Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques [0.03%]
疫苗在猕猴体内诱导产生CD4模仿的HIV-1广谱中和抗体前体
Kevin O Saunders,James Counts,Bhishem Thakur et al.
Kevin O Saunders et al.
The CD4-binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for many reasons, including the occlusion o...
The innovation menagerie: New institutional structures are expanding horizons for early-stage research [0.03%]
创新动物园：新型机构正在拓展早期研究的疆域
Samuel G Rodriques
Samuel G Rodriques
Academia is a vital source of innovation and discovery, but it faces challenges in funding and coordination. These challenges limit the scope and impact of academic research. Now, philanthropists and governments are exploring new institutio...
Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies [0.03%]
小细胞肺癌的蛋白质基因组特征识别出了生物新见解和亚型特异性的治疗策略
Qian Liu,Jing Zhang,Chenchen Guo et al.
Qian Liu et al.
We performed comprehensive proteogenomic characterization of small cell lung cancer (SCLC) using paired tumors and adjacent lung tissues from 112 treatment-naive patients who underwent surgical resection. Integrated multi-omics analysis ill...
Microbial transmission in the social microbiome and host health and disease [0.03%]
社交微生物群中的微生物传播及宿主的健康和疾病
Amar Sarkar,Cameron J A McInroy,Siobhán Harty et al.
Amar Sarkar et al.
Although social interactions are known to drive pathogen transmission, the contributions of socially transmissible host-associated mutualists and commensals to host health and disease remain poorly explored. We use the concept of the social...
A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma [0.03%]
TCF4依赖的基因调控网络赋予黑色素瘤免疫疗法抵抗性
Joanna Pozniak,Dennis Pedri,Ewout Landeloos et al.
Joanna Pozniak et al.
To better understand intrinsic resistance to immune checkpoint blockade (ICB), we established a comprehensive view of the cellular architecture of the treatment-naive melanoma ecosystem and studied its evolution under ICB. Using single-cell...
Haobin Chen,Benjamin J Drapkin,John D Minna
Haobin Chen
Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and phosphoproteomic landscapes of resected SCLC tumors and i...
XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells [0.03%]
XIST直接调节原始人类多能细胞中的X连锁基因和常染色体基因
Iris Dror,Tsotne Chitiashvili,Shawn Y X Tan et al.
Iris Dror et al.
X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of gene expression, wherein the long non-coding RNA XIST spreads across the X chromosome in cis to mediate gene silencing chromosome-wide. In female naive huma...
Cell at fifty [0.03%]
细胞学说五十年
The Cell Editorial Team
The Cell Editorial Team
Fifty years ago, Cell launched with the aspiration of becoming a journal of exciting biology. Today, we begin a year-long celebration of this momentous anniversary. But before we embark on our journey, we first reflect on Cell at fifty and ...
Editorial
Cell. 2024 Jan 4;187(1):1-2. DOI:10.1016/j.cell.2023.12.009 2024
Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus [0.03%]
东方马脑炎病毒利用VLDLR的结构和功能基础
Lucas J Adams,Saravanan Raju,Hongming Ma et al.
Lucas J Adams et al.
The very-low-density lipoprotein receptor (VLDLR) comprises eight LDLR type A (LA) domains and supports entry of distantly related alphaviruses, including Eastern equine encephalitis virus (EEEV) and Semliki Forest virus (SFV). Here, by res...
Cytoneme signaling provides essential contributions to mammalian tissue patterning [0.03%]
细胞纳米管信号对哺乳动物组织模式形成做出重要贡献
Eric T Hall,Miriam E Dillard,Elizabeth R Cleverdon et al.
Eric T Hall et al.
During development, morphogens pattern tissues by instructing cell fate across long distances. Directly visualizing morphogen transport in situ has been inaccessible, so the molecular mechanisms ensuring successful morphogen delivery remain...