Nothing about us without us: Sharing results with communities that provide genomic data [0.03%]
没有我们，不为我们：与提供基因组数据的社区分享成果
Sarah LeBaron von Baeyer,Rebecca M Crocker,Rindra Rakotoarivony et al.
Sarah LeBaron von Baeyer et al.
Sharing genetic and other study results with the communities who participate in research falls under benefit-sharing and capacity-building initiatives that underpin a more equitable biomedical research relationship. Yet, which results to re...
A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria [0.03%]
哺乳动物线粒体中的传递性钠梯度控制膜电位
Pablo Hernansanz-Agustín,Carmen Morales-Vidal,Enrique Calvo et al.
Pablo Hernansanz-Agustín et al.
Eukaryotic cell function and survival rely on the use of a mitochondrial H+ electrochemical gradient (Δp), which is composed of an inner mitochondrial membrane (IMM) potential (ΔΨmt) and a pH gradient (ΔpH). So far, ΔΨmt has been assu...
A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease [0.03%]
参与快动眼睡眠且在帕金森病中受损的桥延环路
Mitsuaki Kashiwagi,Goichi Beck,Mika Kanuka et al.
Mitsuaki Kashiwagi et al.
Identifying the properties of the rapid eye movement (REM) sleep circuitry and its relation to diseases has been challenging due to the neuronal heterogeneity of the brainstem. Here, we show in mice that neurons in the pontine sublaterodors...
Robert A Weinberg
Robert A Weinberg
Published Erratum
Cell. 2024 Oct 17;187(21):6123. DOI:10.1016/j.cell.2024.09.010 2024
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic [0.03%]
在新冠疫情震中追踪市场野生动物和病毒的遗传痕迹
Alexander Crits-Christoph,Joshua I Levy,Jonathan E Pekar et al.
Alexander Crits-Christoph et al.
Zoonotic spillovers of viruses have occurred through the animal trade worldwide. The start of the COVID-19 pandemic was traced epidemiologically to the Huanan Seafood Wholesale Market. Here, we analyze environmental qPCR and sequencing data...
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development [0.03%]
母乳喂养决定微生物定植程序并指导健康呼吸道发育
Liat Shenhav,Kelsey Fehr,Myrtha E Reyna et al.
Liat Shenhav et al.
Breastfeeding and microbial colonization during infancy occur within a critical time window for development, and both are thought to influence the risk of respiratory illness. However, the mechanisms underlying the protective effects of bre...
C Patrick Lusk,Megan C King
C Patrick Lusk
Nuclear pore complexes are massive protein gateways that control molecular exchange between the nucleus and cytoplasm. In this issue of Cell, Singh et al. provide the first high-resolution views of the elusive nuclear basket, which extends ...
A prokaryotic Argonaute protein recruits a helicase-nuclease to degrade invading plasmids [0.03%]
一种原核Argonaute蛋白通过招募解旋酶-核酸酶来降解入侵质粒
Dmitriy Ignatov,Vivekanandan Shanmuganathan,Emmanuelle Charpentier
Dmitriy Ignatov
DdmDE is a novel plasmid defense system that was discovered in the seventh pandemic Vibrio cholerae strain of the biotype O1 EI Tor. In this issue of Cell, Yang and coworkers reveal the mechanisms underlying the assembly and activation of t...
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s? [0.03%]
探究真核生物中的RNA引导的DNA内切酶：FanZ-样系统是CRISPR-Cas12系统的同源系统吗？
Satoshi N Omura,Osamu Nureki
Satoshi N Omura
Fanzors are recently characterized RNA-guided DNA endonucleases found in eukaryotic organisms. In this issue of Cell, Xu, Saito et al. reveal the structural diversity of Fanzors and identify key features shared with TnpB and Cas12 proteins,...
Catharine Adams,A Pedro Gonçalves,Sally Warring et al.
Catharine Adams et al.
The world of microbes is diverse, but the majority of these fascinating organisms are not as famous (or perhaps infamous) as their pathogenic counterparts. Cell highlights six scientists whose work addresses some of the most fundamental que...