Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle [0.03%]
真核细胞周期中蛋白质组水平的移动及各部分间的连通性
Athanasios Litsios,Benjamin T Grys,Oren Z Kraus et al.
Athanasios Litsios et al.
Cell cycle progression relies on coordinated changes in the composition and subcellular localization of the proteome. By applying two distinct convolutional neural networks on images of millions of live yeast cells, we resolved proteome-lev...
Yingcheng Wu,Jiaqiang Ma,Xupeng Yang et al.
Yingcheng Wu et al.
Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing functions across cancer types. However, given their short half-life, it remains challenging to explore how neutrophils adopt specific fates in cancer. ...
A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes [0.03%]
小鼠DRG基因工具包揭示了躯体感觉神经元亚型的形态和生理多样性
Lijun Qi,Michael Iskols,David Shi et al.
Lijun Qi et al.
Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron subtypes relay neural signals from the periphery to the CNS has been ...
Underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic [0.03%]
未被发现的传播和广泛的本地传播推动了2022年猴痘疫情
Miguel I Paredes,Nashwa Ahmed,Marlin Figgins et al.
Miguel I Paredes et al.
The World Health Organization declared mpox a public health emergency of international concern in July 2022. To investigate global mpox transmission and population-level changes associated with controlling spread, we built phylogeographic a...
Structurally divergent and recurrently mutated regions of primate genomes [0.03%]
灵长类基因组中结构不同且反复突变的区域
Yafei Mao,William T Harvey,David Porubsky et al.
Yafei Mao et al.
We sequenced and assembled using multiple long-read sequencing technologies the genomes of chimpanzee, bonobo, gorilla, orangutan, gibbon, macaque, owl monkey, and marmoset. We identified 1,338,997 lineage-specific fixed structural variants...
Wei-Wei Wang,Su-Yu Ji,Wenjia Zhang et al.
Wei-Wei Wang et al.
Apelin is a key hormone in cardiovascular homeostasis that activates the apelin receptor (APLNR), which is regarded as a promising therapeutic target for cardiovascular disease. However, adverse effects through the β-arrestin pathway limit...
Amélie Collins,James W Swann,Melissa A Proven et al.
Amélie Collins et al.
Neonates are highly susceptible to inflammation and infection. Here, we investigate how late fetal liver (FL) mouse hematopoietic stem and progenitor cells (HSPCs) respond to inflammation, testing the hypothesis that deficits in the engagem...
Ed Hurt,Janet Iwasa,Roland Beckmann
Ed Hurt
Ribosome production is essential for cell growth. Approximately 200 assembly factors drive this complicated pathway that starts in the nucleolus and ends in the cytoplasm. A large number of structural snapshots of the pre-60S pathway have r...
Jae-Hyun Yang,Motoshi Hayano,Patrick T Griffin et al.
Jae-Hyun Yang et al.
Published Erratum
Cell. 2024 Feb 29;187(5):1312-1313. DOI:10.1016/j.cell.2024.01.049 2024
Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries [0.03%]
通过移植和立体排除法快速模拟糖蛋白结构
Yu-Xi Tsai,Ning-En Chang,Klaus Reuter et al.
Yu-Xi Tsai et al.
Most membrane proteins are modified by covalent addition of complex sugars through N- and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary structures and remain very mobile, shielding potentially large fra...