BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis [0.03%]
褐色脂肪中的 BCAA 氮通量调控代谢健康（与产生热量无关）
Anthony R P Verkerke,Dandan Wang,Naofumi Yoshida et al.
Anthony R P Verkerke et al.
Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis is tightly associated with increased energy expenditure, reduced body weight, and improved glucose homeostasis. However,...
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway [0.03%]
肠道共生菌通过次级胆汁酸生物合成途径缓解MASH现象
Qixing Nie,Xi Luo,Kai Wang et al.
Qixing Nie et al.
The gut microbiota has been found to play an important role in the progression of metabolic dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been established. Here, by developing a click-chemistry-based enrichment ...
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis [0.03%]
天冬氨酰-tRNA合成酶AARS1是一种乳酸感受器和p53乳酰化酶，可促进肿瘤发生
Zhi Zong,Feng Xie,Shuai Wang et al.
Zhi Zong et al.
Lysine lactylation is a post-translational modification that links cellular metabolism to protein function. Here, we find that AARS1 functions as a lactate sensor that mediates global lysine lacylation in tumor cells. AARS1 binds to lactate...
Mariko Takahashi,Harrison B Chong,Siwen Zhang et al.
Mariko Takahashi et al.
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To...
Integrative spatial analysis reveals a multi-layered organization of glioblastoma [0.03%]
整合型空间分析揭示了胶质母细胞瘤的多层次组织结构
Alissa C Greenwald,Noam Galili Darnell,Rouven Hoefflin et al.
Alissa C Greenwald et al.
Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, spatial proteomics, and computational approaches to define glioma cellular states and uncover their organization. We find three prominent modes of ...
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses [0.03%]
sarbecovirus逃避NKG2D介导的细胞毒免疫作用
Jordan A Hartmann,Marcella R Cardoso,Maria Cecilia Ramiro Talarico et al.
Jordan A Hartmann et al.
SARS-CoV-2 and other sarbecoviruses continue to threaten humanity, highlighting the need to characterize common mechanisms of viral immune evasion for pandemic preparedness. Cytotoxic lymphocytes are vital for antiviral immunity and express...
Dual-role transcription factors stabilize intermediate expression levels [0.03%]
行使双重职能的转录因子可稳定中间表达水平
Jinnan He,Xiangru Huo,Gaofeng Pei et al.
Jinnan He et al.
Precise control of gene expression levels is essential for normal cell functions, yet how they are defined and tightly maintained, particularly at intermediate levels, remains elusive. Here, using a series of newly developed sequencing, ima...
For Cell's 50th anniversary Focus on Immunology, scientific editor Cheri Sirois asked science communicator Liz Neeley, founding partner of Liminal and cofounder of Solving for Science, to discuss strategies for tackling technical complexity...
Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties [0.03%]
全局位点解析泛素化占有率和周转率的分析揭示了系统属性
Gabriela Prus,Shankha Satpathy,Brian T Weinert et al.
Gabriela Prus et al.
Ubiquitylation regulates most proteins and biological processes in a eukaryotic cell. However, the site-specific occupancy (stoichiometry) and turnover rate of ubiquitylation have not been quantified. Here we present an integrated picture o...
NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks [0.03%]
NINJ1通过切割并释放膜盘介导质膜破裂
Liron David,Jazlyn P Borges,L Robert Hollingsworth et al.
Liron David et al.
The membrane protein NINJ1 mediates plasma membrane rupture in pyroptosis and other lytic cell death pathways. Here, we report the cryo-EM structure of a NINJ1 oligomer segmented from NINJ1 rings. Each NINJ1 subunit comprises amphipathic (...