Discovery of antimicrobial peptides in the global microbiome with machine learning [0.03%]
基于机器学习在地球微生物组中发现抗菌肽
Célio Dias Santos-Júnior,Marcelo D T Torres,Yiqian Duan et al.
Célio Dias Santos-Júnior et al.
Novel antibiotics are urgently needed to combat the antibiotic-resistance crisis. We present a machine-learning-based approach to predict antimicrobial peptides (AMPs) within the global microbiome and leverage a vast dataset of 63,410 metag...
The ribotoxic stress response drives UV-mediated cell death [0.03%]
核转录因子κB活化剂的“ribotoxic”应激反应介导紫外线诱导的细胞死亡
Niladri K Sinha,Connor McKenney,Zhong Y Yeow et al.
Niladri K Sinha et al.
While ultraviolet (UV) radiation damages DNA, eliciting the DNA damage response (DDR), it also damages RNA, triggering transcriptome-wide ribosomal collisions and eliciting a ribotoxic stress response (RSR). However, the relative contributi...
Shiyu Li,Min Yang,Hui Shen et al.
Shiyu Li et al.
The cleavage of zygotes generates totipotent blastomeres. In human 8-cell blastomeres, zygotic genome activation (ZGA) occurs to initiate the ontogenesis program. However, capturing and maintaining totipotency in human cells pose significan...
Heterologous survey of 130 DNA transposons in human cells highlights their functional divergence and expands the genome engineering toolbox [0.03%]
异源调查人类细胞中的130种DNA转座子突显其功能分歧并扩大基因组工程工具箱
Tongtong Zhang,Shengjun Tan,Na Tang et al.
Tongtong Zhang et al.
Experimental studies on DNA transposable elements (TEs) have been limited in scale, leading to a lack of understanding of the factors influencing transposition activity, evolutionary dynamics, and application potential as genome engineering...
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss [0.03%]
DNMT3A突变驱动的克隆性血细胞生成促进炎性骨丢失
Hui Wang,Kimon Divaris,Bohu Pan et al.
Hui Wang et al.
Clonal hematopoiesis of indeterminate potential (CHIP) arises from aging-associated acquired mutations in hematopoietic progenitors, which display clonal expansion and produce phenotypically altered leukocytes. We associated CHIP-DNMT3A mut...
DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells [0.03%]
基于DNA的ForceChrono探针用于解析活细胞中单分子力的动力学特征
Yuru Hu,Hongyun Li,Chen Zhang et al.
Yuru Hu et al.
Understanding cellular force transmission dynamics is crucial in mechanobiology. We developed the DNA-based ForceChrono probe to measure force magnitude, duration, and loading rates at the single-molecule level within living cells. The Forc...
POT1 recruits and regulates CST-Polα/primase at human telomeres [0.03%]
端粒结合蛋白POT1通过招募和调控CST- Polα/引物酶复合体来参与人类端粒维持
Sarah W Cai,Hiroyuki Takai,Arthur J Zaug et al.
Sarah W Cai et al.
Telomere maintenance requires the extension of the G-rich telomeric repeat strand by telomerase and the fill-in synthesis of the C-rich strand by Polα/primase. At telomeres, Polα/primase is bound to Ctc1/Stn1/Ten1 (CST), a single-stranded...
De novo and salvage purine synthesis pathways across tissues and tumors [0.03%]
从头和补救性嘌呤合成途径在组织和肿瘤中的作用
Diem H Tran,Dohun Kim,Rushendhiran Kesavan et al.
Diem H Tran et al.
Purine nucleotides are vital for RNA and DNA synthesis, signaling, metabolism, and energy homeostasis. To synthesize purines, cells use two principal routes: the de novo and salvage pathways. Traditionally, it is believed that proliferating...
A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis [0.03%]
一种假常染色体糖基化障碍促使对多胺生物合成的修订
Matthew P Wilson,Takfarinas Kentache,Charlotte R Althoff et al.
Matthew P Wilson et al.
Dolichol is a lipid critical for N-glycosylation as a carrier for activated sugars and nascent oligosaccharides. It is commonly thought to be directly produced from polyprenol by the enzyme SRD5A3. Instead, we found that dolichol synthesis ...
Taehong Yang,Daniel W Bayless,Yichao Wei et al.
Taehong Yang et al.
Published Erratum
Cell. 2024 Jul 11;187(14):3782. DOI:10.1016/j.cell.2024.05.046 2024