Jiaying Huang,Qiupeng Lin,Hongyuan Fei et al.
Jiaying Huang et al.
Published Erratum
Cell. 2024 Aug 8;187(16):4426-4428. DOI:10.1016/j.cell.2024.07.003 2024
From periphery to center stage: 50 years of advancements in innate immunity [0.03%]
从边缘到舞台中央：先天免疫五十年进展
Susan Carpenter,Luke A J O&#x;Neill
Susan Carpenter
Published Erratum
Cell. 2024 Aug 8;187(16):4429-4430. DOI:10.1016/j.cell.2024.07.010 2024
Integrated cryoEM structure of a spumaretrovirus reveals cross-kingdom evolutionary relationships and the molecular basis for assembly and virus entry [0.03%]
整合的冷冻电子显微镜结构揭示了泡沫病毒的跨王国进化关系及其组装和病毒感染的分子基础
Thomas Calcraft,Nicole Stanke-Scheffler,Andrea Nans et al.
Thomas Calcraft et al.
Foamy viruses (FVs) are an ancient lineage of retroviruses, with an evolutionary history spanning over 450 million years. Vector systems based on Prototype Foamy Virus (PFV) are promising candidates for gene and oncolytic therapies. Structu...
Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis [0.03%]
同种异体CD19靶向CAR-T治疗严重肌炎和系统性硬化症患者的疗效
Xiaobing Wang,Xin Wu,Binghe Tan et al.
Xiaobing Wang et al.
Allogeneic chimeric antigen receptor (CAR)-T cells hold great promise for expanding the accessibility of CAR-T therapy, whereas the risks of allograft rejection have hampered its application. Here, we genetically engineered healthy-donor-de...
Clinical Trial
Cell. 2024 Sep 5;187(18):4890-4904.e9. DOI:10.1016/j.cell.2024.06.027 2024
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins [0.03%]
具有酸性聚簇结构域的cargo蛋白受体-WDR11复合物
Huaqing Deng,Guowen Jia,Ping Li et al.
Huaqing Deng et al.
Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells. Cargo recognition primarily occurs through coats and the associated...
Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching [0.03%]
唐尤素信号在突触配对中的分子和细胞机制研究
Chuanyun Xu,Zhuoran Li,Cheng Lyu et al.
Chuanyun Xu et al.
In developing brains, axons exhibit remarkable precision in selecting synaptic partners among many non-partner cells. Evolutionarily conserved teneurins are transmembrane proteins that instruct synaptic partner matching. However, how intrac...
Jiafeng Huang,Xiaolin Zhang,Xiaohua Nie et al.
Jiafeng Huang et al.
Latent membrane protein 1 (LMP1) is the primary oncoprotein of Epstein-Barr virus (EBV) and plays versatile roles in the EBV life cycle and pathogenesis. Despite decades of extensive research, the molecular basis for LMP1 folding, assembly,...
Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample [0.03%]
十万年前猛犸象皮肤样本中三维基因组结构的持久性
Marcela Sandoval-Velasco,Olga Dudchenko,Juan Antonio Rodríguez et al.
Marcela Sandoval-Velasco et al.
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus primigenius) that ...
Mari Kamiya,Hannah Carter,Milena S Espindola et al.
Mari Kamiya et al.
Fibrotic interstitial lung diseases (fILDs) have poor survival rates and lack effective therapies. Despite evidence for immune mechanisms in lung fibrosis, immunotherapies have been unsuccessful for major types of fILD. Here, we review immu...
Timing is everything: How plants optimize reproduction in a variable environment [0.03%]
时机很重要：植物如何在多变的环境中优化繁殖
David L Des Marais
David L Des Marais
Organisms experience a constantly changing environment and must adjust their development to maximize fitness. These "life histories" are fantastically diverse and have fascinated biologists for decades. Recent work published in Cell reveals...