Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance [0.03%]
病毒DNA聚合酶结构揭示了抗病毒药物耐药性的机制
Sundaresh Shankar,Junhua Pan,Pan Yang et al.
Sundaresh Shankar et al.
DNA polymerases are important drug targets, and many structural studies have captured them in distinct conformations. However, a detailed understanding of the impact of polymerase conformational dynamics on drug resistance is lacking. We de...
Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals [0.03%]
镶嵌沙贝科病毒纳米颗粒可诱导预接种动物产生交叉反应性免疫响应
Alexander A Cohen,Jennifer R Keeffe,Ariën Schiepers et al.
Alexander A Cohen et al.
Immunization with mosaic-8b (nanoparticles presenting 8 SARS-like betacoronavirus [sarbecovirus] receptor-binding domains [RBDs]) elicits more broadly cross-reactive antibodies than homotypic SARS-CoV-2 RBD-only nanoparticles and protects a...
Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae [0.03%]
绿藻叶绿体Ycf2-FtsHi蛋白输入机的保守性和专一性
Ke Liang,Xiechao Zhan,Yuxin Li et al.
Ke Liang et al.
The protein import motor in chloroplasts plays a pivotal role in their biogenesis and homeostasis by driving the translocation of preproteins into chloroplasts. While the Ycf2-FtsHi complex serves as the import motor in land plants, its evo...
Opposing GPCR signaling programs protein intake setpoint in Drosophila [0.03%]
GPCR信号传导程序反对果蝇蛋白质摄入设定点
Guangyan Wu,Tianji Ma,Clare E Hancock et al.
Guangyan Wu et al.
Animals defend a target level for their fundamental needs, including food, water, and sleep. Deviation from the target range, or "setpoint," triggers motivated behaviors to eliminate that difference. Whether and how the setpoint itself is e...
Animal and bacterial viruses share conserved mechanisms of immune evasion [0.03%]
动物病毒和细菌病毒具有免疫逃避的保守机制
Samuel J Hobbs,Jason Nomburg,Jennifer A Doudna et al.
Samuel J Hobbs et al.
Animal and bacterial cells sense and defend against viral infections using evolutionarily conserved antiviral signaling pathways. Here, we show that viruses overcome host signaling using mechanisms of immune evasion that are directly shared...
A line attractor encoding a persistent internal state requires neuropeptide signaling [0.03%]
一种行吸引子编码持久内部状态需要神经肽信号转导
George Mountoufaris,Aditya Nair,Bin Yang et al.
George Mountoufaris et al.
Internal states drive survival behaviors, but their neural implementation is poorly understood. Recently, we identified a line attractor in the ventromedial hypothalamus (VMH) that represents a state of aggressiveness. Line attractors can b...
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance [0.03%]
范可尼贫血信号通路诱导染色体爆炸及药物抗拒的癌基因双微体形成
Justin L Engel,Xiao Zhang,Mingming Wu et al.
Justin L Engel et al.
Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks and replication defects throughout interphase, how chromosomes undergo s...
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration [0.03%]
甲状腺激素重塑皮层以协调全身代谢和探索行为
Daniel R Hochbaum,Lauren Hulshof,Amanda Urke et al.
Daniel R Hochbaum et al.
Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here, we...
Memory B cell fitness and anergy has significant links to cancer lethality [0.03%]
记忆B细胞的适应性和无能与癌症致命性有显著联系
Daniel Hollern
Daniel Hollern
Two recent studies reveal that the extent of fitness or anergy in tumor-associated memory B cells is vital to anti-tumor immune response, cancer patient survival, and response to immune therapy. The impact of these seminal findings demonstr...
OLAH connects fatty acid metabolism to the severity of respiratory viral disease [0.03%]
OLAH连接脂肪酸代谢与呼吸道病毒感染严重性
Rohan Palanki,Hannah Yamagata,Michael J Mitchell
Rohan Palanki
Respiratory virus infections may cause profound respiratory illness, yet the factors that underlie disease severity are not well understood. In this issue of Cell, Jia, Crawford, et al.1 identify the role of oleoyl-ACP-hydrolase (OLAH) in m...