Diana R Dou,Yanding Zhao,Julia A Belk et al.
Diana R Dou et al.
Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly i...
Susu Chen,Yi Liu,Ziyue Aiden Wang et al.
Susu Chen et al.
Behavior relies on activity in structured neural circuits that are distributed across the brain, but most experiments probe neurons in a single area at a time. Using multiple Neuropixels probes, we recorded from multi-regional loops connect...
Integrating cellular electron microscopy with multimodal data to explore biology across space and time [0.03%]
整合细胞电子显微镜与多模式数据以探索时空生物学
Caitlyn L McCafferty,Sven Klumpe,Rommie E Amaro et al.
Caitlyn L McCafferty et al.
Biology spans a continuum of length and time scales. Individual experimental methods only glimpse discrete pieces of this spectrum but can be combined to construct a more holistic view. In this Review, we detail the latest advancements in v...
Martin Beck,Roberto Covino,Inga Hänelt et al.
Martin Beck et al.
Determining the structure and mechanisms of all individual functional modules of cells at high molecular detail has often been seen as equal to understanding how cells work. Recent technical advances have led to a flush of high-resolution s...
Tanja Kortemme
Tanja Kortemme
Methods from artificial intelligence (AI) trained on large datasets of sequences and structures can now "write" proteins with new shapes and molecular functions de novo, without starting from proteins found in nature. In this Perspective, I...
Edward B Miller,Howook Hwang,Mee Shelley et al.
Edward B Miller et al.
High-quality predicted structures enable structure-based approaches to an expanding number of drug discovery programs. We propose that by utilizing free energy perturbation (FEP), predicted structures can be confidently employed to achieve ...
James S Fraser,Mark A Murcko
James S Fraser
Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges: interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling intera...
In November 2023, structural biologists from different countries and different disciplines gathered at the Cell Symposium: Structural biology from the nanoscale to cellular mesoscale to discuss recent breakthroughs, including structures of ...
Cell Editorial Team
Cell Editorial Team
Continuing the celebration of Cell's 50th anniversary, this Focus Issue is an ode to the field of Structural Biology. We present Leading Edge articles highlighting specific approaches and insights that this field offers to answer fundamenta...
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion [0.03%]
SMARCAL1是先天免疫信号和PD-L1表达的双重调节因子，可促进肿瘤免疫逃逸
Giuseppe Leuzzi,Alessandro Vasciaveo,Angelo Taglialatela et al.
Giuseppe Leuzzi et al.
Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection. However, cancer cells often evade these responses by overexpressing immune checkpoint regulators, such as PD-L1. Here, we identify the SN...