Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells [0.03%]
癌细胞源性Tau通过SLC6A6介导的CD8+t细胞 Tau摄取促进免疫检查点基因表达及T细胞衰竭诱导作用
Tianyu Cao,Wenyao Zhang,Qi Wang et al.
Tianyu Cao et al.
Taurine is used to bolster immunity, but its effects on antitumor immunity are unclear. Here, we report that cancer-related taurine consumption causes T cell exhaustion and tumor progression. The taurine transporter SLC6A6 is correlated wit...
Barcoding of episodic memories in the hippocampus of a food-caching bird [0.03%]
食储鸟海马脑中关于时序记忆的条形码机制神经系统实验研究
Selmaan N Chettih,Emily L Mackevicius,Stephanie Hale et al.
Selmaan N Chettih et al.
The hippocampus is critical for episodic memory. Although hippocampal activity represents place and other behaviorally relevant variables, it is unclear how it encodes numerous memories of specific events in life. To study episodic coding, ...
The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity [0.03%]
SPATA5-SPATA5L1解旋酶复合体调控复制叉蛋白稳态以维持基因组稳定性
Vidhya Krishnamoorthy,Martina Foglizzo,Robert L Dilley et al.
Vidhya Krishnamoorthy et al.
Ubiquitin-dependent unfolding of the CMG helicase by VCP/p97 is required to terminate DNA replication. Other replisome components are not processed in the same fashion, suggesting that additional mechanisms underlie replication protein turn...
Flexible scaffold-based cheminformatics approach for polypharmacological drug design [0.03%]
基于灵活支架的化学信息学方法在多药理药物设计中的应用
Zhangcheng Chen,Jing Yu,Huan Wang et al.
Zhangcheng Chen et al.
Effective treatments for complex central nervous system (CNS) disorders require drugs with polypharmacology and multifunctionality, yet designing such drugs remains a challenge. Here, we present a flexible scaffold-based cheminformatics app...
Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices [0.03%]
甲壳膜蛋白结构揭示了原生羟脯氨酸丰富螺旋O-聚糖的编码规则
Jin Dai,Meisheng Ma,Qingwei Niu et al.
Jin Dai et al.
Hydroxyproline-rich glycoproteins (HRGPs) are a ubiquitous class of protein in the extracellular matrices and cell walls of plants and algae, yet little is known of their native structures or interactions. Here, we used electron cryomicrosc...
Hua Qiu,Xiandeng Wu,Xiaoli Ma et al.
Hua Qiu et al.
In addition to long-distance molecular motor-mediated transport, cellular vesicles also need to be moved at short distances with defined directions to meet functional needs in subcellular compartments but with unknown mechanisms. Such short...
Eduard M Unterauer,Sayedali Shetab Boushehri,Kristina Jevdokimenko et al.
Eduard M Unterauer et al.
To understand biological processes, it is necessary to reveal the molecular heterogeneity of cells by gaining access to the location and interaction of all biomolecules. Significant advances were achieved by super-resolution microscopy, but...
Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging [0.03%]
利用瞬时适配器进行高通量多重超分辨率成像以解析细胞复杂性
Florian Schueder,Felix Rivera-Molina,Maohan Su et al.
Florian Schueder et al.
Mapping the intricate spatial relationships between the many different molecules inside a cell is essential to understanding cellular functions in all their complexity. Super-resolution fluorescence microscopy offers the required spatial re...
Structure-guided discovery of protein and glycan components in native mastigonemes [0.03%]
结构导向的发现天然鞭毛饰物中的蛋白质和糖链成分
Junhao Huang (黄隽豪),Hui Tao (陶慧),Jikun Chen (陈继坤) et al.
Junhao Huang (黄隽豪) et al.
Mastigonemes, the hair-like lateral appendages lining cilia or flagella, participate in mechanosensation and cellular motion, but their constituents and structure have remained unclear. Here, we report the cryo-EM structure of native mastig...
K Verkerk,E E Voest
K Verkerk
The precision oncology paradigm challenges the feasibility and data generalizability of traditional clinical trials. Consequently, an unmet need exists for practical approaches to test many subgroups, evaluate real-world drug value, and gat...