Direct interrogation of context-dependent GPCR activity with a universal biosensor platform [0.03%]
通用型生物传感器平台对依赖上下文的GPCR活性进行直接检测
Remi Janicot,Marcin Maziarz,Jong-Chan Park et al.
Remi Janicot et al.
G protein-coupled receptors (GPCRs) are the largest family of druggable proteins encoded in the human genome, but progress in understanding and targeting them is hindered by the lack of tools to reliably measure their nuanced behavior in ph...
CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut [0.03%]
CRB1相关性视网膜变性依赖于细菌从肠道转移
Shanzhen Peng,Jing Jing Li,Wanying Song et al.
Shanzhen Peng et al.
The Crumbs homolog 1 (CRB1) gene is associated with retinal degeneration, most commonly Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). Here, we demonstrate that murine retinas bearing the Rd8 mutation of Crb1 are characteri...
Caroline I Jahn,Nikola T Markov,Britney Morea et al.
Caroline I Jahn et al.
Attention filters sensory inputs to enhance task-relevant information. It is guided by an "attentional template" that represents the stimulus features that are currently relevant. To understand how the brain learns and uses templates, we tr...
A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells [0.03%]
用于原代人T细胞转录组调控和代谢工程的多功能CRISPR-Cas13d平台
Victor Tieu,Elena Sotillo,Jeremy R Bjelajac et al.
Victor Tieu et al.
CRISPR technologies have begun to revolutionize T cell therapies; however, conventional CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To address these challenges, we developed multiplexed effector guide ...
Mouse oocytes sequester aggregated proteins in degradative super-organelles [0.03%]
小鼠卵母细胞将聚集的蛋白质隔离在降解性超级细胞器中
Gabriele Zaffagnini,Shiya Cheng,Marion C Salzer et al.
Gabriele Zaffagnini et al.
Oocytes are among the longest-lived cells in the body and need to preserve their cytoplasm to support proper embryonic development. Protein aggregation is a major threat for intracellular homeostasis in long-lived cells. How oocytes cope wi...
Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation [0.03%]
α7烟碱型受体变构调节和激活的结构机制
Sean M Burke,Mariia Avstrikova,Colleen M Noviello et al.
Sean M Burke et al.
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in cholinergic signaling throughout the nervous system. Its unique physiological characteristics and implications in neurological...
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a [0.03%]
在使用panobinostat和干扰素-α2a治疗过程中HIV-1前病毒的选择性表观遗传特权现象
Marie Armani-Tourret,Ce Gao,Ciputra Adijaya Hartana et al.
Marie Armani-Tourret et al.
CD4+ T cells with latent HIV-1 infection persist despite treatment with antiretroviral agents and represent the main barrier to a cure of HIV-1 infection. Pharmacological disruption of viral latency may expose HIV-1-infected cells to host i...
Randomized Controlled Trial
Cell. 2024 Feb 29;187(5):1238-1254.e14. DOI:10.1016/j.cell.2024.01.037 2024
The genetic changes that shaped Neandertals, Denisovans, and modern humans [0.03%]
塑造尼安德特人、丹尼索瓦人和现代人类的遗传变化
Hugo Zeberg,Mattias Jakobsson,Svante Pääbo
Hugo Zeberg
Modern human ancestors diverged from the ancestors of Neandertals and Denisovans about 600,000 years ago. Until about 40,000 years ago, these three groups existed in parallel, occasionally met, and exchanged genes. A critical question is wh...
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis [0.03%]
具有两个多不饱和脂肪酰尾的磷脂促进铁死亡
Baiyu Qiu,Fereshteh Zandkarimi,Carla T Bezjian et al.
Baiyu Qiu et al.
Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA1s) are considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA tails (PL-PUFA2s) have been rarely characterized. Dietary lipids modul...
High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota [0.03%]
高脂肪摄入在肠道微生物群的梭状芽胞杆菌经抗生素处理减少后维持了山梨醇不耐受持续存在
Jee-Yon Lee,Connor R Tiffany,Scott P Mahan et al.
Jee-Yon Lee et al.
Carbohydrate intolerance, commonly linked to the consumption of lactose, fructose, or sorbitol, affects up to 30% of the population in high-income countries. Although sorbitol intolerance is attributed to malabsorption, the underlying mecha...