Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD [0.03%]
ALS和FTLD中人类运动皮层和前额叶皮层的单细胞分析
S Sebastian Pineda,Hyeseung Lee,Maria J Ulloa-Navas et al.
S Sebastian Pineda et al.
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) share many clinical, pathological, and genetic features, but a detailed understanding of their associated transcriptional alterations across vulnerable cortica...
Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection [0.03%]
肺部感染期间生物膜外多糖改变感觉神经元介导的不适感
Elise Granton,Luke Brown,Manon Defaye et al.
Elise Granton et al.
Infections of the lung cause observable sickness thought to be secondary to inflammation. Signs of sickness are crucial to alert others via behavioral-immune responses to limit contact with contagious individuals. Gram-negative bacteria pro...
Task-driven neural network models predict neural dynamics of proprioception [0.03%]
任务驱动的神经网络模型预测本体感觉神经动力学
Alessandro Marin Vargas,Axel Bisi,Alberto S Chiappa et al.
Alessandro Marin Vargas et al.
Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task-driven modeling approach to investigate the n...
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology [0.03%]
少突胶质细胞在进化中的神经炎症病变和多发性硬化病理中的细胞架构
Petra Kukanja,Christoffer M Langseth,Leslie A Rubio Rodríguez-Kirby et al.
Petra Kukanja et al.
Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and smoldering pathology. Although single-cell analyses provided insights into cytopathology, evolving cellular processes underlying MS remain poorly unde...
Yiqing Wei,Renjie Li,Yufei Meng et al.
Yiqing Wei et al.
The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft. Given its close association with glutamate/glycine co-activated NMDA r...
Yilong Zhou,Amol Panhale,Maria Shvedunova et al.
Yilong Zhou et al.
Biomolecules incur damage during stress conditions, and damage partitioning represents a vital survival strategy for cells. Here, we identified a distinct stress granule (SG), marked by dsRNA helicase DHX9, which compartmentalizes ultraviol...
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes [0.03%]
人神经元和少突胶质细胞体细胞突变模式的差异性分析
Javier Ganz,Lovelace J Luquette,Sara Bizzotto et al.
Javier Ganz et al.
Characterizing somatic mutations in the brain is important for disentangling the complex mechanisms of aging, yet little is known about mutational patterns in different brain cell types. Here, we performed whole-genome sequencing (WGS) of 8...
Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient [0.03%]
大分子凝聚调控核仁亚相以建立pH梯度
Matthew R King,Kiersten M Ruff,Andrew Z Lin et al.
Matthew R King et al.
Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks interspersed by E-rich regions, as defining features of nuc...
Xiaoli Hu,Fengyi Chen,Liangjie Jia et al.
Xiaoli Hu et al.
The reciprocal coordination between cholesterol absorption in the intestine and de novo cholesterol synthesis in the liver is essential for maintaining cholesterol homeostasis, yet the mechanisms governing the opposing regulation of these p...
Type-I-interferon-responsive microglia shape cortical development and behavior [0.03%]
I型干扰素反应的小胶质细胞影响皮层发育和行为
Caroline C Escoubas,Leah C Dorman,Phi T Nguyen et al.
Caroline C Escoubas et al.
Microglia are brain-resident macrophages that shape neural circuit development and are implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have been defined, but their functional significance is unclear. He...