MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels [0.03%]
线粒体融合通过控制内膜质量维持线粒体DNA水平取决于 MTFP1蛋白质
Luis Carlos Tábara,Stephen P Burr,Michele Frison et al.
Luis Carlos Tábara et al.
Mitochondrial dynamics play a critical role in cell fate decisions and in controlling mtDNA levels and distribution. However, the molecular mechanisms linking mitochondrial membrane remodeling and quality control to mtDNA copy number (CN) r...
Erla R Árnadóttir,Kristján H S Moore,Valdís B Guðmundsdóttir et al.
Erla R Árnadóttir et al.
We examined the rate and nature of mitochondrial DNA (mtDNA) mutations in humans using sequence data from 64,806 contemporary Icelanders from 2,548 matrilines. Based on 116,663 mother-child transmissions, 8,199 mutations were detected, prov...
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury [0.03%]
肠损伤后的肠道 isthmus 干细胞对维持稳态和再生的贡献
Ermanno Malagola,Alessandro Vasciaveo,Yosuke Ochiai et al.
Ermanno Malagola et al.
The currently accepted intestinal epithelial cell organization model proposes that Lgr5+ crypt-base columnar (CBC) cells represent the sole intestinal stem cell (ISC) compartment. However, previous studies have indicated that Lgr5+ cells ar...
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells [0.03%]
时间分辨谱系示踪鉴定出肠道上部隐窝区是Lgr5阳性隐窝基底柱状细胞的起源地
Claudia Capdevila,Jonathan Miller,Liang Cheng et al.
Claudia Capdevila et al.
In the prevailing model, Lgr5+ cells are the only intestinal stem cells (ISCs) that sustain homeostatic epithelial regeneration by upward migration of progeny through elusive upper crypt transit-amplifying (TA) intermediates. Here, we ident...
A developmental constraint model of cancer cell states and tumor heterogeneity [0.03%]
发育约束下的癌细胞状态及肿瘤异质性模型
Ayushi S Patel,Itai Yanai
Ayushi S Patel
Cancer is a disease that stems from a fundamental liability inherent to multicellular life forms in which an individual cell is capable of reneging on the interests of the collective organism. Although cancer is commonly described as an evo...
Sergey Kryazhimskiy
Sergey Kryazhimskiy
Microbial communities perform many important functions, such as carbon sequestration, decomposition, pathogen resistance, etc., but quantitatively predicting functions of new communities remains a major challenge. In this issue of Cell, Dia...
Poulami Chatterjee,Laura M K Dassama
Poulami Chatterjee
Gut microbes are known to impact host physiology in several ways. However, key molecular players in host-commensal interactions remain to be uncovered. In this issue of Cell, McCurry et al. reveal that gut bacteria perform 21-dehydroxylatio...
Mei-Lan Li,Kaelyn Sumigray
Mei-Lan Li
In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al.1 and Malagola, Vasciaveo, et al.2 identify a new ISC population in the upper cry...
On mechanical phase and form [0.03%]
论机械的相和形
Windie Höfs,Sara A Wickström
Windie Höfs
Epithelial folding is a fundamental biological process that requires epithelial interactions with the underlying mesenchyme. In this issue of Cell, Huycke et al. investigate intestinal villus formation. They discover that water-droplet-like...
Silvia Sookoian,Carlos Jose Pirola
Silvia Sookoian
Resmetirom is an oral selective THR-β agonist conditionally approved for the treatment of patients with noncirrhotic MASH with moderate to advanced fibrosis. Resmetirom restores mitochondrial and hepatic metabolic function; reduces atherog...