Tanja Kortemme
Tanja Kortemme
Methods from artificial intelligence (AI) trained on large datasets of sequences and structures can now "write" proteins with new shapes and molecular functions de novo, without starting from proteins found in nature. In this Perspective, I...
Edward B Miller,Howook Hwang,Mee Shelley et al.
Edward B Miller et al.
High-quality predicted structures enable structure-based approaches to an expanding number of drug discovery programs. We propose that by utilizing free energy perturbation (FEP), predicted structures can be confidently employed to achieve ...
James S Fraser,Mark A Murcko
James S Fraser
Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges: interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling intera...
In November 2023, structural biologists from different countries and different disciplines gathered at the Cell Symposium: Structural biology from the nanoscale to cellular mesoscale to discuss recent breakthroughs, including structures of ...
Cell Editorial Team
Cell Editorial Team
Continuing the celebration of Cell's 50th anniversary, this Focus Issue is an ode to the field of Structural Biology. We present Leading Edge articles highlighting specific approaches and insights that this field offers to answer fundamenta...
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion [0.03%]
SMARCAL1是先天免疫信号和PD-L1表达的双重调节因子，可促进肿瘤免疫逃逸
Giuseppe Leuzzi,Alessandro Vasciaveo,Angelo Taglialatela et al.
Giuseppe Leuzzi et al.
Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection. However, cancer cells often evade these responses by overexpressing immune checkpoint regulators, such as PD-L1. Here, we identify the SN...
PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome [0.03%]
PNMA2形成与副肿瘤性神经综合征相关的免疫原性无包膜病毒样衣壳
Junjie Xu,Simon Erlendsson,Manvendra Singh et al.
Junjie Xu et al.
The paraneoplastic Ma antigen (PNMA) proteins are associated with cancer-induced paraneoplastic syndromes that present with an autoimmune response and neurological symptoms. Why PNMA proteins are associated with this severe autoimmune disea...
Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice [0.03%]
链球菌促进小鼠胃炎症、萎缩和肿瘤的发生
Kaili Fu,Alvin Ho Kwan Cheung,Chi Chun Wong et al.
Kaili Fu et al.
Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with gastric cancer (GC). Here, we show that S. anginosus colonized the mouse stomach and induced acute gastritis. S. anginosus infection spontaneously in...
A 25-year odyssey of genomic technology advances and structural variant discovery [0.03%]
基因组技术进步及结构变异发现25年历程探索
David Porubsky,Evan E Eichler
David Porubsky
This perspective focuses on advances in genome technology over the last 25 years and their impact on germline variant discovery within the field of human genetics. The field has witnessed tremendous technological advances from microarrays t...
Girak Kim,Zuojia Chen,Jian Li et al.
Girak Kim et al.
The gut and liver are recognized to mutually communicate through the biliary tract, portal vein, and systemic circulation. However, it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy and transcri...