Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles [0.03%]
利用蛋白脂质载体安全有效地进行体内DNA和RNA输送
Douglas W Brown,Ping Wee,Prakash Bhandari et al.
Douglas W Brown et al.
Genetic medicines show promise for treating various diseases, yet clinical success has been limited by tolerability, scalability, and immunogenicity issues of current delivery platforms. To overcome these, we developed a proteolipid vehicle...
Yifan Dai,Zhengqing Zhou,Wen Yu et al.
Yifan Dai et al.
Control of the electrochemical environment in living cells is typically attributed to ion channels. Here, we show that the formation of biomolecular condensates can modulate the electrochemical environment in bacterial cells, which affects ...
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket [0.03%]
通过保守的隐蔽口袋靶向Ras、Rho和Rab家族GTP酶
Johannes Morstein,Victoria Bowcut,Micah Fernando et al.
Johannes Morstein et al.
The family of Ras-like GTPases consists of over 150 different members, regulated by an even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs) that comprise cellular switch networks that govern cell motil...
Haowu Jiang,Huan Cui,Mengyu Chen et al.
Haowu Jiang et al.
Sneezing and coughing are primary symptoms of many respiratory viral infections and allergies. It is generally assumed that sneezing and coughing involve common sensory receptors and molecular neurotransmission mechanisms. Here, we show tha...
Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy [0.03%]
衰老黑色素瘤肿瘤微环境的性别差异影响侵袭和靶向治疗抗性
Yash Chhabra,Mitchell E Fane,Sneha Pramod et al.
Yash Chhabra et al.
There is documented sex disparity in cutaneous melanoma incidence and mortality, increasing disproportionately with age and in the male sex. However, the underlying mechanisms remain unclear. While biological sex differences and inherent im...
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity [0.03%]
小分子GSDMD激动剂可激活肿瘤抗肿瘤免疫且无毒性效应
Pietro Fontana,Gang Du,Ying Zhang et al.
Pietro Fontana et al.
Gasdermin-mediated inflammatory cell death (pyroptosis) can activate protective immunity in immunologically cold tumors. Here, we performed a high-throughput screen for compounds that could activate gasdermin D (GSDMD), which is expressed w...
TGF-β and RAS jointly unmask primed enhancers to drive metastasis [0.03%]
TGF-β和RAS联合激活预备增强子以驱动转移性癌的发展
Jun Ho Lee,Francisco J Sánchez-Rivera,Lan He et al.
Jun Ho Lee et al.
Epithelial-to-mesenchymal transitions (EMTs) and extracellular matrix (ECM) remodeling are distinct yet important processes during carcinoma invasion and metastasis. Transforming growth factor β (TGF-β) and RAS, signaling through SMAD and...
Hellmut G Augustin,Gou Young Koh
Hellmut G Augustin
The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endo...
Carlise Sorenson,Katarzyna P Adamala
Carlise Sorenson
Building biological computers is one of the most intensively pursued goals of modern synthetic biology. The new TriLoS tristate-based logic synthesis platform, published in this issue of Cell, offers a long-awaited solution to scale up the ...
Tian-Li Wang,Ie-Ming Shih
Tian-Li Wang
Homologous-recombination deficiency in DNA repair characterizes a unique group of cancers that are vulnerable to PARP inhibitors and cytotoxic chemotherapy. In this issue of Cell, Luo et al., demonstrated that this genetic attribute in canc...