Alessia Perino,Hadrien Demagny,Kristina Schoonjans
Alessia Perino
In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism d...
The SkillsCenter: Creating scalable research opportunities for STEM students [0.03%]
SkillsCenter：为STEM学生创建可扩展的研究机会
Zachary Hazlett,Beiyi Xu,Jennifer K Knight et al.
Zachary Hazlett et al.
Undergraduate students generally need laboratory skills and experience to be accepted into a position within an academic lab or a company. However, those settings are traditionally where students would develop that necessary expertise. We d...
Peter W Reddien
Peter W Reddien
Turnover-constant component production and destruction-is ubiquitous in biology. Turnover occurs across organisms and scales, including for RNAs, proteins, membranes, macromolecular structures, organelles, cells, hair, feathers, nails, antl...
Celeste M Nelson,Bailong Xiao,Sara A Wickström et al.
Celeste M Nelson et al.
Mechanobiology-the field studying how cells produce, sense, and respond to mechanical forces-is pivotal in the analysis of how cells and tissues take shape in development and disease. As we venture into the future of this field, pioneers sh...
Establishing a conceptual framework for holistic cell states and state transitions [0.03%]
建立关于整体细胞状态和状态转换的概念框架
Susanne M Rafelski,Julie A Theriot
Susanne M Rafelski
Cell states were traditionally defined by how they looked, where they were located, and what functions they performed. In this post-genomic era, the field is largely focused on a molecular view of cell state. Moving forward, we anticipate t...
Peter H Seeberger,Yun Ge,Christine M Szymanski et al.
Peter H Seeberger et al.
Glycans, with their variable compositions and highly dynamic conformations, vastly expand the heterogeneity of whatever factor or cell they are attached to. These properties make them crucial contributors to biological function and organism...
Anu Suomalainen,Jodi Nunnari
Anu Suomalainen
Mitochondria reside at the crossroads of catabolic and anabolic metabolism-the essence of life. How their structure and function are dynamically tuned in response to tissue-specific needs for energy, growth repair, and renewal is being incr...
Wentao Yang,Huawei Zhai,Fangming Wu et al.
Wentao Yang et al.
Plants frequently encounter wounding and have evolved an extraordinary regenerative capacity to heal the wounds. However, the wound signal that triggers regenerative responses has not been identified. Here, through characterization of a tom...
Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9 [0.03%]
快速解旋DNA可加速CRISPR-Cas9基因组编辑技术
Amy R Eggers,Kai Chen,Katarzyna M Soczek et al.
Amy R Eggers et al.
Thermostable clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas9) enzymes could improve genome-editing efficiency and delivery due to extended protein lifetimes. However, initial experimentation de...
Patterning and folding of intestinal villi by active mesenchymal dewetting [0.03%]
肠绒毛的图案化及由间充质去湿引发的折叠现象
Tyler R Huycke,Teemu J Häkkinen,Hikaru Miyazaki et al.
Tyler R Huycke et al.
Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable nutrient absorption. However, the molecu...