I Sadaf Farooqi,Yong Xu
I Sadaf Farooqi
Obesity causes significant morbidity and mortality globally. Research in the last three decades has delivered a step-change in our understanding of the fundamental mechanisms that regulate energy homeostasis, building on foundational discov...
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5 [0.03%]
天然恶性疟原虫感染可诱发稀有但高效的针对RH5的中和抗体响应
Lawrence T Wang,Andrew J R Cooper,Brendan Farrell et al.
Lawrence T Wang et al.
Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is the most advanced blood-stage malaria vaccine candidate and is being evaluated for efficacy in endemic regions, emphasizing the need to study the underlying antibody resp...
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype [0.03%]
分析疟原虫配体RH5多样的抗原景观，鉴定出一个诱导产生强烈的疫苗抗体反应的公共克隆型抗体家族
Jordan R Barrett,Dimitra Pipini,Nathan D Wright et al.
Jordan R Barrett et al.
The highly conserved and essential Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has emerged as the leading target for vaccines against the disease-causing blood stage of malaria. However, the features of the human va...
"Boosting" tumor immunity in elderly mice by hyperactivating dendritic cells [0.03%]
通过过度激活树突细胞增强老年小鼠的肿瘤免疫能力
Jiaqi Liu,Feng Shao
Jiaqi Liu
Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells "hyperactivated" by specific adjuvants elicit TH1-skewed CD4+ T cell response...
Translating metabolic and cardiovascular research into effective treatments: What's next? [0.03%]
代谢和心血管研究向有效治疗的转化：下一步是什么？
Juleen R Zierath,Jolanda van der Velden,Ali Javaheri et al.
Juleen R Zierath et al.
The future of healthcare for cardiovascular diseases holds immense promise, not only based in new discoveries in cardiac metabolism but also in translating them to solutions for critical challenges faced by society. Here, ten scientists sha...
Metabolism in the spotlight: Dr. Giles Yeo on the impact and challenges of science communication [0.03%]
代谢备受关注： Giles Yeo博士谈科学传播的影响与挑战
Giles S H Yeo
Giles S H Yeo
In this interview with Cell, Dr. Giles Yeo shares his journey into metabolism research, his strategies for engaging audiences, and the challenges of simplifying complex concepts. He also discusses the impact of social media, the advantages ...
Digesting the complex metabolic effects of diet on the host and microbiome [0.03%]
剖析饮食对宿主和微生物组的复杂代谢影响
Rachel N Carmody,Krista Varady,Peter J Turnbaugh
Rachel N Carmody
The past 50 years of interdisciplinary research in humans and model organisms has delivered unprecedented insights into the mechanisms through which diet affects energy balance. However, translating these results to prevent and treat obesit...
Jessica T Y Yue,Ameth N Garrido,Tony K T Lam
Jessica T Y Yue
Glucagon-like peptide-1 (GLP-1) and N-methyl-D-aspartate (NMDA) receptors in the brain regulate metabolic homeostasis. In a paper published in Nature, Petersen et al. describe a bimodal molecule that conjugates a GLP-1 analog with MK-801 (N...
Christine M Kusminski,Diego Perez-Tilve,Timo D Müller et al.
Christine M Kusminski et al.
For more than a century, physicians have searched for ways to pharmacologically reduce excess body fat. The tide has finally turned with recent advances in biochemically engineered agonists for the receptor of glucagon-like peptide-1 (GLP-1...
Sarah-Maria Fendt
Sarah-Maria Fendt
If you are a scientist and you only know one thing about tumor metabolism, it's likely the Warburg effect. But who was Otto Warburg, and how did his discoveries regarding the metabolism of tumors shape our current thinking about the metabol...