Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity [0.03%]
凝聚界面力重新定位DNA基因座并探测染色质粘弹性
Amy R Strom,Yoonji Kim,Hongbo Zhao et al.
Amy R Strom et al.
Biomolecular condensates assemble in living cells through phase separation and related phase transitions. An underappreciated feature of these dynamic molecular assemblies is that they form interfaces with other cellular structures, includi...
Dynamic regulation of tissue fluidity controls skin repair during wound healing [0.03%]
伤口愈合过程中动态调节组织流动性控制皮肤修复
Rahul M Sarate,Joel Hochstetter,Manon Valet et al.
Rahul M Sarate et al.
During wound healing, different pools of stem cells (SCs) contribute to skin repair. However, how SCs become activated and drive the tissue remodeling essential for skin repair is still poorly understood. Here, by developing a mouse model a...
Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment [0.03%]
阴道乳杆菌脂肪酸反应机制揭示了细菌性阴道病治疗的代谢物靶向策略
Meilin Zhu,Matthew W Frank,Christopher D Radka et al.
Meilin Zhu et al.
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus-deficient vaginal microbiota, is associated with adverse health outcomes. BV often recurs after standard antibiotic therapy in part because antibiotics promote micro...
Mining human microbiomes reveals an untapped source of peptide antibiotics [0.03%]
挖掘人类微生物组发现了一种未被开发的肽类抗生素来源
Marcelo D T Torres,Erin F Brooks,Angela Cesaro et al.
Marcelo D T Torres et al.
Drug-resistant bacteria are outpacing traditional antibiotic discovery efforts. Here, we computationally screened 444,054 previously reported putative small protein families from 1,773 human metagenomes for antimicrobial properties, identif...
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development [0.03%]
施万细胞分泌的PGE2在发育过程中促进感觉神经元兴奋性
Husniye Kantarci,Pablo D Elvira,Arun P Thottumkara et al.
Husniye Kantarci et al.
Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development and whether excitability is an intrinsic property of neurons remain unclear. Here...
High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases [0.03%]
油酰-ACP水解酶高表达导致危及生命的呼吸系统病毒感染
Xiaoxiao Jia,Jeremy Chase Crawford,Deborah Gebregzabher et al.
Xiaoxiao Jia et al.
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal dise...
Daan J Kloosterman,Johanna Erbani,Menno Boon et al.
Daan J Kloosterman et al.
Tumors growing in metabolically challenged environments, such as glioblastoma in the brain, are particularly reliant on crosstalk with their tumor microenvironment (TME) to satisfy their high energetic needs. To study the intricacies of thi...
Digvijay Singh,Neelesh Soni,Joshua Hutchings et al.
Digvijay Singh et al.
The nuclear pore complex (NPC) is the sole mediator of nucleocytoplasmic transport. Despite great advances in understanding its conserved core architecture, the peripheral regions can exhibit considerable variation within and between specie...
The need to diversify genomic studies: Insights from Andean highlanders and Amazonians [0.03%]
基因组研究多样化的必要性：安第斯高原人和亚马逊人的视角
Isabela Alvim,Carolina Silva-Carvalho,Marla Mendes de Aquino et al.
Isabela Alvim et al.
More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response ...
Stress-sensitive neural circuits change the gut microbiome via duodenal glands [0.03%]
应激敏感神经环路通过十二指肠腺体改变肠道微生物群
Hao Chang,Matthew H Perkins,Leonardo S Novaes et al.
Hao Chang et al.
Negative psychological states impact immunity by altering the gut microbiome. However, the relationship between brain states and microbiome composition remains unclear. We show that Brunner's glands in the duodenum couple stress-sensitive b...