Challenges and opportunities in oncology drug development and clinical research in China [0.03%]
中国肿瘤药物研发和临床研究的挑战与机遇
Feng Wang,Dan-Yun Ruan,Rui-Hua Xu
Feng Wang
As one of the world's most populous countries, China bears a heavy burden and a broad spectrum of cancers, including unique types, providing a unique environment for drug research and development. In recent years, China has leapt forward in...
Robert A Weinberg
Robert A Weinberg
Discoveries of the roles of RAS oncogenes in cancer development four decades ago opened the door to proving that tumor development is driven by somatic mutations' altering the genomes of cancer cells. These discoveries led to illusions abou...
Moshe Oren,Carol Prives
Moshe Oren
The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet l...
Cell editorial team
Cell editorial team
Over the past 50 years, our understanding of cancer has evolved from its viral origin to a complex systemic disease. Along the way, improved diagnosis and therapeutics saved millions of lives. To mark Cell's 50th anniversary, this focus iss...
Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD [0.03%]
ALS和FTLD中人类运动皮层和前额叶皮层的单细胞分析
S Sebastian Pineda,Hyeseung Lee,Maria J Ulloa-Navas et al.
S Sebastian Pineda et al.
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) share many clinical, pathological, and genetic features, but a detailed understanding of their associated transcriptional alterations across vulnerable cortica...
Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection [0.03%]
肺部感染期间生物膜外多糖改变感觉神经元介导的不适感
Elise Granton,Luke Brown,Manon Defaye et al.
Elise Granton et al.
Infections of the lung cause observable sickness thought to be secondary to inflammation. Signs of sickness are crucial to alert others via behavioral-immune responses to limit contact with contagious individuals. Gram-negative bacteria pro...
Task-driven neural network models predict neural dynamics of proprioception [0.03%]
任务驱动的神经网络模型预测本体感觉神经动力学
Alessandro Marin Vargas,Axel Bisi,Alberto S Chiappa et al.
Alessandro Marin Vargas et al.
Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task-driven modeling approach to investigate the n...
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology [0.03%]
少突胶质细胞在进化中的神经炎症病变和多发性硬化病理中的细胞架构
Petra Kukanja,Christoffer M Langseth,Leslie A Rubio Rodríguez-Kirby et al.
Petra Kukanja et al.
Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and smoldering pathology. Although single-cell analyses provided insights into cytopathology, evolving cellular processes underlying MS remain poorly unde...
Yiqing Wei,Renjie Li,Yufei Meng et al.
Yiqing Wei et al.
The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft. Given its close association with glutamate/glycine co-activated NMDA r...
Yilong Zhou,Amol Panhale,Maria Shvedunova et al.
Yilong Zhou et al.
Biomolecules incur damage during stress conditions, and damage partitioning represents a vital survival strategy for cells. Here, we identified a distinct stress granule (SG), marked by dsRNA helicase DHX9, which compartmentalizes ultraviol...