Chi Chun Wong,Jun Yu
Chi Chun Wong
The landscape of the intratumoral microbiome in tumor metastases is largely unchartered. In this issue of Cell, Voest et al. profiled the tumor metastasis-associated microbiome in a pancancer cohort of 4,160 biopsies from 26 cancer types. T...
Peng Jiang
Peng Jiang
Many types of tumor cells alter metabolic pathways to meet their energy and biosynthetic demands for proliferation or stress adaptation. In this issue of Cell, Kong et al. find that the glycolytic metabolite methylglyoxal causes cancer-asso...
Ana J García-Sáez,Ana I Domingos,J Silvio Gutkind et al.
Ana J García-Sáez et al.
While some people pore over the textbook and train through the classics of the field, many scientists come to immunology when they discover it intersecting with their "first love" interests. Five of these "accidental immunologists" tell us ...
Jonathan D G Jones,Brian J Staskawicz,Jeffery L Dangl
Jonathan D G Jones
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to spec...
Ruslan Medzhitov,Akiko Iwasaki
Ruslan Medzhitov
Several conceptual pillars form the foundation of modern immunology, including the clonal selection theory, antigen receptor diversity, immune memory, and innate control of adaptive immunity. However, some immunological phenomena cannot be ...
Hongbo Chi,Marion Pepper,Paul G Thomas
Hongbo Chi
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we revi...
From periphery to center stage: 50 years of advancements in innate immunity [0.03%]
从中枢到中心舞台：先天免疫50年的研究进展
Susan Carpenter,Luke A J O&#x;Neill
Susan Carpenter
Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely specific activi...
Immunology is for everyone [0.03%]
免疫学与你我相关
Cell editorial team
Cell editorial team
This "Focus on Immunology" issue brings Cell's 50th anniversary celebrations straight to your lymph nodes! Special Leading Edge articles highlight the exciting past, present, and future of the increasingly interdisciplinary field of immunol...
Synthetic protein circuits for programmable control of mammalian cell death [0.03%]
合成蛋白质电路程序控制哺乳动物细胞凋亡
Shiyu Xia,Andrew C Lu,Victoria Tobin et al.
Shiyu Xia et al.
Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate harmful cells and modulate the immune system by dampening or stimulating inflammation. Synthetic protein circuits capable of triggering specific de...
Zhenyu Xiao,Lina Cui,Yang Yuan et al.
Zhenyu Xiao et al.
Progress in understanding early human development has been impeded by the scarcity of reference datasets from natural embryos, particularly those with spatial information during crucial stages like gastrulation. We conducted high-resolution...