Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells [0.03%]
时间分辨谱系示踪鉴定出肠道上部隐窝区是Lgr5阳性隐窝基底柱状细胞的起源地
Claudia Capdevila,Jonathan Miller,Liang Cheng et al.
Claudia Capdevila et al.
In the prevailing model, Lgr5+ cells are the only intestinal stem cells (ISCs) that sustain homeostatic epithelial regeneration by upward migration of progeny through elusive upper crypt transit-amplifying (TA) intermediates. Here, we ident...
A developmental constraint model of cancer cell states and tumor heterogeneity [0.03%]
发育约束下的癌细胞状态及肿瘤异质性模型
Ayushi S Patel,Itai Yanai
Ayushi S Patel
Cancer is a disease that stems from a fundamental liability inherent to multicellular life forms in which an individual cell is capable of reneging on the interests of the collective organism. Although cancer is commonly described as an evo...
Sergey Kryazhimskiy
Sergey Kryazhimskiy
Microbial communities perform many important functions, such as carbon sequestration, decomposition, pathogen resistance, etc., but quantitatively predicting functions of new communities remains a major challenge. In this issue of Cell, Dia...
Poulami Chatterjee,Laura M K Dassama
Poulami Chatterjee
Gut microbes are known to impact host physiology in several ways. However, key molecular players in host-commensal interactions remain to be uncovered. In this issue of Cell, McCurry et al. reveal that gut bacteria perform 21-dehydroxylatio...
Mei-Lan Li,Kaelyn Sumigray
Mei-Lan Li
In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al.1 and Malagola, Vasciaveo, et al.2 identify a new ISC population in the upper cry...
On mechanical phase and form [0.03%]
论机械的相和形
Windie Höfs,Sara A Wickström
Windie Höfs
Epithelial folding is a fundamental biological process that requires epithelial interactions with the underlying mesenchyme. In this issue of Cell, Huycke et al. investigate intestinal villus formation. They discover that water-droplet-like...
Silvia Sookoian,Carlos Jose Pirola
Silvia Sookoian
Resmetirom is an oral selective THR-β agonist conditionally approved for the treatment of patients with noncirrhotic MASH with moderate to advanced fibrosis. Resmetirom restores mitochondrial and hepatic metabolic function; reduces atherog...
Discovery of antimicrobial peptides in the global microbiome with machine learning [0.03%]
基于机器学习在地球微生物组中发现抗菌肽
Célio Dias Santos-Júnior,Marcelo D T Torres,Yiqian Duan et al.
Célio Dias Santos-Júnior et al.
Novel antibiotics are urgently needed to combat the antibiotic-resistance crisis. We present a machine-learning-based approach to predict antimicrobial peptides (AMPs) within the global microbiome and leverage a vast dataset of 63,410 metag...
The ribotoxic stress response drives UV-mediated cell death [0.03%]
核转录因子κB活化剂的“ribotoxic”应激反应介导紫外线诱导的细胞死亡
Niladri K Sinha,Connor McKenney,Zhong Y Yeow et al.
Niladri K Sinha et al.
While ultraviolet (UV) radiation damages DNA, eliciting the DNA damage response (DDR), it also damages RNA, triggering transcriptome-wide ribosomal collisions and eliciting a ribotoxic stress response (RSR). However, the relative contributi...
Shiyu Li,Min Yang,Hui Shen et al.
Shiyu Li et al.
The cleavage of zygotes generates totipotent blastomeres. In human 8-cell blastomeres, zygotic genome activation (ZGA) occurs to initiate the ontogenesis program. However, capturing and maintaining totipotency in human cells pose significan...