Jiafeng Huang,Xiaolin Zhang,Xiaohua Nie et al.
Jiafeng Huang et al.
Latent membrane protein 1 (LMP1) is the primary oncoprotein of Epstein-Barr virus (EBV) and plays versatile roles in the EBV life cycle and pathogenesis. Despite decades of extensive research, the molecular basis for LMP1 folding, assembly,...
Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample [0.03%]
十万年前猛犸象皮肤样本中三维基因组结构的持久性
Marcela Sandoval-Velasco,Olga Dudchenko,Juan Antonio Rodríguez et al.
Marcela Sandoval-Velasco et al.
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus primigenius) that ...
Mari Kamiya,Hannah Carter,Milena S Espindola et al.
Mari Kamiya et al.
Fibrotic interstitial lung diseases (fILDs) have poor survival rates and lack effective therapies. Despite evidence for immune mechanisms in lung fibrosis, immunotherapies have been unsuccessful for major types of fILD. Here, we review immu...
Timing is everything: How plants optimize reproduction in a variable environment [0.03%]
时机很重要：植物如何在多变的环境中优化繁殖
David L Des Marais
David L Des Marais
Organisms experience a constantly changing environment and must adjust their development to maximize fitness. These "life histories" are fantastically diverse and have fascinated biologists for decades. Recent work published in Cell reveals...
Sarah E O&#x;Connor
Sarah E O&#x;Connor
Dolichol is a lipid that is involved in protein glycosylation, a process that is essential for all eukaryotic life. In this issue of Cell, Wilson and coworkers1 report how a rare human genetic disorder led to the discovery of dolichol biosy...
Advancing accessible science for low-vision and diverse-needs communities [0.03%]
推进低视力及各类特殊需求群体的无障碍科学教育与普及
Erica Tandori,Jamie Rossjohn
Erica Tandori
Science can often be inaccessible for people with disabilities, including those with low vision or blindness. Below, we hear from Jamie Rossjohn and Erica Tandori regarding the insights and experiences into the establishment of an internshi...
Michael J Johnston,John J Y Lee,Bo Hu et al.
Michael J Johnston et al.
Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed...
A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence [0.03%]
一种小核仁RNA在核糖体生物发生和衰老中发挥非典范作用
Yujing Cheng,Siwen Wang,He Zhang et al.
Yujing Cheng et al.
Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses, including aberrant oncogene activation, telomere shortening, and DNA damage. Through a genome-wide screen, we discovered a conserved small nucleo...
All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons [0.03%]
具有理性工程R2反向转座子的哺乳动物细胞全RNA介导的目标基因整合
Yangcan Chen,Shengqiu Luo,Yanping Hu et al.
Yangcan Chen et al.
All-RNA-mediated targeted gene integration methods, rendering reduced immunogenicity, effective deliverability with non-viral vehicles, and a low risk of random mutagenesis, are urgently needed for next-generation gene addition technologies...
Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries [0.03%]
来自32个国家的56,989名个体中的肠胞子虫与更健康的饮食和更有利的心脏代谢结局有关
Elisa Piperni,Long H Nguyen,Paolo Manghi et al.
Elisa Piperni et al.
Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-euk...