For Cell's 50th anniversary Focus on Immunology, scientific editor Cheri Sirois asked science communicator Liz Neeley, founding partner of Liminal and cofounder of Solving for Science, to discuss strategies for tackling technical complexity...
Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties [0.03%]
全局位点解析泛素化占有率和周转率的分析揭示了系统属性
Gabriela Prus,Shankha Satpathy,Brian T Weinert et al.
Gabriela Prus et al.
Ubiquitylation regulates most proteins and biological processes in a eukaryotic cell. However, the site-specific occupancy (stoichiometry) and turnover rate of ubiquitylation have not been quantified. Here we present an integrated picture o...
NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks [0.03%]
NINJ1通过切割并释放膜盘介导质膜破裂
Liron David,Jazlyn P Borges,L Robert Hollingsworth et al.
Liron David et al.
The membrane protein NINJ1 mediates plasma membrane rupture in pyroptosis and other lytic cell death pathways. Here, we report the cryo-EM structure of a NINJ1 oligomer segmented from NINJ1 rings. Each NINJ1 subunit comprises amphipathic (...
RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells [0.03%]
在宿主细胞中可视化蓝舌病毒的RNA基因组包装和衣壳装配过程
Xian Xia,Po-Yu Sung,Michael W Martynowycz et al.
Xian Xia et al.
Unlike those of double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), and ssRNA viruses, the mechanism of genome packaging of dsRNA viruses is poorly understood. Here, we combined the techniques of high-resolution cryoelectron microscop...
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion [0.03%]
ITPRIPL1通过结合CD3ε抑制T细胞活化并促进肿瘤免疫逃逸
Shouyan Deng,Yibo Zhang,Huanbin Wang et al.
Shouyan Deng et al.
Cancer immunotherapy has transformed treatment possibilities, but its effectiveness differs significantly among patients, indicating the presence of alternative pathways for immune evasion. Here, we show that ITPRIPL1 functions as an inhibi...
Direct observation of a condensate effect on super-enhancer controlled gene bursting [0.03%]
超增强子调控基因爆发现象的冷凝物效应的直接观察
Manyu Du,Simon Hendrik Stitzinger,Jan-Hendrik Spille et al.
Manyu Du et al.
Published Erratum
Cell. 2024 May 9;187(10):2595-2598. DOI:10.1016/j.cell.2024.04.001 2024
Chromatin context-dependent regulation and epigenetic manipulation of prime editing [0.03%]
染色质环境依赖性调控和表观遗传修饰引导的prime编辑技术及其应用
Xiaoyi Li,Wei Chen,Beth K Martin et al.
Xiaoyi Li et al.
We set out to exhaustively characterize the impact of the cis-chromatin environment on prime editing, a precise genome engineering tool. Using a highly sensitive method for mapping the genomic locations of randomly integrated reporters, we ...
A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2 [0.03%]
一种糖酵解代谢物绕过BRCA2“两次打击”肿瘤抑制作用
Li Ren Kong,Komal Gupta,Andy Jialun Wu et al.
Li Ren Kong et al.
Knudson's "two-hit" paradigm posits that carcinogenesis requires inactivation of both copies of an autosomal tumor suppressor gene. Here, we report that the glycolytic metabolite methylglyoxal (MGO) transiently bypasses Knudson's paradigm b...
Michael A Fischbach
Michael A Fischbach
Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for evaluating impact and likelihood of success...
W Marcus Lambert,Marlene Camacho-Rivera,Carla Boutin-Foster et al.
W Marcus Lambert et al.
"Helicopter research" refers to a practice where researchers from wealthier countries conduct studies in lower-income countries with little involvement of local researchers or community members. This practice also occurs domestically. In th...