Flexible scaffold-based cheminformatics approach for polypharmacological drug design [0.03%]
基于灵活支架的化学信息学方法在多药理药物设计中的应用
Zhangcheng Chen,Jing Yu,Huan Wang et al.
Zhangcheng Chen et al.
Effective treatments for complex central nervous system (CNS) disorders require drugs with polypharmacology and multifunctionality, yet designing such drugs remains a challenge. Here, we present a flexible scaffold-based cheminformatics app...
Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices [0.03%]
甲壳膜蛋白结构揭示了原生羟脯氨酸丰富螺旋O-聚糖的编码规则
Jin Dai,Meisheng Ma,Qingwei Niu et al.
Jin Dai et al.
Hydroxyproline-rich glycoproteins (HRGPs) are a ubiquitous class of protein in the extracellular matrices and cell walls of plants and algae, yet little is known of their native structures or interactions. Here, we used electron cryomicrosc...
Hua Qiu,Xiandeng Wu,Xiaoli Ma et al.
Hua Qiu et al.
In addition to long-distance molecular motor-mediated transport, cellular vesicles also need to be moved at short distances with defined directions to meet functional needs in subcellular compartments but with unknown mechanisms. Such short...
Eduard M Unterauer,Sayedali Shetab Boushehri,Kristina Jevdokimenko et al.
Eduard M Unterauer et al.
To understand biological processes, it is necessary to reveal the molecular heterogeneity of cells by gaining access to the location and interaction of all biomolecules. Significant advances were achieved by super-resolution microscopy, but...
Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging [0.03%]
利用瞬时适配器进行高通量多重超分辨率成像以解析细胞复杂性
Florian Schueder,Felix Rivera-Molina,Maohan Su et al.
Florian Schueder et al.
Mapping the intricate spatial relationships between the many different molecules inside a cell is essential to understanding cellular functions in all their complexity. Super-resolution fluorescence microscopy offers the required spatial re...
Structure-guided discovery of protein and glycan components in native mastigonemes [0.03%]
结构导向的发现天然鞭毛饰物中的蛋白质和糖链成分
Junhao Huang (黄隽豪),Hui Tao (陶慧),Jikun Chen (陈继坤) et al.
Junhao Huang (黄隽豪) et al.
Mastigonemes, the hair-like lateral appendages lining cilia or flagella, participate in mechanosensation and cellular motion, but their constituents and structure have remained unclear. Here, we report the cryo-EM structure of native mastig...
K Verkerk,E E Voest
K Verkerk
The precision oncology paradigm challenges the feasibility and data generalizability of traditional clinical trials. Consequently, an unmet need exists for practical approaches to test many subgroups, evaluate real-world drug value, and gat...
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment [0.03%]
癌症生物标志物：新兴趋势及个性化治疗的临床意义
Antonio Passaro,Maise Al Bakir,Emily G Hamilton et al.
Antonio Passaro et al.
The integration of cancer biomarkers into oncology has revolutionized cancer treatment, yielding remarkable advancements in cancer therapeutics and the prognosis of cancer patients. The development of personalized medicine represents a turn...
Charles Swanton,Elsa Bernard,Chris Abbosh et al.
Charles Swanton et al.
The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifest...
Lia Gore,Maureen M O&#x;Brien
Lia Gore
Dramatic progress in treating childhood cancer has evolved over decades from initial empirically derived treatments to clinical investigations incorporating disease biology with rationally designed therapeutic programs. While cure is now po...