Dhanur P Iyer,Heidar Heidari Khoei,Vera A van der Weijden et al.
Dhanur P Iyer et al.
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathwa...
Bronze Age cheese reveals human-Lactobacillus interactions over evolutionary history [0.03%]
铜器时代的奶酪揭示了人类与乳酸菌在进化史上的相互作用
Yichen Liu,Bo Miao,Wenying Li et al.
Yichen Liu et al.
Despite the long history of consumption of fermented dairy, little is known about how the fermented microbes were utilized and evolved over human history. Here, by retrieving ancient DNA of Bronze Age kefir cheese (∼3,500 years ago) from t...
Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient [0.03%]
腹直肌鞘下移植化学诱导多能干细胞源性胰岛治疗1型糖尿病患者
Shusen Wang,Yuanyuan Du,Boya Zhang et al.
Shusen Wang et al.
We report the 1-year results from one patient as the preliminary analysis of a first-in-human phase I clinical trial (ChiCTR2300072200) assessing the feasibility of autologous transplantation of chemically induced pluripotent stem-cell-deri...
Clinical Trial
Cell. 2024 Oct 31;187(22):6152-6164.e18. DOI:10.1016/j.cell.2024.09.004 2024
Saturation mutagenesis-reinforced functional assays for disease-related genes [0.03%]
用于疾病相关基因的饱和诱变强化功能检测方法
Kaiyue Ma,Shushu Huang,Kenneth K Ng et al.
Kaiyue Ma et al.
Interpretation of disease-causing genetic variants remains a challenge in human genetics. Current costs and complexity of deep mutational scanning methods are obstacles for achieving genome-wide resolution of variants in disease-related gen...
Michael J Peluso,Steven G Deeks
Michael J Peluso
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC) defined by medically unexplained symptoms following infection with SARS-CoV-2, is a newly recognized infection-associated chron...
Emergence of community behaviors in the gut microbiota upon drug treatment [0.03%]
药物治疗后肠道微生物群中社区行为的出现
Sarela Garcia-Santamarina,Michael Kuhn,Saravanan Devendran et al.
Sarela Garcia-Santamarina et al.
Pharmaceuticals can directly inhibit the growth of gut bacteria, but the degree to which such interactions manifest in complex community settings is an open question. Here, we compared the effects of 30 drugs on a 32-species synthetic commu...
Microbial transformation of dietary xenobiotics shapes gut microbiome composition [0.03%]
饮食异物的微生物转化塑造肠道菌群组成
Elizabeth J Culp,Nora T Nelson,Andrew A Verdegaal et al.
Elizabeth J Culp et al.
Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome interactions may contribute to variation in their health consequences. To mechanistically understand these relationships, here we map interactions b...
Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor [0.03%]
光诱导的phytochrome B重塑使phytochrome互作因子能够进行信号转导
Zhengdong Wang,Wenfeng Wang,Didi Zhao et al.
Zhengdong Wang et al.
Phytochrome B (phyB) and phytochrome-interacting factors (PIFs) constitute a well-established signaling module critical for plants adapting to ambient light. However, mechanisms underlying phyB photoactivation and PIF binding for signal tra...
Profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy [0.03%]
食蟹猴杜氏肌营养不良模型的细胞缺陷特征及其致病机制研究
Shuaiwei Ren,Xin Fu,Wenting Guo et al.
Shuaiwei Ren et al.
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by mutations in the DMD gene. Muscle fibers rely on the coordination of multiple cell types for repair and regenerative capacity. To elucidate the cellular and...
m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells [0.03%]
癌症细胞中m6A修饰的cenRNA稳定CENP A以保证着丝粒的完整性
Zihong Kang,Ruimeng Li,Chang Liu et al.
Zihong Kang et al.
m6A modification is best known for its critical role in controlling multiple post-transcriptional processes of the mRNAs. Here, we discovered elevated levels of m6A modification on centromeric RNA (cenRNA) in cancerous cells compared with n...