Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB [0.03%]
正向选择CRISPR筛选发现了一个糖基转移酶中的可药用口袋，该转移酶对NF-κB的炎性信号传导是必需的
Benjamin L Lampson,Ana S Ramίrez,Marta Baro et al.
Benjamin L Lampson et al.
Nuclear factor κB (NF-κB) plays roles in various diseases. Many inflammatory signals, such as circulating lipopolysaccharides (LPSs), activate NF-κB via specific receptors. Using whole-genome CRISPR-Cas9 screens of LPS-treated cells that...
Benjamin T Throesch,Muhammad Khadeesh Bin Imtiaz,Rodrigo Muñoz-Castañeda et al.
Benjamin T Throesch et al.
A central question for regenerative neuroscience is whether synthetic neural circuits, such as those built from two species, can function in an intact brain. Here, we apply blastocyst complementation to selectively build and test interspeci...
Jia Huang,Bingbing He,Xiali Yang et al.
Jia Huang et al.
Interspecies blastocyst complementation (IBC) provides a unique platform to study development and holds the potential to overcome worldwide organ shortages. Despite recent successes, brain tissue has not been achieved through IBC. Here, we ...
Chi Chun Wong,Jun Yu
Chi Chun Wong
The landscape of the intratumoral microbiome in tumor metastases is largely unchartered. In this issue of Cell, Voest et al. profiled the tumor metastasis-associated microbiome in a pancancer cohort of 4,160 biopsies from 26 cancer types. T...
Peng Jiang
Peng Jiang
Many types of tumor cells alter metabolic pathways to meet their energy and biosynthetic demands for proliferation or stress adaptation. In this issue of Cell, Kong et al. find that the glycolytic metabolite methylglyoxal causes cancer-asso...
Ana J García-Sáez,Ana I Domingos,J Silvio Gutkind et al.
Ana J García-Sáez et al.
While some people pore over the textbook and train through the classics of the field, many scientists come to immunology when they discover it intersecting with their "first love" interests. Five of these "accidental immunologists" tell us ...
Jonathan D G Jones,Brian J Staskawicz,Jeffery L Dangl
Jonathan D G Jones
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to spec...
Ruslan Medzhitov,Akiko Iwasaki
Ruslan Medzhitov
Several conceptual pillars form the foundation of modern immunology, including the clonal selection theory, antigen receptor diversity, immune memory, and innate control of adaptive immunity. However, some immunological phenomena cannot be ...
Hongbo Chi,Marion Pepper,Paul G Thomas
Hongbo Chi
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we revi...
From periphery to center stage: 50 years of advancements in innate immunity [0.03%]
从中枢到中心舞台：先天免疫50年的研究进展
Susan Carpenter,Luke A J O&#x;Neill
Susan Carpenter
Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely specific activi...