Amander T Clark,Janet Rossant,Robin Lovell-Badge
Amander T Clark
In the rapidly moving field of stem cell and embryo research, research questions often sit at the intersection of scientific inquiry and ethical considerations. The International Society for Stem Cell Research (ISSCR) produces guidelines to...
Parsing patterns: Emerging roles of tissue self-organization in health and disease [0.03%]
解析模式：组织自组织在健康和疾病中作用的新角色
Raul Ramos,Benjamin Swedlund,Anand K Ganesan et al.
Raul Ramos et al.
Patterned morphologies, such as segments, spirals, stripes, and spots, frequently emerge during embryogenesis through self-organized coordination between cells. Yet, complex patterns also emerge in adults, suggesting that the capacity for s...
Cell Editorial team
Cell Editorial team
Awe-inspiring developmental biology is all around us. In this 50th Anniversary focus issue, we celebrate developmental biology with content paying homage to the incredible progress the field has witnessed over the last five decades as well ...
Francesco Andreata,Chiara Laura,Micol Ravà et al.
Francesco Andreata et al.
Reversing CD8+ T cell dysfunction is crucial in treating chronic hepatitis B virus (HBV) infection, yet specific molecular targets remain unclear. Our study analyzed co-signaling receptors during hepatocellular priming and traced the trajec...
Xingcong Jiang,Eleftherios Dimitriou,Veit Grabe et al.
Xingcong Jiang et al.
The representation of odors in the locust antennal lobe with its >2,000 glomeruli has long remained a perplexing puzzle. We employed the CRISPR-Cas9 system to generate transgenic locusts expressing the genetically encoded calcium indicator ...
The genomic and cellular basis of biosynthetic innovation in rove beetles [0.03%]
小型步甲昆虫次生代谢产物生物合成创新的基因组和细胞基础
Sheila A Kitchen,Thomas H Naragon,Adrian Brückner et al.
Sheila A Kitchen et al.
How evolution at the cellular level potentiates macroevolutionary change is central to understanding biological diversification. The >66,000 rove beetle species (Staphylinidae) form the largest metazoan family. Combining genomic and cell ty...
A metabolomics pipeline highlights microbial metabolism in bloodstream infections [0.03%]
一种代谢组学流程可揭示血流感染中的微生物代谢作用
Jared R Mayers,Jack Varon,Ruixuan R Zhou et al.
Jared R Mayers et al.
The growth of antimicrobial resistance (AMR) highlights an urgent need to identify bacterial pathogenic functions that may be targets for clinical intervention. Although severe infections profoundly alter host metabolism, prior studies have...
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis [0.03%]
STING介导的神经元炎症应激反应与多发性硬化症发病相关
Marcel S Woo,Christina Mayer,Lars Binkle-Ladisch et al.
Marcel S Woo et al.
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress response, we discovered that neurons in MS and its mouse m...
NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation [0.03%]
NLRC5感应NAD+缺乏，形成PANoptosome并驱动PANoptosis和炎症反应
Balamurugan Sundaram,Nagakannan Pandian,Hee Jin Kim et al.
Balamurugan Sundaram et al.
NLRs constitute a large, highly conserved family of cytosolic pattern recognition receptors that are central to health and disease, making them key therapeutic targets. NLRC5 is an enigmatic NLR with mutations associated with inflammatory a...
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms [0.03%]
人兽共患病原体交互图谱揭示致病机制
Thomas M Hart,Nicole D Sonnert,Xiaotian Tang et al.
Thomas M Hart et al.
Vector-borne diseases are a leading cause of death worldwide and pose a substantial unmet medical need. Pathogens binding to host extracellular proteins (the "exoproteome") represents a crucial interface in the etiology of vector-borne dise...