Immunology is for everyone [0.03%]
免疫学与你我相关
Cell editorial team
Cell editorial team
This "Focus on Immunology" issue brings Cell's 50th anniversary celebrations straight to your lymph nodes! Special Leading Edge articles highlight the exciting past, present, and future of the increasingly interdisciplinary field of immunol...
Synthetic protein circuits for programmable control of mammalian cell death [0.03%]
合成蛋白质电路程序控制哺乳动物细胞凋亡
Shiyu Xia,Andrew C Lu,Victoria Tobin et al.
Shiyu Xia et al.
Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate harmful cells and modulate the immune system by dampening or stimulating inflammation. Synthetic protein circuits capable of triggering specific de...
Zhenyu Xiao,Lina Cui,Yang Yuan et al.
Zhenyu Xiao et al.
Progress in understanding early human development has been impeded by the scarcity of reference datasets from natural embryos, particularly those with spatial information during crucial stages like gastrulation. We conducted high-resolution...
IGSF8 is an innate immune checkpoint and cancer immunotherapy target [0.03%]
IGSF8是一个先天免疫检查点和癌症免疫治疗靶标
Yulong Li,Xiangyang Wu,Caibin Sheng et al.
Yulong Li et al.
Antigen presentation defects in tumors are prevalent mechanisms of adaptive immune evasion and resistance to cancer immunotherapy, whereas how tumors evade innate immunity is less clear. Using CRISPR screens, we discovered that IGSF8 expres...
Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program [0.03%]
表观转录组学程序区分造血干细胞龛的生成和维持
Longfei Gao,Heather Lee,Joshua H Goodman et al.
Longfei Gao et al.
The niche is typically considered as a pre-established structure sustaining stem cells. Therefore, the regulation of its formation remains largely unexplored. Whether distinct molecular mechanisms control the establishment versus maintenanc...
Continuous germinal center invasion contributes to the diversity of the immune response [0.03%]
连续的生发中心侵染促进了免疫反应的多样性
Thomas Hägglöf,Melissa Cipolla,Maximilian Loewe et al.
Thomas Hägglöf et al.
Published Erratum
Cell. 2024 May 23;187(11):2893. DOI:10.1016/j.cell.2024.04.004 2024
BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis [0.03%]
褐色脂肪中的 BCAA 氮通量调控代谢健康（与产生热量无关）
Anthony R P Verkerke,Dandan Wang,Naofumi Yoshida et al.
Anthony R P Verkerke et al.
Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis is tightly associated with increased energy expenditure, reduced body weight, and improved glucose homeostasis. However,...
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway [0.03%]
肠道共生菌通过次级胆汁酸生物合成途径缓解MASH现象
Qixing Nie,Xi Luo,Kai Wang et al.
Qixing Nie et al.
The gut microbiota has been found to play an important role in the progression of metabolic dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been established. Here, by developing a click-chemistry-based enrichment ...
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis [0.03%]
天冬氨酰-tRNA合成酶AARS1是一种乳酸感受器和p53乳酰化酶，可促进肿瘤发生
Zhi Zong,Feng Xie,Shuai Wang et al.
Zhi Zong et al.
Lysine lactylation is a post-translational modification that links cellular metabolism to protein function. Here, we find that AARS1 functions as a lactate sensor that mediates global lysine lacylation in tumor cells. AARS1 binds to lactate...
Mariko Takahashi,Harrison B Chong,Siwen Zhang et al.
Mariko Takahashi et al.
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To...