Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas [0.03%]
具有扰动细胞和组织图谱的因果细胞和组织生物学基础模型研究
Jennifer E Rood,Anna Hupalowska,Aviv Regev
Jennifer E Rood
Comprehensively charting the biologically causal circuits that govern the phenotypic space of human cells has often been viewed as an insurmountable challenge. However, in the last decade, a suite of interleaved experimental and computation...
Longqi Liu,Ao Chen,Yuxiang Li et al.
Longqi Liu et al.
The completion of the Human Genome Project has provided a foundational blueprint for understanding human life. Nonetheless, understanding the intricate mechanisms through which our genetic blueprint is involved in disease or orchestrates de...
Chris Xu,Maiken Nedergaard,Deborah J Fowell et al.
Chris Xu et al.
Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical imaging, particularly for studying biological tissues deep within living organisms. MPFM overcomes the strong scattering of light in heterogeneous tissue by util...
Dhrithi Deshpande,Karishma Chhugani,Tejasvene Ramesh et al.
Dhrithi Deshpande et al.
Computational data-centric research techniques play a prevalent and multi-disciplinary role in life science research. In the past, scientists in wet labs generated the data, and computational researchers focused on creating tools for the an...
In vitro human cell-based models: What can they do and what are their limitations? [0.03%]
体外人类细胞模型能做什么和不能做什么？
Matthias P Lutolf,Milica Radisic,Jeffrey Beekman et al.
Matthias P Lutolf et al.
It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations?...
Yvonne Y Chen,Charles L Evavold,Matthias Mann et al.
Yvonne Y Chen et al.
We asked researchers from a range of disciplines across biology, engineering, and medicine to describe a current technological need. The goal is to provide a sample of the various technological gaps that exist and inspire future research pr...
Cell editorial team
Cell editorial team
Xiao-Yuan Yang,Zhangfei Shen,Chen Wang et al.
Xiao-Yuan Yang et al.
Horizontal gene transfer is a key driver of bacterial evolution, but it also presents severe risks to bacteria by introducing invasive mobile genetic elements. To counter these threats, bacteria have developed various defense systems, inclu...
The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA [0.03%]
含糖RNA中的glycoRNA glycosite(acp3U)是一个修饰的RNA基序
Yixuan Xie,Peiyuan Chai,Nicholas A Till et al.
Yixuan Xie et al.
GlycoRNA consists of RNAs modified with secretory N-glycans that are presented on the cell surface. Although previous work supported a covalent linkage between RNA and glycans, the direct chemical nature of the RNA-glycan connection was not...
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma [0.03%]
性染色体易位肾细胞癌的遗传基础的性别差异
Mingkee Achom,Ananthan Sadagopan,Chunyang Bao et al.
Mingkee Achom et al.
Xp11 translocation renal cell carcinoma (tRCC) is a rare, female-predominant cancer driven by a fusion between the transcription factor binding to IGHM enhancer 3 (TFE3) gene on chromosome Xp11.2 and a partner gene on either chromosome X (c...