Xingcong Jiang,Eleftherios Dimitriou,Veit Grabe et al.
Xingcong Jiang et al.
The representation of odors in the locust antennal lobe with its >2,000 glomeruli has long remained a perplexing puzzle. We employed the CRISPR-Cas9 system to generate transgenic locusts expressing the genetically encoded calcium indicator ...
The genomic and cellular basis of biosynthetic innovation in rove beetles [0.03%]
小型步甲昆虫次生代谢产物生物合成创新的基因组和细胞基础
Sheila A Kitchen,Thomas H Naragon,Adrian Brückner et al.
Sheila A Kitchen et al.
How evolution at the cellular level potentiates macroevolutionary change is central to understanding biological diversification. The >66,000 rove beetle species (Staphylinidae) form the largest metazoan family. Combining genomic and cell ty...
A metabolomics pipeline highlights microbial metabolism in bloodstream infections [0.03%]
一种代谢组学流程可揭示血流感染中的微生物代谢作用
Jared R Mayers,Jack Varon,Ruixuan R Zhou et al.
Jared R Mayers et al.
The growth of antimicrobial resistance (AMR) highlights an urgent need to identify bacterial pathogenic functions that may be targets for clinical intervention. Although severe infections profoundly alter host metabolism, prior studies have...
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis [0.03%]
STING介导的神经元炎症应激反应与多发性硬化症发病相关
Marcel S Woo,Christina Mayer,Lars Binkle-Ladisch et al.
Marcel S Woo et al.
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting the neuronal inflammatory stress response, we discovered that neurons in MS and its mouse m...
NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation [0.03%]
NLRC5感应NAD+缺乏，形成PANoptosome并驱动PANoptosis和炎症反应
Balamurugan Sundaram,Nagakannan Pandian,Hee Jin Kim et al.
Balamurugan Sundaram et al.
NLRs constitute a large, highly conserved family of cytosolic pattern recognition receptors that are central to health and disease, making them key therapeutic targets. NLRC5 is an enigmatic NLR with mutations associated with inflammatory a...
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms [0.03%]
人兽共患病原体交互图谱揭示致病机制
Thomas M Hart,Nicole D Sonnert,Xiaotian Tang et al.
Thomas M Hart et al.
Vector-borne diseases are a leading cause of death worldwide and pose a substantial unmet medical need. Pathogens binding to host extracellular proteins (the "exoproteome") represents a crucial interface in the etiology of vector-borne dise...
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors [0.03%]
纠正树突状细胞的年龄相关缺陷可使CD4+T细胞根除肿瘤
Dania Zhivaki,Stephanie N Kennedy,Josh Park et al.
Dania Zhivaki et al.
Defective host defenses later in life are associated with changes in immune cell activities, suggesting that age-specific considerations are needed in immunotherapy approaches. In this study, we found that PD-1 and CTLA4-based cancer immuno...
A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis [0.03%]
一种假常染色体糖基化障碍促使对多利醇生物合成进行修正
Matthew P Wilson,Takfarinas Kentache,Charlotte R Althoff et al.
Matthew P Wilson et al.
Published Erratum
Cell. 2024 Jul 11;187(14):3784. DOI:10.1016/j.cell.2024.06.004 2024
Retraction Notice to: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers [0.03%]
撤稿：由刺激特异性NPAS4异二聚体对神经去极化进行基因组解码的通知
G Stefano Brigidi,Michael G B Hayes,Nathaniel P Delos Santos et al.
G Stefano Brigidi et al.
Retraction of Publication
Cell. 2024 Jul 11;187(14):3785. DOI:10.1016/j.cell.2024.06.008 2024
Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa [0.03%]
单分子成像揭示了多细胞动物双向复制起始的机制
Riki Terui,Scott E Berger,Larissa A Sambel et al.
Riki Terui et al.
Metazoan genomes are copied bidirectionally from thousands of replication origins. Replication initiation entails the assembly and activation of two CMG helicases (Cdc45⋅Mcm2-7⋅GINS) at each origin. This requires several replication firin...