Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity [0.03%]
LAG-3和PD-1阻滞使CD8+t细胞中的细胞毒性基因模块和耗竭基因模块共表达以促进抗肿瘤免疫反应
Anthony R Cillo,Carly Cardello,Feng Shan et al.
Anthony R Cillo et al.
Relatlimab (rela; anti-LAG-3) plus nivolumab (nivo; anti-PD-1) is safe and effective for treatment of advanced melanoma. We designed a trial (NCT03743766) where advanced melanoma patients received rela, nivo, or rela+nivo to interrogate the...
Clinical Trial
Cell. 2024 Aug 8;187(16):4373-4388.e15. DOI:10.1016/j.cell.2024.06.036 2024
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity [0.03%]
LAG-3和PD-1在CD8⁺T细胞上的协同作用促进耗竭并妨碍IFN-γ自分泌依赖性抗肿瘤免疫反应
Lawrence P Andrews,Samuel C Butler,Jian Cui et al.
Lawrence P Andrews et al.
Overcoming immune-mediated resistance to PD-1 blockade remains a major clinical challenge. Enhanced efficacy has been demonstrated in melanoma patients with combined nivolumab (anti-PD-1) and relatlimab (anti-LAG-3) treatment, the first in ...
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity [0.03%]
LAG-3维持TOX表达，并通过调节CD94/NKG2-Qa-1轴调控耗竭性CD8+T细胞NK受体的表达及其细胞毒作用
Shin Foong Ngiow,Sasikanth Manne,Yinghui Jane Huang et al.
Shin Foong Ngiow et al.
Exhausted CD8 T (Tex) cells in chronic viral infection and cancer have sustained co-expression of inhibitory receptors (IRs). Tex cells can be reinvigorated by blocking IRs, such as PD-1, but synergistic reinvigoration and enhanced disease ...
Guidelines for minimal information on cellular senescence experimentation in vivo [0.03%]
有关体内细胞衰老实验的最少信息标准指南
Mikolaj Ogrodnik,Juan Carlos Acosta,Peter D Adams et al.
Mikolaj Ogrodnik et al.
Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue repair to chronic disease. The development ...
Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry [0.03%]
窥探秘密：原子水平解析HKU1病毒进入宿主细胞过程中sialoglycan与TMPRSS2的相互作用机制
Ruth J Parsons,Priyamvada Acharya
Ruth J Parsons
The pre-fusion coronavirus HKU1 spike binds host sialoglycans and proteinaceous receptor TMPRSS2 for cell entry. In this issue of Cell, three papers by Fernández et al., McCallum et al., and Wang et al. provide structural information on HK...
Courtney T Kureshi,Michael Dougan,Stephanie K Dougan
Courtney T Kureshi
LAG-3 is the third immune checkpoint pathway successfully targeted for cancer therapy. Although ineffective as a monotherapy, combination of LAG-3 and PD-1 blockade improves survival from advanced melanoma. In this issue of Cell, two studie...
Gonazalo Moratorio,Sannula Kesavardhana,Seema S Lakdawala et al.
Gonazalo Moratorio et al.
H5N1 is an avian influenza virus that causes respiratory disease in birds and several land and sea mammals. The recent outbreak in the United States, including infection of dairy workers, has increased the concern around potential transmiss...
The FXR1 network acts as a signaling scaffold for actomyosin remodeling [0.03%]
FXR1网络作为肌动蛋白肌球蛋白重塑的信号支架作用
Xiuzhen Chen,Mervin M Fansler,Urška Janjoš et al.
Xiuzhen Chen et al.
It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we report the fragile X-related protein 1 (FXR1) network, an mRNA-protein (mRNP) network present throughout the cytoplasm, formed by FXR1-mediated pack...
Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay [0.03%]
中性粒细胞捕获和内吞噬作用及肥大细胞介导的炎性信号传递过程
Michael Mihlan,Stefanie Wissmann,Alina Gavrilov et al.
Michael Mihlan et al.
Neutrophils are sentinel immune cells with essential roles for antimicrobial defense. Most of our knowledge on neutrophil tissue navigation derived from wounding and infection models, whereas allergic conditions remained largely neglected. ...
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance [0.03%]
一种解旋酶相关的组蛋白H3-H4分子伴侣，它能够用于表观遗传学的传承
Juntao Yu,Yujie Zhang,Yimeng Fang et al.
Juntao Yu et al.
Faithful transfer of parental histones to newly replicated daughter DNA strands is critical for inheritance of epigenetic states. Although replication proteins that facilitate parental histone transfer have been identified, how intact histo...