Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography [0.03%]
低温 cryo-电子断层扫描揭示细胞内埃博拉病毒核糖核蛋白装配体结构
Reika Watanabe,Dawid Zyla,Diptiben Parekh et al.
Reika Watanabe et al.
Filoviruses, including the Ebola and Marburg viruses, cause hemorrhagic fevers with up to 90% lethality. The viral nucleocapsid is assembled by polymerization of the nucleoprotein (NP) along the viral genome, together with the viral protein...
Mingliang Jin,Robert I Seed,Guoqing Cai et al.
Mingliang Jin et al.
TGF-β, essential for development and immunity, is expressed as a latent complex (L-TGF-β) non-covalently associated with its prodomain and presented on immune cell surfaces by covalent association with GARP. Binding to integrin αvβ8 act...
Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ [0.03%]
哺乳动物器官的长期三维细胞间动态的中规模成像
Yuanlong Zhang,Mingrui Wang,Qiyu Zhu et al.
Yuanlong Zhang et al.
A comprehensive understanding of physio-pathological processes necessitates non-invasive intravital three-dimensional (3D) imaging over varying spatial and temporal scales. However, huge data throughput, optical heterogeneity, surface irreg...
Neoself-antigens are the primary target for autoreactive T cells in human lupus [0.03%]
新自身抗原是人类狼疮自身反应性T细胞的主要靶点
Shunsuke Mori,Masako Kohyama,Yoshiaki Yasumizu et al.
Shunsuke Mori et al.
Major histocompatibility complex class II (MHC-II) is the most significant genetic risk factor for systemic lupus erythematosus (SLE), but the nature of the self-antigens that trigger autoimmunity remains unclear. Unusual self-antigens, ter...
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy [0.03%]
细胞间纳米管介导的线粒体转移增强T细胞代谢活性和抗肿瘤功效
Jeremy G Baldwin,Christoph Heuser-Loy,Tanmoy Saha et al.
Jeremy G Baldwin et al.
Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming these limit...
A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes [0.03%]
发育梯度揭示了单子叶球根植物中真核毒素的生物合成途径
Niraj Mehta,Yifan Meng,Richard Zare et al.
Niraj Mehta et al.
Numerous eukaryotic toxins that accumulate in geophytic plants are valuable in the clinic, yet their biosynthetic pathways have remained elusive. A notable example is the >150 Amaryllidaceae alkaloids (AmAs), including galantamine, an FDA-a...
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function [0.03%]
利用模版聚合来降解致病性tau聚集体并改善运动功能
Lauren V C Miller,Guido Papa,Marina Vaysburd et al.
Lauren V C Miller et al.
Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and removing aggregates, but not the functional protein, is a considerable therapeutic challenge. Here, we describe a therapeutic strategy called "RING-Bait," ...
Yuanhan Yang,Xiaoyong Lu,Ning Liu et al.
Yuanhan Yang et al.
In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histolog...
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival [0.03%]
TEX264通过促进DNA修复和细胞存活来驱动DNA损伤的选择性自噬
Pauline Lascaux,Gwendoline Hoslett,Sara Tribble et al.
Pauline Lascaux et al.
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of DNA lesions. We discovered that lysosomes proce...
Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics [0.03%]
单细胞基因组学揭示的痴呆共患病和特异性通路
Jessica E Rexach,Yuyan Cheng,Lawrence Chen et al.
Jessica E Rexach et al.
The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNA-seq and ATAC-seq in Alzheimer's disease (AD), frontotempo...