The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression [0.03%]
CARD8炎性体决定HIV/SIV的病原学和疾病进程
Qiankun Wang,Kolin M Clark,Ritudhwaj Tiwari et al.
Qiankun Wang et al.
While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-infected macaques, the mechanisms underlying this depletion remain incompletely understood, with most cell death involving uninfected cells. In cont...
A cryptic plasmid is among the most numerous genetic elements in the human gut [0.03%]
人体肠道中最丰富的基因元素之一是一种神秘的质粒
Emily C Fogarty,Matthew S Schechter,Karen Lolans et al.
Emily C Fogarty et al.
Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing features. However, many bacteria carry "cryptic" plasmids that do not confer clear beneficial functions. We identified one such cryptic plasmid, pBI143, whic...
Ángel Vergara-Cruces,Ishika Pramanick,David Pearce et al.
Ángel Vergara-Cruces et al.
Chloroplast genes encoding photosynthesis-associated proteins are predominantly transcribed by the plastid-encoded RNA polymerase (PEP). PEP is a multi-subunit complex composed of plastid-encoded subunits similar to bacterial RNA polymerase...
Xiao-Xian Wu,Wen-Hui Mu,Fan Li et al.
Xiao-Xian Wu et al.
Chloroplasts are green plastids in the cytoplasm of eukaryotic algae and plants responsible for photosynthesis. The plastid-encoded RNA polymerase (PEP) plays an essential role during chloroplast biogenesis from proplastids and functions as...
F Vanessa Loiacono,Ralph Bock
F Vanessa Loiacono
RNA polymerases (RNAPs) control the first step of gene expression in all forms of life by transferring genetic information from DNA to RNA, a process known as transcription. In this issue of Cell, Webster et al. and Wu et al. report three-d...
Jae-Hyun Yang,Motoshi Hayano,Luis A Rajman et al.
Jae-Hyun Yang et al.
James A Timmons,Charles Brenner
James A Timmons
Martin Pacesa,Oana Pelea,Martin Jinek
Martin Pacesa
Genome editing has been a transformative force in the life sciences and human medicine, offering unprecedented opportunities to dissect complex biological processes and treat the underlying causes of many genetic diseases. CRISPR-based tech...
Tuuli Lappalainen,Yang I Li,Sohini Ramachandran et al.
Tuuli Lappalainen et al.
Human genetics has emerged as one of the most dynamic areas of biology, with a broadening societal impact. In this review, we discuss recent achievements, ongoing efforts, and future challenges in the field. Advances in technology, statisti...
E Andrew Bennett,Qiaomei Fu
E Andrew Bennett
Growing evidence from archaic and early modern human genomes brings new insights to the emergence of modern humans. We recount recent information collected from ancient DNA studies that inform us about the evolutionary pathway to modern hum...