Hanlin Zhang,C Kimberly Tsui,Gilberto Garcia et al.
Hanlin Zhang et al.
Cellular homeostasis is intricately influenced by stimuli from the microenvironment, including signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the cell, mitochondria integrate information from various ...
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain [0.03%]
小胶质细胞源性C1q整合到衰老大脑的神经rna结合蛋白复合物中并影响蛋白质稳态
Nicole Scott-Hewitt,Matthew Mahoney,Youtong Huang et al.
Nicole Scott-Hewitt et al.
Neuroimmune interactions mediate intercellular communication and underlie critical brain functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical interactions and the secretion of molecules. One such secret...
Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1 [0.03%]
由泛素相关修饰酶Urm1调控的应激依赖性凝聚体形成
Lucas V Cairo,Xiaoyu Hong,Martin B D Müller et al.
Lucas V Cairo et al.
The ability of proteins and RNA to coalesce into phase-separated assemblies, such as the nucleolus and stress granules, is a basic principle in organizing membraneless cellular compartments. While the constituents of biomolecular condensate...
Preclinical proof of principle for orally delivered Th17 antagonist miniproteins [0.03%]
口服递送Th17拮抗性迷你蛋白的药代动力学和药效学原理的验证研究
Stephanie Berger,Franziska Seeger,Ta-Yi Yu et al.
Stephanie Berger et al.
Interleukin (IL)-23 and IL-17 are well-validated therapeutic targets in autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical efficacy but are limited by high costs, safety risks, lack of sustained efficacy, an...
Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale [0.03%]
扩增编辑可在从短片段到兆碱基和染色体规模的任意DNA中实现高效精准复制
Ruiwen Zhang,Zhou He,Yajing Shi et al.
Ruiwen Zhang et al.
Duplication is a foundation of molecular evolution and a driver of genomic and complex diseases. Here, we develop a genome editing tool named Amplification Editing (AE) that enables programmable DNA duplication with precision at chromosomal...
Multiplexed single-cell characterization of alternative polyadenylation regulators [0.03%]
单细胞转录本切端位点的多重表征及调控机制分析
Madeline H Kowalski,Hans-Hermann Wessels,Johannes Linder et al.
Madeline H Kowalski et al.
Most mammalian genes have multiple polyA sites, representing a substantial source of transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To better understand how these proteins govern polyA site choice, we in...
The primitive endoderm supports lineage plasticity to enable regulative development [0.03%]
原始内胚叶支持谱系可塑性以实现调控发育
Madeleine Linneberg-Agerholm,Annika Charlotte Sell,Alba Redó-Riveiro et al.
Madeleine Linneberg-Agerholm et al.
Mammalian blastocyst formation involves the specification of the trophectoderm followed by the differentiation of the inner cell mass into embryonic epiblast and extra-embryonic primitive endoderm (PrE). During this time, the embryo maintai...
Marie Schott,Daniel León-Periñán,Elena Splendiani et al.
Marie Schott et al.
Spatial transcriptomics (ST) methods unlock molecular mechanisms underlying tissue development, homeostasis, or disease. However, there is a need for easy-to-use, high-resolution, cost-efficient, and 3D-scalable methods. Here, we report Ope...
Sara R Savage,Xinpei Yi,Jonathan T Lei et al.
Sara R Savage et al.
Fewer than 200 proteins are targeted by cancer drugs approved by the Food and Drug Administration (FDA). We integrate Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomics data from 1,043 patients across 10 cancer types with a...
Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony [0.03%]
利用人群异步性系统化绘制衰老的基因调控网络
Matthias Eder,Olivier M F Martin,Natasha Oswal et al.
Matthias Eder et al.
In aging, physiologic networks decline in function at rates that differ between individuals, producing a wide distribution of lifespan. Though 70% of human lifespan variance remains unexplained by heritable factors, little is known about th...