De novo and salvage purine synthesis pathways across tissues and tumors [0.03%]
从头和补救性嘌呤合成途径在组织和肿瘤中的作用
Diem H Tran,Dohun Kim,Rushendhiran Kesavan et al.
Diem H Tran et al.
Purine nucleotides are vital for RNA and DNA synthesis, signaling, metabolism, and energy homeostasis. To synthesize purines, cells use two principal routes: the de novo and salvage pathways. Traditionally, it is believed that proliferating...
A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis [0.03%]
一种假常染色体糖基化障碍促使对多胺生物合成的修订
Matthew P Wilson,Takfarinas Kentache,Charlotte R Althoff et al.
Matthew P Wilson et al.
Dolichol is a lipid critical for N-glycosylation as a carrier for activated sugars and nascent oligosaccharides. It is commonly thought to be directly produced from polyprenol by the enzyme SRD5A3. Instead, we found that dolichol synthesis ...
Taehong Yang,Daniel W Bayless,Yichao Wei et al.
Taehong Yang et al.
Published Erratum
Cell. 2024 Jul 11;187(14):3782. DOI:10.1016/j.cell.2024.05.046 2024
RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly [0.03%]
RNA质量控制因子能够聚集Clr4/SUV39H并触发组成型异染色质的形成
Jasbeer S Khanduja,Richard I Joh,Monica M Perez et al.
Jasbeer S Khanduja et al.
In eukaryotes, the Suv39 family of proteins tri-methylate lysine 9 of histone H3 (H3K9me) to form constitutive heterochromatin. However, how Suv39 proteins are nucleated at heterochromatin is not fully described. In the fission yeast, curre...
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior [0.03%]
与性别和发情周期依赖的基因表达和行为的功能性细胞框架
Joseph R Knoedler,Sayaka Inoue,Daniel W Bayless et al.
Joseph R Knoedler et al.
Published Erratum
Cell. 2024 Jul 11;187(14):3781. DOI:10.1016/j.cell.2024.05.045 2024
Fangyu Liu,Anat Levit Kaplan,Jesper Levring et al.
Fangyu Liu et al.
The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel whose loss of function leads to cystic fibrosis, whereas its hyperactivation leads to secretory diarrhea. Small molecules that improve CFTR folding (cor...
Reciprocal conversion between annual and polycarpic perennial flowering behavior in the Brassicaceae [0.03%]
蔊科植物一年生和多年生开花行为的互逆转变
Dong Zhai,Lu-Yi Zhang,Ling-Zi Li et al.
Dong Zhai et al.
The development of perennial crops holds great promise for sustainable agriculture and food security. However, the evolution of the transition between perenniality and annuality is poorly understood. Here, using two Brassicaceae species, Cr...
Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape [0.03%]
通过重塑古老的基因调控景观来演化非洲蓝树鱼的滞育现象
Param Priya Singh,G Adam Reeves,Kévin Contrepois et al.
Param Priya Singh et al.
Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolut...
Daniel W Bayless,Chung-Ha O Davis,Renzhi Yang et al.
Daniel W Bayless et al.
Published Erratum
Cell. 2024 Jul 11;187(14):3783. DOI:10.1016/j.cell.2024.05.047 2024
Limbic Neurons Shape Sex Recognition and Social Behavior in Sexually Naive Males [0.03%]
limbic神经元塑造性未成熟雄性的性别识别和社会行为
Daniel W Bayless,Taehong Yang,Matthew M Mason et al.
Daniel W Bayless et al.
Published Erratum
Cell. 2024 Jul 11;187(14):3779. DOI:10.1016/j.cell.2024.05.043 2024