systemic circulation. However, it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy and transcri...
Gut complement induced by the microbiota combats pathogens and spares commensals [0.03%]
微生物群诱导的肠道补体抗病原菌而饶过共生菌
Meng Wu,Wen Zheng,Xinyang Song et al.
Meng Wu et al.
Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a functioning complement system on intestinal mucosal surfaces. Herein, we report the local ...
Ningning Zhang,Wenwen Tang,Lidiane Torres et al.
Ningning Zhang et al.
RNAs localizing to the outer cell surface have been recently identified in mammalian cells, including RNAs with glycan modifications known as glycoRNAs. However, the functional significance of cell surface RNAs and their production are poor...
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme [0.03%]
DNA指导的转录因子协同作用塑造面部和肢体间充质结构
Seungsoo Kim,Ekaterina Morgunova,Sahin Naqvi et al.
Seungsoo Kim et al.
Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF cooperativity. Although in vitro studies suggest tha...
Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity [0.03%]
DGK5介导的PA爆发的双重磷酸化调节植物免疫中的ROS
Liang Kong,Xiyu Ma,Chao Zhang et al.
Liang Kong et al.
Phosphatidic acid (PA) and reactive oxygen species (ROS) are crucial cellular messengers mediating diverse signaling processes in metazoans and plants. How PA homeostasis is tightly regulated and intertwined with ROS signaling upon immune e...
Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling [0.03%]
使用基于PDMS的微流控芯片组件进行冷冻电镜的时间分辨率及其在研究HflX介导的核糖体循环中的应用
Sayan Bhattacharjee,Xiangsong Feng,Suvrajit Maji et al.
Sayan Bhattacharjee et al.
The rapid kinetics of biological processes and associated short-lived conformational changes pose a significant challenge in attempts to structurally visualize biomolecules during a reaction in real time. Conventionally, on-pathway intermed...
Complement in breast milk modifies offspring gut microbiota to promote infant health [0.03%]
母乳中的补体可改变后代的肠道微生物群以促进婴儿健康
Dongqing Xu,Siyu Zhou,Yue Liu et al.
Dongqing Xu et al.
Breastfeeding offers demonstrable benefits to newborns and infants by providing nourishment and immune protection and by shaping the gut commensal microbiota. Although it has been appreciated for decades that breast milk contains complement...