Gut complement induced by the microbiota combats pathogens and spares commensals [0.03%]
微生物群诱导的肠道补体抗病原菌而饶过共生菌
Meng Wu,Wen Zheng,Xinyang Song et al.
Meng Wu et al.
Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a functioning complement system on intestinal mucosal surfaces. Herein, we report the local ...
Ningning Zhang,Wenwen Tang,Lidiane Torres et al.
Ningning Zhang et al.
RNAs localizing to the outer cell surface have been recently identified in mammalian cells, including RNAs with glycan modifications known as glycoRNAs. However, the functional significance of cell surface RNAs and their production are poor...
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme [0.03%]
DNA指导的转录因子协同作用塑造面部和肢体间充质结构
Seungsoo Kim,Ekaterina Morgunova,Sahin Naqvi et al.
Seungsoo Kim et al.
Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF cooperativity. Although in vitro studies suggest tha...
Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity [0.03%]
DGK5介导的PA爆发的双重磷酸化调节植物免疫中的ROS
Liang Kong,Xiyu Ma,Chao Zhang et al.
Liang Kong et al.
Phosphatidic acid (PA) and reactive oxygen species (ROS) are crucial cellular messengers mediating diverse signaling processes in metazoans and plants. How PA homeostasis is tightly regulated and intertwined with ROS signaling upon immune e...
Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling [0.03%]
使用基于PDMS的微流控芯片组件进行冷冻电镜的时间分辨率及其在研究HflX介导的核糖体循环中的应用
Sayan Bhattacharjee,Xiangsong Feng,Suvrajit Maji et al.
Sayan Bhattacharjee et al.
The rapid kinetics of biological processes and associated short-lived conformational changes pose a significant challenge in attempts to structurally visualize biomolecules during a reaction in real time. Conventionally, on-pathway intermed...
Complement in breast milk modifies offspring gut microbiota to promote infant health [0.03%]
母乳中的补体可改变后代的肠道微生物群以促进婴儿健康
Dongqing Xu,Siyu Zhou,Yue Liu et al.
Dongqing Xu et al.
Breastfeeding offers demonstrable benefits to newborns and infants by providing nourishment and immune protection and by shaping the gut commensal microbiota. Although it has been appreciated for decades that breast milk contains complement...
Autism-related dietary preferences mediate autism-gut microbiome associations [0.03%]
与自闭症相关的饮食偏好介导了自闭症-肠道微生物群的关联
Chloe X Yap,Anjali K Henders,Gail A Alvares et al.
Chloe X Yap et al.
Published Erratum
Cell. 2024 Jan 18;187(2):495-510. DOI:10.1016/j.cell.2023.12.001 2024
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma [0.03%]
具有非洲血统的多队列全基因组关联研究揭示了原发性开角型青光眼的风险位点
Shefali S Verma,Harini V Gudiseva,Venkata R M Chavali et al.
Shefali S Verma et al.
Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, disproportionately affects individuals of African ancestry. We conducted a genome-wide association study (GWAS) for POAG in 11,275 individuals of Afr...
Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective [0.03%]
从完整的三维肿瘤视角看胶质母细胞瘤的进化和异质性
Radhika Mathur,Qixuan Wang,Patrick G Schupp et al.
Radhika Mathur et al.
Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection to acquire samples representing the whole tumor mapped...
Coordinating brain-distributed network activities in memory resistant to extinction [0.03%]
记忆中抵抗消退的分布式脑网络活动的协调作用
Charlie J Clarke-Williams,Vítor Lopes-Dos-Santos,Laura Lefèvre et al.
Charlie J Clarke-Williams et al.
Certain memories resist extinction to continue invigorating maladaptive actions. The robustness of these memories could depend on their widely distributed implementation across populations of neurons in multiple brain regions. However, how ...