Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development [0.03%]
母乳喂养决定微生物定植程序并指导健康呼吸道发育
Liat Shenhav,Kelsey Fehr,Myrtha E Reyna et al.
Liat Shenhav et al.
Breastfeeding and microbial colonization during infancy occur within a critical time window for development, and both are thought to influence the risk of respiratory illness. However, the mechanisms underlying the protective effects of bre...
C Patrick Lusk,Megan C King
C Patrick Lusk
Nuclear pore complexes are massive protein gateways that control molecular exchange between the nucleus and cytoplasm. In this issue of Cell, Singh et al. provide the first high-resolution views of the elusive nuclear basket, which extends ...
A prokaryotic Argonaute protein recruits a helicase-nuclease to degrade invading plasmids [0.03%]
一种原核Argonaute蛋白通过招募解旋酶-核酸酶来降解入侵质粒
Dmitriy Ignatov,Vivekanandan Shanmuganathan,Emmanuelle Charpentier
Dmitriy Ignatov
DdmDE is a novel plasmid defense system that was discovered in the seventh pandemic Vibrio cholerae strain of the biotype O1 EI Tor. In this issue of Cell, Yang and coworkers reveal the mechanisms underlying the assembly and activation of t...
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s? [0.03%]
探究真核生物中的RNA引导的DNA内切酶：FanZ-样系统是CRISPR-Cas12系统的同源系统吗？
Satoshi N Omura,Osamu Nureki
Satoshi N Omura
Fanzors are recently characterized RNA-guided DNA endonucleases found in eukaryotic organisms. In this issue of Cell, Xu, Saito et al. reveal the structural diversity of Fanzors and identify key features shared with TnpB and Cas12 proteins,...
Catharine Adams,A Pedro Gonçalves,Sally Warring et al.
Catharine Adams et al.
The world of microbes is diverse, but the majority of these fascinating organisms are not as famous (or perhaps infamous) as their pathogenic counterparts. Cell highlights six scientists whose work addresses some of the most fundamental que...
Scientists' call to action: Microbes, planetary health, and the Sustainable Development Goals [0.03%]
科学家的呼吁：微生物、行星健康与可持续发展目标
Thomas W Crowther,Rino Rappuoli,Cinzia Corinaldesi et al.
Thomas W Crowther et al.
Microorganisms, including bacteria, archaea, viruses, fungi, and protists, are essential to life on Earth and the functioning of the biosphere. Here, we discuss the key roles of microorganisms in achieving the United Nations Sustainable Dev...
Transforming vaccinology [0.03%]
疫苗学的变革
Rino Rappuoli,Galit Alter,Bali Pulendran
Rino Rappuoli
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global consciousness, emphasizing the vital role of vaccines as transformative public health tools. The impact of vaccines was recently acknowledged by the awar...
Modern microbiology: Embracing complexity through integration across scales [0.03%]
现代微生物学：通过多尺度整合来迎接复杂性挑战
A Murat Eren,Jillian F Banfield
A Murat Eren
Microbes were the only form of life on Earth for most of its history, and they still account for the vast majority of life's diversity. They convert rocks to soil, produce much of the oxygen we breathe, remediate our sewage, and sustain agr...
Gerald Mboowa,Sofonias K Tessema,Alan Christoffels et al.
Gerald Mboowa et al.
Rapid expansion of pathogen sequencing capacity in Africa has led to a paradigm shift from relying on others to locally generating genomic data and sharing it with the global community. However, several barriers remain to be unlocked for ti...
Edward C Holmes,Florian Krammer,Felicia D Goodrum
Edward C Holmes
Virology has made enormous advances in the last 50 years but has never faced such scrutiny as it does today. Herein, we outline some of the major advances made in virology during this period, particularly in light of the COVID-19 pandemic, ...