A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2 [0.03%]
一种糖酵解代谢物绕过BRCA2“两次打击”肿瘤抑制作用
Li Ren Kong,Komal Gupta,Andy Jialun Wu et al.
Li Ren Kong et al.
Knudson's "two-hit" paradigm posits that carcinogenesis requires inactivation of both copies of an autosomal tumor suppressor gene. Here, we report that the glycolytic metabolite methylglyoxal (MGO) transiently bypasses Knudson's paradigm b...
Michael A Fischbach
Michael A Fischbach
Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for evaluating impact and likelihood of success...
W Marcus Lambert,Marlene Camacho-Rivera,Carla Boutin-Foster et al.
W Marcus Lambert et al.
"Helicopter research" refers to a practice where researchers from wealthier countries conduct studies in lower-income countries with little involvement of local researchers or community members. This practice also occurs domestically. In th...
Christopher J Wayne,Anna K Blakney
Christopher J Wayne
In November 2023, Japan's Ministry of Health, Labour and Welfare granted regulatory approval of ARCT-154, a self-amplifying RNA COVID-19 vaccine developed by Arcturus Therapeutics. Clinical trials showed comparable safety and efficacy using...
Nancy Raab-Traub,Benjamin E Gewurz
Nancy Raab-Traub
Time-series reconstruction of the molecular architecture of human centriole assembly [0.03%]
人中心粒组装分子结构的时空重构
Marine H Laporte,Davide Gambarotto,Éloïse Bertiaux et al.
Marine H Laporte et al.
Centriole biogenesis, as in most organelle assemblies, involves the sequential recruitment of sub-structural elements that will support its function. To uncover this process, we correlated the spatial location of 24 centriolar proteins with...
Thomas W Battaglia,Iris L Mimpen,Joleen J H Traets et al.
Thomas W Battaglia et al.
Microbial communities are resident to multiple niches of the human body and are important modulators of the host immune system and responses to anticancer therapies. Recent studies have shown that complex microbial communities are present w...
A genome-wide spectrum of tandem repeat expansions in 338,963 humans [0.03%]
人类基因组中串联重复序列扩增的全基因组谱系研究
Ya Cui,Wenbin Ye,Jason Sheng Li et al.
Ya Cui et al.
The Genome Aggregation Database (gnomAD), widely recognized as the gold-standard reference map of human genetic variation, has largely overlooked tandem repeat (TR) expansions, despite the fact that TRs constitute ∼6% of our genome and are...
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation [0.03%]
人类iPSCTau病模型发现tau蛋白传播的调节因子
Celeste Parra Bravo,Alice Maria Giani,Jesus Madero-Perez et al.
Celeste Parra Bravo et al.
Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal ...
Kuo Liu,Xinfeng Meng,Zixin Liu et al.
Kuo Liu et al.
Alveolar type 2 (AT2) cells are stem cells of the alveolar epithelia. Previous genetic lineage tracing studies reported multiple cellular origins for AT2 cells after injury. However, conventional lineage tracing based on Cre-loxP has the li...