Infant microbes and metabolites point to childhood neurodevelopmental disorders [0.03%]
婴儿微生物和代谢物与儿童神经发育障碍的关系
Angelica P Ahrens,Tuulia Hyötyläinen,Joseph R Petrone et al.
Angelica P Ahrens et al.
This study has followed a birth cohort for over 20 years to find factors associated with neurodevelopmental disorder (ND) diagnosis. Detailed, early-life longitudinal questionnaires captured infection and antibiotic events, stress, prenatal...
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria [0.03%]
弗雷明汉心脏研究中的肠道微生物组和代谢组谱分析揭示了胆固醇代谢细菌
Chenhao Li,Martin Stražar,Ahmed M T Mohamed et al.
Chenhao Li et al.
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered by lack of matched multi-omic data with diagnostic biomarkers. T...
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling [0.03%]
绘制结肠炎细胞生物地理图谱揭示成纤维细胞轨迹及空间重塑的协调作用
Paolo Cadinu,Kisha N Sivanathan,Aditya Misra et al.
Paolo Cadinu et al.
Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cell...
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells [0.03%]
癌细胞源性Tau通过SLC6A6介导的CD8+t细胞 Tau摄取促进免疫检查点基因表达及T细胞衰竭诱导作用
Tianyu Cao,Wenyao Zhang,Qi Wang et al.
Tianyu Cao et al.
Taurine is used to bolster immunity, but its effects on antitumor immunity are unclear. Here, we report that cancer-related taurine consumption causes T cell exhaustion and tumor progression. The taurine transporter SLC6A6 is correlated wit...
Barcoding of episodic memories in the hippocampus of a food-caching bird [0.03%]
食储鸟海马脑中关于时序记忆的条形码机制神经系统实验研究
Selmaan N Chettih,Emily L Mackevicius,Stephanie Hale et al.
Selmaan N Chettih et al.
The hippocampus is critical for episodic memory. Although hippocampal activity represents place and other behaviorally relevant variables, it is unclear how it encodes numerous memories of specific events in life. To study episodic coding, ...
The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity [0.03%]
SPATA5-SPATA5L1解旋酶复合体调控复制叉蛋白稳态以维持基因组稳定性
Vidhya Krishnamoorthy,Martina Foglizzo,Robert L Dilley et al.
Vidhya Krishnamoorthy et al.
Ubiquitin-dependent unfolding of the CMG helicase by VCP/p97 is required to terminate DNA replication. Other replisome components are not processed in the same fashion, suggesting that additional mechanisms underlie replication protein turn...
Flexible scaffold-based cheminformatics approach for polypharmacological drug design [0.03%]
基于灵活支架的化学信息学方法在多药理药物设计中的应用
Zhangcheng Chen,Jing Yu,Huan Wang et al.
Zhangcheng Chen et al.
Effective treatments for complex central nervous system (CNS) disorders require drugs with polypharmacology and multifunctionality, yet designing such drugs remains a challenge. Here, we present a flexible scaffold-based cheminformatics app...
Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices [0.03%]
甲壳膜蛋白结构揭示了原生羟脯氨酸丰富螺旋O-聚糖的编码规则
Jin Dai,Meisheng Ma,Qingwei Niu et al.
Jin Dai et al.
Hydroxyproline-rich glycoproteins (HRGPs) are a ubiquitous class of protein in the extracellular matrices and cell walls of plants and algae, yet little is known of their native structures or interactions. Here, we used electron cryomicrosc...
Hua Qiu,Xiandeng Wu,Xiaoli Ma et al.
Hua Qiu et al.
In addition to long-distance molecular motor-mediated transport, cellular vesicles also need to be moved at short distances with defined directions to meet functional needs in subcellular compartments but with unknown mechanisms. Such short...
Eduard M Unterauer,Sayedali Shetab Boushehri,Kristina Jevdokimenko et al.
Eduard M Unterauer et al.
To understand biological processes, it is necessary to reveal the molecular heterogeneity of cells by gaining access to the location and interaction of all biomolecules. Significant advances were achieved by super-resolution microscopy, but...