TERT activation targets DNA methylation and multiple aging hallmarks [0.03%]
端粒酶反转录酶的激活作用于DNA甲基化和多种衰老标志物
Hong Seok Shim,Jonathan Iaconelli,Xiaoying Shang et al.
Hong Seok Shim et al.
Insufficient telomerase activity, stemming from low telomerase reverse transcriptase (TERT) gene transcription, contributes to telomere dysfunction and aging pathologies. Besides its traditional function in telomere synthesis, TERT acts as ...
The evolution of developmental biology through conceptual and technological revolutions [0.03%]
概念和技术变革驱动的发展生物学演进
Prisca Liberali,Alexander F Schier
Prisca Liberali
Developmental biology-the study of the processes by which cells, tissues, and organisms develop and change over time-has entered a new golden age. After the molecular genetics revolution in the 80s and 90s and the diversification of the fie...
Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome [0.03%]
基于肠道微生物生态拓扑的免疫治疗响应定制评分系统
Lisa Derosa,Valerio Iebba,Carolina Alves Costa Silva et al.
Lisa Derosa et al.
The gut microbiota influences the clinical responses of cancer patients to immunecheckpoint inhibitors (ICIs). However, there is no consensus definition of detrimental dysbiosis. Based on metagenomics (MG) sequencing of 245 non-small cell l...
FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis [0.03%]
丝状体识别在配子发生过程中代谢酶聚合物的组成和功能
Jannik Hugener,Jingwei Xu,Rahel Wettstein et al.
Jannik Hugener et al.
Gamete formation and subsequent offspring development often involve extended phases of suspended cellular development or even dormancy. How cells adapt to recover and resume growth remains poorly understood. Here, we visualized budding yeas...
Xiaolin Huang,Yang Dan
Xiaolin Huang
Somatic and sympathetic tones fluctuate together seamlessly across daily behaviors. In this issue of Cell, Zhang et al. describe populations of spinal projecting neurons in the rostral ventromedial medulla (rVMM) that harmonize somatic moto...
Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy [0.03%]
肠道微生物组生态拓扑将成为癌症免疫治疗的下一代生物标志物
Lijun Ning,Jie Hong
Lijun Ning
Numerous studies have evaluated the gut microbiome as a biomarker for predicting cancer immunotherapy, but the heterogeneity among different studies has hindered its applications. In this issue of Cell, Derosa et al. report a biomarker base...
Shinya Yamanaka [0.03%]
山中申彥
Shinya Yamanaka
Shinya Yamanaka
Dr. Shinya Yamanaka is recognized for his discovery of the induction of pluripotent stem cells from fibroblasts by a combination of defined factors. In this interview with Cell, he discusses the progress of the field, what's next for clinic...
Jennifer Lewis,Melina Schuh,Jacob H Hanna et al.
Jennifer Lewis et al.
The next 50 years of developmental biology will illuminate exciting new discoveries but are also poised to provide solutions to important problems society faces. Ten scientists whose work intersects with developmental biology in various cap...
Insoo Hyun
Insoo Hyun
Stem cells can be coaxed to self-organize into dynamic models of human development and early embryo formation. Despite their scientific promise, might widespread use of these technologies alter people's beliefs about what it means to be a h...
Jun Wu,Jianping Fu
Jun Wu
Developing functional organs from stem cells remains a challenging goal in regenerative medicine. Existing methodologies, such as tissue engineering, bioprinting, and organoids, only offer partial solutions. This perspective focuses on two ...