Tom van der Valk,Love Dalèn
Tom van der Valk
Genomic approaches have the potential to play a pivotal role in conservation, both to detect threats to species and populations and to restore biodiversity through actions. We here separate these approaches into two subdisciplines, vulnerab...
Doogab Yi,Janet E Mertz
Doogab Yi
In fall 1972, Paul Berg's laboratory published articles in PNAS describing two methods for constructing recombinant DNAs in vitro. He received half of the 1980 Nobel Prize in Chemistry for this landmark accomplishment. Here, we describe how...
Cell Editorial Team
Cell Editorial Team
Londa Schiebinger [0.03%]
隆达·谢宾格
Londa Schiebinger
Londa Schiebinger
Dr. Londa Schiebinger is an international leader on the intersection of sex, gender, and science. In this interview with Cell, she discusses the Gendered Innovations project, the persistent STEM gender gap, the importance of considering sex...
Direct interrogation of context-dependent GPCR activity with a universal biosensor platform [0.03%]
通用型生物传感器平台对依赖上下文的GPCR活性进行直接检测
Remi Janicot,Marcin Maziarz,Jong-Chan Park et al.
Remi Janicot et al.
G protein-coupled receptors (GPCRs) are the largest family of druggable proteins encoded in the human genome, but progress in understanding and targeting them is hindered by the lack of tools to reliably measure their nuanced behavior in ph...
CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut [0.03%]
CRB1相关性视网膜变性依赖于细菌从肠道转移
Shanzhen Peng,Jing Jing Li,Wanying Song et al.
Shanzhen Peng et al.
The Crumbs homolog 1 (CRB1) gene is associated with retinal degeneration, most commonly Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). Here, we demonstrate that murine retinas bearing the Rd8 mutation of Crb1 are characteri...
Caroline I Jahn,Nikola T Markov,Britney Morea et al.
Caroline I Jahn et al.
Attention filters sensory inputs to enhance task-relevant information. It is guided by an "attentional template" that represents the stimulus features that are currently relevant. To understand how the brain learns and uses templates, we tr...
A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells [0.03%]
用于原代人T细胞转录组调控和代谢工程的多功能CRISPR-Cas13d平台
Victor Tieu,Elena Sotillo,Jeremy R Bjelajac et al.
Victor Tieu et al.
CRISPR technologies have begun to revolutionize T cell therapies; however, conventional CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To address these challenges, we developed multiplexed effector guide ...
Mouse oocytes sequester aggregated proteins in degradative super-organelles [0.03%]
小鼠卵母细胞将聚集的蛋白质隔离在降解性超级细胞器中
Gabriele Zaffagnini,Shiya Cheng,Marion C Salzer et al.
Gabriele Zaffagnini et al.
Oocytes are among the longest-lived cells in the body and need to preserve their cytoplasm to support proper embryonic development. Protein aggregation is a major threat for intracellular homeostasis in long-lived cells. How oocytes cope wi...
Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation [0.03%]
α7烟碱型受体变构调节和激活的结构机制
Sean M Burke,Mariia Avstrikova,Colleen M Noviello et al.
Sean M Burke et al.
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in cholinergic signaling throughout the nervous system. Its unique physiological characteristics and implications in neurological...