Scientists' call to action: Microbes, planetary health, and the Sustainable Development Goals [0.03%]
科学家的呼吁：微生物、行星健康与可持续发展目标
Thomas W Crowther,Rino Rappuoli,Cinzia Corinaldesi et al.
Thomas W Crowther et al.
Microorganisms, including bacteria, archaea, viruses, fungi, and protists, are essential to life on Earth and the functioning of the biosphere. Here, we discuss the key roles of microorganisms in achieving the United Nations Sustainable Dev...
Transforming vaccinology [0.03%]
疫苗学的变革
Rino Rappuoli,Galit Alter,Bali Pulendran
Rino Rappuoli
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global consciousness, emphasizing the vital role of vaccines as transformative public health tools. The impact of vaccines was recently acknowledged by the awar...
Modern microbiology: Embracing complexity through integration across scales [0.03%]
现代微生物学：通过多尺度整合来迎接复杂性挑战
A Murat Eren,Jillian F Banfield
A Murat Eren
Microbes were the only form of life on Earth for most of its history, and they still account for the vast majority of life's diversity. They convert rocks to soil, produce much of the oxygen we breathe, remediate our sewage, and sustain agr...
Gerald Mboowa,Sofonias K Tessema,Alan Christoffels et al.
Gerald Mboowa et al.
Rapid expansion of pathogen sequencing capacity in Africa has led to a paradigm shift from relying on others to locally generating genomic data and sharing it with the global community. However, several barriers remain to be unlocked for ti...
Edward C Holmes,Florian Krammer,Felicia D Goodrum
Edward C Holmes
Virology has made enormous advances in the last 50 years but has never faced such scrutiny as it does today. Herein, we outline some of the major advances made in virology during this period, particularly in light of the COVID-19 pandemic, ...
Focus on fungi [0.03%]
聚焦真菌
Iliyan D Iliev,Gordon D Brown,Petra Bacher et al.
Iliyan D Iliev et al.
Fungi play critical roles in the homeostasis of ecosystems globally and have emerged as significant causes of an expanding repertoire of devastating diseases in plants, animals, and humans. In this Commentary, we highlight the importance of...
A microbial future [0.03%]
微生物的未来
Cell editorial team
Cell editorial team
Life as we know it began with microbes. Microbes sustain life on Earth, and every now and then, a microbe emerges that threatens the survival of an entire species. The dangers and benefits of microbial life are both enormous, as is their po...
High-resolution functional mapping of RAD51C by saturation genome editing [0.03%]
饱和基因组编辑的RAD51C高分辨率功能图谱绘制
Rebeca Olvera-León,Fang Zhang,Victoria Offord et al.
Rebeca Olvera-León et al.
Pathogenic variants in RAD51C confer an elevated risk of breast and ovarian cancer, while individuals homozygous for specific RAD51C alleles may develop Fanconi anemia. Using saturation genome editing (SGE), we functionally assess 9,188 uni...
In vivo DNA replication dynamics unveil aging-dependent replication stress [0.03%]
体内DNA复制动力学揭示了与衰老相关的复制压力
Giacomo G Rossetti,Noëlle Dommann,Angeliki Karamichali et al.
Giacomo G Rossetti et al.
The genome duplication program is affected by multiple factors in vivo, including developmental cues, genotoxic stress, and aging. Here, we monitored DNA replication initiation dynamics in regenerating livers of young and old mice after par...
Helen H Yang,Bella E Brezovec,Laia Serratosa Capdevila et al.
Helen H Yang et al.
Locomotion involves rhythmic limb movement patterns that originate in circuits outside the brain. Purposeful locomotion requires descending commands from the brain, but we do not understand how these commands are structured. Here, we invest...