Jonathan D G Jones,Brian J Staskawicz,Jeffery L Dangl
Jonathan D G Jones
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to spec...
Ruslan Medzhitov,Akiko Iwasaki
Ruslan Medzhitov
Several conceptual pillars form the foundation of modern immunology, including the clonal selection theory, antigen receptor diversity, immune memory, and innate control of adaptive immunity. However, some immunological phenomena cannot be ...
Hongbo Chi,Marion Pepper,Paul G Thomas
Hongbo Chi
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we revi...
From periphery to center stage: 50 years of advancements in innate immunity [0.03%]
从中枢到中心舞台：先天免疫50年的研究进展
Susan Carpenter,Luke A J O&#x;Neill
Susan Carpenter
Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely specific activi...
Immunology is for everyone [0.03%]
免疫学与你我相关
Cell editorial team
Cell editorial team
This "Focus on Immunology" issue brings Cell's 50th anniversary celebrations straight to your lymph nodes! Special Leading Edge articles highlight the exciting past, present, and future of the increasingly interdisciplinary field of immunol...
Synthetic protein circuits for programmable control of mammalian cell death [0.03%]
合成蛋白质电路程序控制哺乳动物细胞凋亡
Shiyu Xia,Andrew C Lu,Victoria Tobin et al.
Shiyu Xia et al.
Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate harmful cells and modulate the immune system by dampening or stimulating inflammation. Synthetic protein circuits capable of triggering specific de...
Zhenyu Xiao,Lina Cui,Yang Yuan et al.
Zhenyu Xiao et al.
Progress in understanding early human development has been impeded by the scarcity of reference datasets from natural embryos, particularly those with spatial information during crucial stages like gastrulation. We conducted high-resolution...
IGSF8 is an innate immune checkpoint and cancer immunotherapy target [0.03%]
IGSF8是一个先天免疫检查点和癌症免疫治疗靶标
Yulong Li,Xiangyang Wu,Caibin Sheng et al.
Yulong Li et al.
Antigen presentation defects in tumors are prevalent mechanisms of adaptive immune evasion and resistance to cancer immunotherapy, whereas how tumors evade innate immunity is less clear. Using CRISPR screens, we discovered that IGSF8 expres...
Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program [0.03%]
表观转录组学程序区分造血干细胞龛的生成和维持
Longfei Gao,Heather Lee,Joshua H Goodman et al.
Longfei Gao et al.
The niche is typically considered as a pre-established structure sustaining stem cells. Therefore, the regulation of its formation remains largely unexplored. Whether distinct molecular mechanisms control the establishment versus maintenanc...
Continuous germinal center invasion contributes to the diversity of the immune response [0.03%]
连续的生发中心侵染促进了免疫反应的多样性
Thomas Hägglöf,Melissa Cipolla,Maximilian Loewe et al.
Thomas Hägglöf et al.
Published Erratum
Cell. 2024 May 23;187(11):2893. DOI:10.1016/j.cell.2024.04.004 2024