Nina Ripin,Roy Parker
Nina Ripin
Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP granules are implicated in many aspects of RNA physiology, but in m...
Daphne R Goring
Daphne R Goring
Mate selection in flowering plants can occur very rapidly after male pollen contact on the female pistil, but the cellular regulators driving this process were poorly understood. In this issue of Cell, Lan et al. have discovered the compone...
Do mammals have menopause? [0.03%]
哺乳动物会绝经吗？
Ivana Winkler,Angela Goncalves
Ivana Winkler
Semantics and lack of data have clouded our understanding about menopause in non-human mammals. The traditional definition of menopause based on the last menstrual bleed is limited and hinders cross-species comparison. Here, we redefine it ...
Nutrient-regulated control of lysosome function by signaling lipid conversion [0.03%]
信号脂质转化调控营养控制溶酶体功能
Michael Ebner,Dmytro Puchkov,Orestes López-Ortega et al.
Michael Ebner et al.
Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling and the catabolic turnover of macromolecules. How these janus-faced activities are regulated in response to cellular nutrient status is poorly under...
Matthijs Meijers,Denis Ruchnewitz,Jan Eberhardt et al.
Matthijs Meijers et al.
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of genetic clades. New variants show intrinsic changes, notably increased transmissibility, and antigenic changes that reduce cross-immunity induced by prev...
Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria [0.03%]
MCTS1介导的JAK2翻译调控对于IFN-γ抗分枝杆菌免疫是必需的
Jonathan Bohlen,Qinhua Zhou,Quentin Philippot et al.
Jonathan Bohlen et al.
Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with mycobacterial disease from kindreds of different ancestries (from China, Finla...
Richa Mishra,Melanie Hannebelle,Vishal P Patil et al.
Richa Mishra et al.
Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in alveolar cells contribute to suppression of innate immune ...
De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking [0.03%]
基于原位冷冻电镜断层扫描和AlphaFold2对接的哺乳动物精子从头蛋白鉴定
Zhen Chen,Momoko Shiozaki,Kelsey M Haas et al.
Zhen Chen et al.
To understand the molecular mechanisms of cellular pathways, contemporary workflows typically require multiple techniques to identify proteins, track their localization, and determine their structures in vitro. Here, we combined cellular cr...
Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo [0.03%]
结合液体活检蛋白质组学和人工智能发现眼衰老和疾病的体内细胞驱动因素
Julian Wolf,Ditte K Rasmussen,Young Joo Sun et al.
Julian Wolf et al.
Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and brain, because tissue biopsies would cause serious damage. We resolve this proble...
Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors [0.03%]
补体受体的过敏毒素结合、激活和信号偏向性的分子基础
Manish K Yadav,Jagannath Maharana,Ravi Yadav et al.
Manish K Yadav et al.
The complement system is a critical part of our innate immune response, and the terminal products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and pathophysiological responses primarily via two GPCRs, C3aR and C5aR...