Celeste M Nelson,Bailong Xiao,Sara A Wickström et al.
Celeste M Nelson et al.
Mechanobiology-the field studying how cells produce, sense, and respond to mechanical forces-is pivotal in the analysis of how cells and tissues take shape in development and disease. As we venture into the future of this field, pioneers sh...
Establishing a conceptual framework for holistic cell states and state transitions [0.03%]
建立关于整体细胞状态和状态转换的概念框架
Susanne M Rafelski,Julie A Theriot
Susanne M Rafelski
Cell states were traditionally defined by how they looked, where they were located, and what functions they performed. In this post-genomic era, the field is largely focused on a molecular view of cell state. Moving forward, we anticipate t...
Peter H Seeberger,Yun Ge,Christine M Szymanski et al.
Peter H Seeberger et al.
Glycans, with their variable compositions and highly dynamic conformations, vastly expand the heterogeneity of whatever factor or cell they are attached to. These properties make them crucial contributors to biological function and organism...
Anu Suomalainen,Jodi Nunnari
Anu Suomalainen
Mitochondria reside at the crossroads of catabolic and anabolic metabolism-the essence of life. How their structure and function are dynamically tuned in response to tissue-specific needs for energy, growth repair, and renewal is being incr...
Wentao Yang,Huawei Zhai,Fangming Wu et al.
Wentao Yang et al.
Plants frequently encounter wounding and have evolved an extraordinary regenerative capacity to heal the wounds. However, the wound signal that triggers regenerative responses has not been identified. Here, through characterization of a tom...
Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9 [0.03%]
快速解旋DNA可加速CRISPR-Cas9基因组编辑技术
Amy R Eggers,Kai Chen,Katarzyna M Soczek et al.
Amy R Eggers et al.
Thermostable clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas9) enzymes could improve genome-editing efficiency and delivery due to extended protein lifetimes. However, initial experimentation de...
Patterning and folding of intestinal villi by active mesenchymal dewetting [0.03%]
肠绒毛的图案化及由间充质去湿引发的折叠现象
Tyler R Huycke,Teemu J Häkkinen,Hikaru Miyazaki et al.
Tyler R Huycke et al.
Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable nutrient absorption. However, the molecu...
Juan Diaz-Colunga,Abigail Skwara,Jean C C Vila et al.
Juan Diaz-Colunga et al.
The many functions of microbial communities emerge from a complex web of interactions between organisms and their environment. This poses a significant obstacle to engineering microbial consortia, hindering our ability to harness the potent...
Human inherited CCR2 deficiency underlies progressive polycystic lung disease [0.03%]
人源CCR2缺陷导致进行性肺囊性疾病
Anna-Lena Neehus,Brenna Carey,Marija Landekic et al.
Anna-Lena Neehus et al.
Published Erratum
Cell. 2024 Jun 20;187(13):3460. DOI:10.1016/j.cell.2024.05.021 2024
A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases [0.03%]
一个人类培养肠道真菌基因组汇编表征了与常见疾病相关的肠霉菌群
Qiulong Yan,Shenghui Li,Qingsong Yan et al.
Qiulong Yan et al.
The gut fungal community represents an essential element of human health, yet its functional and metabolic potential remains insufficiently elucidated, largely due to the limited availability of reference genomes. To address this gap, we pr...