Sarah E O&#x;Connor
Sarah E O&#x;Connor
Dolichol is a lipid that is involved in protein glycosylation, a process that is essential for all eukaryotic life. In this issue of Cell, Wilson and coworkers1 report how a rare human genetic disorder led to the discovery of dolichol biosy...
Advancing accessible science for low-vision and diverse-needs communities [0.03%]
推进低视力及各类特殊需求群体的无障碍科学教育与普及
Erica Tandori,Jamie Rossjohn
Erica Tandori
Science can often be inaccessible for people with disabilities, including those with low vision or blindness. Below, we hear from Jamie Rossjohn and Erica Tandori regarding the insights and experiences into the establishment of an internshi...
Michael J Johnston,John J Y Lee,Bo Hu et al.
Michael J Johnston et al.
Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed...
A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence [0.03%]
一种小核仁RNA在核糖体生物发生和衰老中发挥非典范作用
Yujing Cheng,Siwen Wang,He Zhang et al.
Yujing Cheng et al.
Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses, including aberrant oncogene activation, telomere shortening, and DNA damage. Through a genome-wide screen, we discovered a conserved small nucleo...
All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons [0.03%]
具有理性工程R2反向转座子的哺乳动物细胞全RNA介导的目标基因整合
Yangcan Chen,Shengqiu Luo,Yanping Hu et al.
Yangcan Chen et al.
All-RNA-mediated targeted gene integration methods, rendering reduced immunogenicity, effective deliverability with non-viral vehicles, and a low risk of random mutagenesis, are urgently needed for next-generation gene addition technologies...
Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries [0.03%]
来自32个国家的56,989名个体中的肠胞子虫与更健康的饮食和更有利的心脏代谢结局有关
Elisa Piperni,Long H Nguyen,Paolo Manghi et al.
Elisa Piperni et al.
Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-euk...
Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma [0.03%]
特异性的人类神经血管生态位早期菱形唇Protogenin⁺干/祖细胞启动并维持第3组髓母细胞瘤发生发展
Abhirami Visvanathan,Olivier Saulnier,Chuan Chen et al.
Abhirami Visvanathan et al.
We identify a population of Protogenin-positive (PRTG+ve) MYChigh NESTINlow stem cells in the four-week-old human embryonic hindbrain that subsequently localizes to the ventricular zone of the rhombic lip (RLVZ). Oncogenic transformation of...
Neoadjuvant PARPi or chemotherapy in ovarian cancer informs targeting effector Treg cells for homologous-recombination-deficient tumors [0.03%]
卵巢癌的新辅助PARP抑制剂或化疗指导针对同源重组缺陷肿瘤效应调节性T细胞的治疗
Yikai Luo,Yu Xia,Dan Liu et al.
Yikai Luo et al.
Homologous recombination deficiency (HRD) is prevalent in cancer, sensitizing tumor cells to poly (ADP-ribose) polymerase (PARP) inhibition. However, the impact of HRD and related therapies on the tumor microenvironment (TME) remains elusiv...
Jiali Yu,Yijian Yan,Shasha Li et al.
Jiali Yu et al.
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human cancer types and the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune tolera...
TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry [0.03%]
TMPRSS2和糖蛋白受体协同促进冠状病毒的入侵
Haofeng Wang,Xiaoce Liu,Xiang Zhang et al.
Haofeng Wang et al.
The entry of coronaviruses is initiated by spike recognition of host cellular receptors, involving proteinaceous and/or glycan receptors. Recently, TMPRSS2 was identified as the proteinaceous receptor for HCoV-HKU1 alongside sialoglycan as ...