Heather Christofk,Christian Metallo,Guanghui Liu et al.
Heather Christofk et al.
Recent advancements in technology, especially the emergence of single-cell technologies, genomic sequencing, metabolomics, and artificial intelligence, have enabled us to understand the distinct metabolic changes in different cell types, ti...
E Dale Abel,Anna L Gloyn,Carmella Evans-Molina et al.
E Dale Abel et al.
Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads to complications that reduce quality of life and increase mortality. Diabetes pathophysiology includes dysfunction of beta cells, adipose tissue, skele...
Cell editorial team
Cell editorial team
This 50th Anniversary Focus on Metabolism highlights several foundational and current themes of interest in metabolism research. Copyright © 2024 Elsevi...
Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes [0.03%]
泛癌种单细胞解析揭示了不同表型的B细胞亚群
Yu Yang,Xueyan Chen,Jieying Pan et al.
Yu Yang et al.
Characterizing the compositional and phenotypic characteristics of tumor-infiltrating B cells (TIBs) is important for advancing our understanding of their role in cancer development. Here, we establish a comprehensive resource of human B ce...
Eftychios Frangedakis,Nataliya E Yelina,Kumari Billakurthi et al.
Eftychios Frangedakis et al.
Chloroplast biogenesis is dependent on master regulators from the GOLDEN2-LIKE (GLK) family of transcription factors. However, glk mutants contain residual chlorophyll, indicating that other proteins must be involved. Here, we identify MYB-...
Innate immune memory after brain injury drives inflammatory cardiac dysfunction [0.03%]
中枢神经系统损伤后的先天免疫记忆诱导心脏炎症损伤
Alba Simats,Sijia Zhang,Denise Messerer et al.
Alba Simats et al.
The medical burden of stroke extends beyond the brain injury itself and is largely determined by chronic comorbidities that develop secondarily. We hypothesized that these comorbidities might share a common immunological cause, yet chronic ...
Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit [0.03%]
小脑恐惧回路中的肽类神经递质作为初级神经递质的 presynaptic 传感器和抑制器
Dong-Il Kim,Sekun Park,Seahyung Park et al.
Dong-Il Kim et al.
Neurons produce and release neuropeptides to communicate with one another. Despite their importance in brain function, circuit-based mechanisms of peptidergic transmission are poorly understood, primarily due to the lack of tools for monito...
Jiaying Huang,Qiupeng Lin,Hongyuan Fei et al.
Jiaying Huang et al.
Published Erratum
Cell. 2024 Aug 8;187(16):4426-4428. DOI:10.1016/j.cell.2024.07.003 2024
From periphery to center stage: 50 years of advancements in innate immunity [0.03%]
从边缘到舞台中央：先天免疫五十年进展
Susan Carpenter,Luke A J O&#x;Neill
Susan Carpenter
Published Erratum
Cell. 2024 Aug 8;187(16):4429-4430. DOI:10.1016/j.cell.2024.07.010 2024
Integrated cryoEM structure of a spumaretrovirus reveals cross-kingdom evolutionary relationships and the molecular basis for assembly and virus entry [0.03%]
整合的冷冻电子显微镜结构揭示了泡沫病毒的跨王国进化关系及其组装和病毒感染的分子基础
Thomas Calcraft,Nicole Stanke-Scheffler,Andrea Nans et al.
Thomas Calcraft et al.
Foamy viruses (FVs) are an ancient lineage of retroviruses, with an evolutionary history spanning over 450 million years. Vector systems based on Prototype Foamy Virus (PFV) are promising candidates for gene and oncolytic therapies. Structu...