Bispecific dendritic-T cell engager potentiates anti-tumor immunity [0.03%]
双特异性树突细胞-T细胞衔接器增强抗肿瘤免疫反应
Yuval Shapir Itai,Oren Barboy,Ran Salomon et al.
Yuval Shapir Itai et al.
Immune checkpoint inhibition treatment using aPD-1 monoclonal antibodies is a promising cancer immunotherapy approach. However, its effect on tumor immunity is narrow, as most patients do not respond to the treatment or suffer from recurren...
David A Mackey,Sandra E Staffieri
David A Mackey
Although the blinding eye disease glaucoma is more common in people of African ancestry, previous genetic studies predominantly involved European subjects. In this issue of Cell, O'Brien et al. report a genome-wide association study for gla...
Salma Baig,Frank Winkler
Salma Baig
Tumors are not simply a chaotic mass of mutated cells but can follow complex organizational principles, including in space. In this issue of Cell, Mathur and colleagues reconstruct a 3D genomic, epigenomic, and transcriptomic spatial cartog...
Making the connection: How membrane contact sites have changed our view of organelle biology [0.03%]
建立联系：膜接触位点是如何改变我们对细胞器生物学的见解的
G K Voeltz,E M Sawyer,G Hajnóczky et al.
G K Voeltz et al.
The view of organelles and how they operate together has changed dramatically over the last two decades. The textbook view of organelles was that they operated largely independently and were connected by vesicular trafficking and the diffus...
Cell death [0.03%]
细胞死亡
Kim Newton,Andreas Strasser,Nobuhiko Kayagaki et al.
Kim Newton et al.
Cell death supports morphogenesis during development and homeostasis after birth by removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating infected cells. Cell death can be induced by the genetically pro...
Through the looking glass: An adventure into the metastable world of the bacterial cytoplasm [0.03%]
透过玻璃镜：探索细菌细胞质的亚稳定世界
Christine Jacobs-Wagner
Christine Jacobs-Wagner
This personal story recounts the accidental observation, the struggles, the breakthroughs, and the collaborative spirit of a few individuals that led to the discovery that bacterial cells expend energy to effectively fluidize their otherwis...
Cell Reports Editor Shawnna Buttery interviewed Holly Goodson, Wallace Marshall, and Thibaut Brunet at the annual ASCB/EMBO Cell Bio conference. Shawnna asked how non-traditional organisms help us better understand the fundamentals of cell ...
Cell biology is… [0.03%]
细胞生物学是……
Julie A Theriot,Anne Simonsen,Iva Tolić et al.
Julie A Theriot et al.
50 years ago, cell biology was a nascent field. Today, it is a vast discipline whose principles and tools are also applied to other disciplines; vice versa, cell biologists are inspired by other fields. So, the question begs: what is cell b...
Cell Editorial Team
Cell Editorial Team
Cell's 50th anniversary celebrations begin with our special focus issue on cell biology. Foundational and critical to our understanding of life and mechanisms of disease, explore Leading Edge content covering exciting frontiers of this fiel...
Inherited blood cancer predisposition through altered transcription elongation [0.03%]
通过转录延长改变而遗传的血液癌症易感性
Jiawei Zhao,Liam D Cato,Uma P Arora et al.
Jiawei Zhao et al.
Despite advances in defining diverse somatic mutations that cause myeloid malignancies, a significant heritable component for these cancers remains largely unexplained. Here, we perform rare variant association studies in a large population...