The fork protection complex promotes parental histone recycling and epigenetic memory [0.03%]
叉保护复合体促进亲本组蛋白的循环和表观遗传记忆
Sebastian Jespersen Charlton,Valentin Flury,Yutaka Kanoh et al.
Sebastian Jespersen Charlton et al.
The inheritance of parental histones across the replication fork is thought to mediate epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3-H4 tetramers and operates as a central coordinator of symmetric p...
Activation of the helper NRC4 immune receptor forms a hexameric resistosome [0.03%]
NRC4 帮助性免疫受体活化形成抗性蛋白六聚体“抵抗osome”
Furong Liu,Zhenlin Yang,Chao Wang et al.
Furong Liu et al.
Innate immune responses to microbial pathogens are regulated by intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) in both the plant and animal kingdoms. Across plant innate immune systems, "helper" NLR...
Host and environmental factors shape upper airway microbiota and respiratory health across the human lifespan [0.03%]
宿主和环境因素塑造了上呼吸道微生物群并影响人类一生的呼吸健康状况
Mari-Lee Odendaal,Wouter A A de Steenhuijsen Piters,Eelco Franz et al.
Mari-Lee Odendaal et al.
Our understanding of the normal variation in the upper respiratory tract (URT) microbiota across the human lifespan and how these relate to host, environment, and health is limited. We studied the microbiota of 3,104 saliva (
Jiawei Shao,Xinyuan Qiu,Lihang Zhang et al.
Jiawei Shao et al.
So far, biocomputation strictly follows traditional design principles of digital electronics, which could reach their limits when assembling gene circuits of higher complexity. Here, by creating genetic variants of tristate buffers instead ...
The choroid plexus synergizes with immune cells during neuroinflammation [0.03%]
脉络丛在神经炎症期间与免疫细胞相互作用
Huixin Xu,Peter Lotfy,Sivan Gelb et al.
Huixin Xu et al.
The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF). Here, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics to elucidate the mechanisms of ChP regulation of brain inf...
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor [0.03%]
人类弗林明氏血型抗原受体的化学趋向性诱导机制及其功能发散现象的研究分子机理
Shirsha Saha,Basavraj Khanppnavar,Jagannath Maharana et al.
Shirsha Saha et al.
The Duffy antigen receptor is a seven-transmembrane (7TM) protein expressed primarily at the surface of red blood cells and displays strikingly promiscuous binding to multiple inflammatory and homeostatic chemokines. It serves as the basis ...
Extensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport [0.03%]
高度结构重组的鞭毛内运输列车支持双向物质运输
Samuel E Lacey,Andrea Graziadei,Gaia Pigino
Samuel E Lacey
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, called anterograde and retrograde intraflagellar transport (IFT) trains. Anterograde trains deliver cargoes from the cell to the cilium tip,...
I Sadaf Farooqi,Yong Xu
I Sadaf Farooqi
Obesity causes significant morbidity and mortality globally. Research in the last three decades has delivered a step-change in our understanding of the fundamental mechanisms that regulate energy homeostasis, building on foundational discov...
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5 [0.03%]
天然恶性疟原虫感染可诱发稀有但高效的针对RH5的中和抗体响应
Lawrence T Wang,Andrew J R Cooper,Brendan Farrell et al.
Lawrence T Wang et al.
Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is the most advanced blood-stage malaria vaccine candidate and is being evaluated for efficacy in endemic regions, emphasizing the need to study the underlying antibody resp...
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype [0.03%]
分析疟原虫配体RH5多样的抗原景观，鉴定出一个诱导产生强烈的疫苗抗体反应的公共克隆型抗体家族
Jordan R Barrett,Dimitra Pipini,Nathan D Wright et al.
Jordan R Barrett et al.
The highly conserved and essential Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has emerged as the leading target for vaccines against the disease-causing blood stage of malaria. However, the features of the human va...