Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes [0.03%]
泛癌种单细胞解析揭示了不同表型的B细胞亚群
Yu Yang,Xueyan Chen,Jieying Pan et al.
Yu Yang et al.
Characterizing the compositional and phenotypic characteristics of tumor-infiltrating B cells (TIBs) is important for advancing our understanding of their role in cancer development. Here, we establish a comprehensive resource of human B ce...
Eftychios Frangedakis,Nataliya E Yelina,Kumari Billakurthi et al.
Eftychios Frangedakis et al.
Chloroplast biogenesis is dependent on master regulators from the GOLDEN2-LIKE (GLK) family of transcription factors. However, glk mutants contain residual chlorophyll, indicating that other proteins must be involved. Here, we identify MYB-...
Innate immune memory after brain injury drives inflammatory cardiac dysfunction [0.03%]
中枢神经系统损伤后的先天免疫记忆诱导心脏炎症损伤
Alba Simats,Sijia Zhang,Denise Messerer et al.
Alba Simats et al.
The medical burden of stroke extends beyond the brain injury itself and is largely determined by chronic comorbidities that develop secondarily. We hypothesized that these comorbidities might share a common immunological cause, yet chronic ...
Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit [0.03%]
小脑恐惧回路中的肽类神经递质作为初级神经递质的 presynaptic 传感器和抑制器
Dong-Il Kim,Sekun Park,Seahyung Park et al.
Dong-Il Kim et al.
Neurons produce and release neuropeptides to communicate with one another. Despite their importance in brain function, circuit-based mechanisms of peptidergic transmission are poorly understood, primarily due to the lack of tools for monito...
Jiaying Huang,Qiupeng Lin,Hongyuan Fei et al.
Jiaying Huang et al.
Published Erratum
Cell. 2024 Aug 8;187(16):4426-4428. DOI:10.1016/j.cell.2024.07.003 2024
From periphery to center stage: 50 years of advancements in innate immunity [0.03%]
从边缘到舞台中央：先天免疫五十年进展
Susan Carpenter,Luke A J O&#x;Neill
Susan Carpenter
Published Erratum
Cell. 2024 Aug 8;187(16):4429-4430. DOI:10.1016/j.cell.2024.07.010 2024
Integrated cryoEM structure of a spumaretrovirus reveals cross-kingdom evolutionary relationships and the molecular basis for assembly and virus entry [0.03%]
整合的冷冻电子显微镜结构揭示了泡沫病毒的跨王国进化关系及其组装和病毒感染的分子基础
Thomas Calcraft,Nicole Stanke-Scheffler,Andrea Nans et al.
Thomas Calcraft et al.
Foamy viruses (FVs) are an ancient lineage of retroviruses, with an evolutionary history spanning over 450 million years. Vector systems based on Prototype Foamy Virus (PFV) are promising candidates for gene and oncolytic therapies. Structu...
Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis [0.03%]
同种异体CD19靶向CAR-T治疗严重肌炎和系统性硬化症患者的疗效
Xiaobing Wang,Xin Wu,Binghe Tan et al.
Xiaobing Wang et al.
Allogeneic chimeric antigen receptor (CAR)-T cells hold great promise for expanding the accessibility of CAR-T therapy, whereas the risks of allograft rejection have hampered its application. Here, we genetically engineered healthy-donor-de...
Clinical Trial
Cell. 2024 Sep 5;187(18):4890-4904.e9. DOI:10.1016/j.cell.2024.06.027 2024
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins [0.03%]
具有酸性聚簇结构域的cargo蛋白受体-WDR11复合物
Huaqing Deng,Guowen Jia,Ping Li et al.
Huaqing Deng et al.
Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells. Cargo recognition primarily occurs through coats and the associated...
Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching [0.03%]
唐尤素信号在突触配对中的分子和细胞机制研究
Chuanyun Xu,Zhuoran Li,Cheng Lyu et al.
Chuanyun Xu et al.
In developing brains, axons exhibit remarkable precision in selecting synaptic partners among many non-partner cells. Evolutionarily conserved teneurins are transmembrane proteins that instruct synaptic partner matching. However, how intrac...