Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes [0.03%]
人神经元和少突胶质细胞体细胞突变模式的差异性分析
Javier Ganz,Lovelace J Luquette,Sara Bizzotto et al.
Javier Ganz et al.
Characterizing somatic mutations in the brain is important for disentangling the complex mechanisms of aging, yet little is known about mutational patterns in different brain cell types. Here, we performed whole-genome sequencing (WGS) of 8...
Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient [0.03%]
大分子凝聚调控核仁亚相以建立pH梯度
Matthew R King,Kiersten M Ruff,Andrew Z Lin et al.
Matthew R King et al.
Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks interspersed by E-rich regions, as defining features of nuc...
Xiaoli Hu,Fengyi Chen,Liangjie Jia et al.
Xiaoli Hu et al.
The reciprocal coordination between cholesterol absorption in the intestine and de novo cholesterol synthesis in the liver is essential for maintaining cholesterol homeostasis, yet the mechanisms governing the opposing regulation of these p...
Type-I-interferon-responsive microglia shape cortical development and behavior [0.03%]
I型干扰素反应的小胶质细胞影响皮层发育和行为
Caroline C Escoubas,Leah C Dorman,Phi T Nguyen et al.
Caroline C Escoubas et al.
Microglia are brain-resident macrophages that shape neural circuit development and are implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have been defined, but their functional significance is unclear. He...
Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer [0.03%]
微生物代谢物通过调节泛癌的T细胞干性来增强免疫治疗效果
Dingjiacheng Jia,Qiwen Wang,Yadong Qi et al.
Dingjiacheng Jia et al.
The immune checkpoint blockade (ICB) response in human cancers is closely linked to the gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is positively correlated with the responsiveness of ICB. Supplem...
First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure [0.03%]
首个MKK4抑制剂促进肝脏再生并预防肝功能衰竭
Stefan Zwirner,Anan A Abu Rmilah,Sabrina Klotz et al.
Stefan Zwirner et al.
Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocy...
Clinical Trial
Cell. 2024 Mar 28;187(7):1666-1684.e26. DOI:10.1016/j.cell.2024.02.023 2024
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic [0.03%]
穿透大脑的前颗粒蛋白生物制剂挽救了由Grn功能丧失引起的溶酶体贮积病
Todd Logan,Matthew J Simon,Anil Rana et al.
Todd Logan et al.
Published Erratum
Cell. 2024 Mar 14;187(6):1565-1566. DOI:10.1016/j.cell.2024.02.015 2024
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling [0.03%]
G蛋白偶联受体信号对Hippo-YAP通路的调控
Fa-Xing Yu,Bin Zhao,Nattapon Panupinthu et al.
Fa-Xing Yu et al.
Published Erratum
Cell. 2024 Mar 14;187(6):1563-1564. DOI:10.1016/j.cell.2024.02.007 2024
ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat [0.03%]
ZP2裂解通过调节卵壳的结构来阻止多精受精
Shunsuke Nishio,Chihiro Emori,Benjamin Wiseman et al.
Shunsuke Nishio et al.
Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP) hardens and polyspermy is irreversibly blocked. These events are associated with the cleavage of the N-terminal region (NTR) of glycoprotein ZP2, a...
mRNA-based monkeypox virus vaccine prevents disease in non-human primates [0.03%]
基于mRNA的猴痘病毒疫苗可预防非人灵长类动物患病
Adam N Nitido,Alejandro B Balazs
Adam N Nitido
The mpox outbreak in 2022 launched a vaccination campaign employing an existing vaccine with moderate protection, highlighting the lack of scalable Orthopoxvirus vaccines with optimal protection. In this issue of Cell, Zuiani et al. report ...