Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer [0.03%]
微生物代谢物通过调节泛癌的T细胞干性来增强免疫治疗效果
Dingjiacheng Jia,Qiwen Wang,Yadong Qi et al.
Dingjiacheng Jia et al.
The immune checkpoint blockade (ICB) response in human cancers is closely linked to the gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is positively correlated with the responsiveness of ICB. Supplem...
First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure [0.03%]
首个MKK4抑制剂促进肝脏再生并预防肝功能衰竭
Stefan Zwirner,Anan A Abu Rmilah,Sabrina Klotz et al.
Stefan Zwirner et al.
Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocy...
Clinical Trial
Cell. 2024 Mar 28;187(7):1666-1684.e26. DOI:10.1016/j.cell.2024.02.023 2024
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic [0.03%]
穿透大脑的前颗粒蛋白生物制剂挽救了由Grn功能丧失引起的溶酶体贮积病
Todd Logan,Matthew J Simon,Anil Rana et al.
Todd Logan et al.
Published Erratum
Cell. 2024 Mar 14;187(6):1565-1566. DOI:10.1016/j.cell.2024.02.015 2024
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling [0.03%]
G蛋白偶联受体信号对Hippo-YAP通路的调控
Fa-Xing Yu,Bin Zhao,Nattapon Panupinthu et al.
Fa-Xing Yu et al.
Published Erratum
Cell. 2024 Mar 14;187(6):1563-1564. DOI:10.1016/j.cell.2024.02.007 2024
ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat [0.03%]
ZP2裂解通过调节卵壳的结构来阻止多精受精
Shunsuke Nishio,Chihiro Emori,Benjamin Wiseman et al.
Shunsuke Nishio et al.
Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP) hardens and polyspermy is irreversibly blocked. These events are associated with the cleavage of the N-terminal region (NTR) of glycoprotein ZP2, a...
mRNA-based monkeypox virus vaccine prevents disease in non-human primates [0.03%]
基于mRNA的猴痘病毒疫苗可预防非人灵长类动物患病
Adam N Nitido,Alejandro B Balazs
Adam N Nitido
The mpox outbreak in 2022 launched a vaccination campaign employing an existing vaccine with moderate protection, highlighting the lack of scalable Orthopoxvirus vaccines with optimal protection. In this issue of Cell, Zuiani et al. report ...
Eric Verdin
Eric Verdin
Brian A Aguado,Daniel L Jeffries,Rebecca Jordan-Young et al.
Brian A Aguado et al.
Our understanding of sex and gender evolves. We asked scientists about their work and the future of sex and gender research. They discuss, among other things, interdisciplinary collaboration, moving beyond binary conceptualizations, account...
Shirin Heidari [0.03%]
希林·海达里
Shirin Heidari
Shirin Heidari
Dr. Shirin Heidari is the lead author of the Sex and Gender Equity in Research (SAGER) guidelines. In this interview with Dr. Isabel Goldman at Cell, she discusses her research, GENDRO, the SAGER guidelines and importance of considering sex...
Beans Velocci
Beans Velocci
The history of sex research demonstrates an ongoing coexistence of multiple, conflicting meanings of sex. This history raises questions for scientists about the deployment of a research variable that lacks precision. Cross-disciplinary coll...