Structurally divergent and recurrently mutated regions of primate genomes [0.03%]
灵长类基因组中结构不同且反复突变的区域
Yafei Mao,William T Harvey,David Porubsky et al.
Yafei Mao et al.
We sequenced and assembled using multiple long-read sequencing technologies the genomes of chimpanzee, bonobo, gorilla, orangutan, gibbon, macaque, owl monkey, and marmoset. We identified 1,338,997 lineage-specific fixed structural variants...
Wei-Wei Wang,Su-Yu Ji,Wenjia Zhang et al.
Wei-Wei Wang et al.
Apelin is a key hormone in cardiovascular homeostasis that activates the apelin receptor (APLNR), which is regarded as a promising therapeutic target for cardiovascular disease. However, adverse effects through the β-arrestin pathway limit...
Amélie Collins,James W Swann,Melissa A Proven et al.
Amélie Collins et al.
Neonates are highly susceptible to inflammation and infection. Here, we investigate how late fetal liver (FL) mouse hematopoietic stem and progenitor cells (HSPCs) respond to inflammation, testing the hypothesis that deficits in the engagem...
Ed Hurt,Janet Iwasa,Roland Beckmann
Ed Hurt
Ribosome production is essential for cell growth. Approximately 200 assembly factors drive this complicated pathway that starts in the nucleolus and ends in the cytoplasm. A large number of structural snapshots of the pre-60S pathway have r...
Jae-Hyun Yang,Motoshi Hayano,Patrick T Griffin et al.
Jae-Hyun Yang et al.
Published Erratum
Cell. 2024 Feb 29;187(5):1312-1313. DOI:10.1016/j.cell.2024.01.049 2024
Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries [0.03%]
通过移植和立体排除法快速模拟糖蛋白结构
Yu-Xi Tsai,Ning-En Chang,Klaus Reuter et al.
Yu-Xi Tsai et al.
Most membrane proteins are modified by covalent addition of complex sugars through N- and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary structures and remain very mobile, shielding potentially large fra...
The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression [0.03%]
CARD8炎性体决定HIV/SIV的病原学和疾病进程
Qiankun Wang,Kolin M Clark,Ritudhwaj Tiwari et al.
Qiankun Wang et al.
While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-infected macaques, the mechanisms underlying this depletion remain incompletely understood, with most cell death involving uninfected cells. In cont...
A cryptic plasmid is among the most numerous genetic elements in the human gut [0.03%]
人体肠道中最丰富的基因元素之一是一种神秘的质粒
Emily C Fogarty,Matthew S Schechter,Karen Lolans et al.
Emily C Fogarty et al.
Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing features. However, many bacteria carry "cryptic" plasmids that do not confer clear beneficial functions. We identified one such cryptic plasmid, pBI143, whic...
Ángel Vergara-Cruces,Ishika Pramanick,David Pearce et al.
Ángel Vergara-Cruces et al.
Chloroplast genes encoding photosynthesis-associated proteins are predominantly transcribed by the plastid-encoded RNA polymerase (PEP). PEP is a multi-subunit complex composed of plastid-encoded subunits similar to bacterial RNA polymerase...
Xiao-Xian Wu,Wen-Hui Mu,Fan Li et al.
Xiao-Xian Wu et al.
Chloroplasts are green plastids in the cytoplasm of eukaryotic algae and plants responsible for photosynthesis. The plastid-encoded RNA polymerase (PEP) plays an essential role during chloroplast biogenesis from proplastids and functions as...