STING orchestrates the neuronal inflammatory stress response in multiple sclerosis [0.03%]
STING介导的神经元炎症应激反应与多发性硬化症发病相关
Marcel S Woo,Christina Mayer,Lars Binkle-Ladisch et al.
Marcel S Woo et al.
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress response, we discovered that neurons in MS and its mouse m...
NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation [0.03%]
NLRC5感应NAD+缺乏，形成PANoptosome并驱动PANoptosis和炎症反应
Balamurugan Sundaram,Nagakannan Pandian,Hee Jin Kim et al.
Balamurugan Sundaram et al.
NLRs constitute a large, highly conserved family of cytosolic pattern recognition receptors that are central to health and disease, making them key therapeutic targets. NLRC5 is an enigmatic NLR with mutations associated with inflammatory a...
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms [0.03%]
人兽共患病原体交互图谱揭示致病机制
Thomas M Hart,Nicole D Sonnert,Xiaotian Tang et al.
Thomas M Hart et al.
Vector-borne diseases are a leading cause of death worldwide and pose a substantial unmet medical need. Pathogens binding to host extracellular proteins (the "exoproteome") represents a crucial interface in the etiology of vector-borne dise...
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors [0.03%]
纠正树突状细胞的年龄相关缺陷可使CD4+T细胞根除肿瘤
Dania Zhivaki,Stephanie N Kennedy,Josh Park et al.
Dania Zhivaki et al.
Defective host defenses later in life are associated with changes in immune cell activities, suggesting that age-specific considerations are needed in immunotherapy approaches. In this study, we found that PD-1 and CTLA4-based cancer immuno...
A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis [0.03%]
一种假常染色体糖基化障碍促使对多利醇生物合成进行修正
Matthew P Wilson,Takfarinas Kentache,Charlotte R Althoff et al.
Matthew P Wilson et al.
Published Erratum
Cell. 2024 Jul 11;187(14):3784. DOI:10.1016/j.cell.2024.06.004 2024
Retraction Notice to: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers [0.03%]
撤稿：由刺激特异性NPAS4异二聚体对神经去极化进行基因组解码的通知
G Stefano Brigidi,Michael G B Hayes,Nathaniel P Delos Santos et al.
G Stefano Brigidi et al.
Retraction of Publication
Cell. 2024 Jul 11;187(14):3785. DOI:10.1016/j.cell.2024.06.008 2024
Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa [0.03%]
单分子成像揭示了多细胞动物双向复制起始的机制
Riki Terui,Scott E Berger,Larissa A Sambel et al.
Riki Terui et al.
Metazoan genomes are copied bidirectionally from thousands of replication origins. Replication initiation entails the assembly and activation of two CMG helicases (Cdc45⋅Mcm2-7⋅GINS) at each origin. This requires several replication firin...
Chris Greening,Princess R Cabotaje,Luis E Valentin Alvarado et al.
Chris Greening et al.
Microbial hydrogen (H2) cycling underpins the diversity and functionality of diverse anoxic ecosystems. Among the three evolutionarily distinct hydrogenase superfamilies responsible, [FeFe] hydrogenases were thought to be restricted to bact...
TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons [0.03%]
TNF-NF-κB-p53信号轴限制人多能干细胞来源的黑质多巴胺神经元体内存活
Tae Wan Kim,So Yeon Koo,Markus Riessland et al.
Tae Wan Kim et al.
Ongoing, early-stage clinical trials illustrate the translational potential of human pluripotent stem cell (hPSC)-based cell therapies in Parkinson's disease (PD). However, an unresolved challenge is the extensive cell death following trans...
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies [0.03%]
利用设计的寡聚组合调控FGF信号通路及血管分化
Natasha I Edman,Ashish Phal,Rachel L Redler et al.
Natasha I Edman et al.
Many growth factors and cytokines signal by binding to the extracellular domains of their receptors and driving association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling casc...