Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging [0.03%]
利用瞬时适配器进行高通量多重超分辨率成像以解析细胞复杂性
Florian Schueder,Felix Rivera-Molina,Maohan Su et al.
Florian Schueder et al.
Mapping the intricate spatial relationships between the many different molecules inside a cell is essential to understanding cellular functions in all their complexity. Super-resolution fluorescence microscopy offers the required spatial re...
Structure-guided discovery of protein and glycan components in native mastigonemes [0.03%]
结构导向的发现天然鞭毛饰物中的蛋白质和糖链成分
Junhao Huang (黄隽豪),Hui Tao (陶慧),Jikun Chen (陈继坤) et al.
Junhao Huang (黄隽豪) et al.
Mastigonemes, the hair-like lateral appendages lining cilia or flagella, participate in mechanosensation and cellular motion, but their constituents and structure have remained unclear. Here, we report the cryo-EM structure of native mastig...
K Verkerk,E E Voest
K Verkerk
The precision oncology paradigm challenges the feasibility and data generalizability of traditional clinical trials. Consequently, an unmet need exists for practical approaches to test many subgroups, evaluate real-world drug value, and gat...
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment [0.03%]
癌症生物标志物：新兴趋势及个性化治疗的临床意义
Antonio Passaro,Maise Al Bakir,Emily G Hamilton et al.
Antonio Passaro et al.
The integration of cancer biomarkers into oncology has revolutionized cancer treatment, yielding remarkable advancements in cancer therapeutics and the prognosis of cancer patients. The development of personalized medicine represents a turn...
Charles Swanton,Elsa Bernard,Chris Abbosh et al.
Charles Swanton et al.
The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifest...
Lia Gore,Maureen M O&#x;Brien
Lia Gore
Dramatic progress in treating childhood cancer has evolved over decades from initial empirically derived treatments to clinical investigations incorporating disease biology with rationally designed therapeutic programs. While cure is now po...
Challenges and opportunities in oncology drug development and clinical research in China [0.03%]
中国肿瘤药物研发和临床研究的挑战与机遇
Feng Wang,Dan-Yun Ruan,Rui-Hua Xu
Feng Wang
As one of the world's most populous countries, China bears a heavy burden and a broad spectrum of cancers, including unique types, providing a unique environment for drug research and development. In recent years, China has leapt forward in...
Robert A Weinberg
Robert A Weinberg
Discoveries of the roles of RAS oncogenes in cancer development four decades ago opened the door to proving that tumor development is driven by somatic mutations' altering the genomes of cancer cells. These discoveries led to illusions abou...
Moshe Oren,Carol Prives
Moshe Oren
The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet l...
Cell editorial team
Cell editorial team
Over the past 50 years, our understanding of cancer has evolved from its viral origin to a complex systemic disease. Along the way, improved diagnosis and therapeutics saved millions of lives. To mark Cell's 50th anniversary, this focus iss...