Megan L Fitzgerald,Alison K Cohen,Toni Wall Jaudon et al.
Megan L Fitzgerald et al.
Long COVID is a chronic and often disabling illness with long-term consequences. Although progress has been made in the clinical characterization of long COVID, no approved treatments exist and disconnects between patients and researchers t...
Conor R Walker,Xiaoting Li,Manav Chakravarthy et al.
Conor R Walker et al.
The increase in publicly available human single-cell datasets, encompassing millions of cells from many donors, has significantly enhanced our understanding of complex biological processes. However, the accessibility of these datasets raise...
The TMEM132B-GABAA receptor complex controls alcohol actions in the brain [0.03%]
TMEM132B-γ氨基丁酸受体复合物控制大脑的酒精作用
Guohao Wang,Shixiao Peng,Miriam Reyes Mendez et al.
Guohao Wang et al.
Alcohol is the most consumed and abused psychoactive drug globally, but the molecular mechanisms driving alcohol action and its associated behaviors in the brain remain enigmatic. Here, we have discovered a transmembrane protein TMEM132B th...
Diatom pyrenoids are encased in a protein shell that enables efficient CO2 fixation [0.03%]
固氮藻叶绿体内的蛋白壳可使固碳更高效
Ginga Shimakawa,Manon Demulder,Serena Flori et al.
Ginga Shimakawa et al.
Pyrenoids are subcompartments of algal chloroplasts that increase the efficiency of Rubisco-driven CO2 fixation. Diatoms fix up to 20% of global CO2, but their pyrenoids remain poorly characterized. Here, we used in vivo photo-crosslinking ...
Molecular basis of global promoter sensing and nucleosome capture by the SWR1 chromatin remodeler [0.03%]
SWR1 组蛋白置换复合体的分子基础及其识别启动子和结合核小体的机制研究
Robert K Louder,Giho Park,Ziyang Ye et al.
Robert K Louder et al.
The SWR1 chromatin remodeling complex is recruited to +1 nucleosomes downstream of transcription start sites of eukaryotic promoters, where it exchanges histone H2A for the specialized variant H2A.Z. Here, we use cryoelectron microscopy (cr...
Pervasive mislocalization of pathogenic coding variants underlying human disorders [0.03%]
导致人类疾病的致病性编码变异的普遍定位错误
Jessica Lacoste,Marzieh Haghighi,Shahan Haider et al.
Jessica Lacoste et al.
Widespread sequencing has yielded thousands of missense variants predicted or confirmed as disease causing. This creates a new bottleneck: determining the functional impact of each variant-typically a painstaking, customized process underta...
Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders [0.03%]
跨人群和患有精神病受试者大脑中的复杂结构变异的检测与分析
Bo Zhou,Joseph G Arthur,Hanmin Guo et al.
Bo Zhou et al.
Complex structural variations (cxSVs) are often overlooked in genome analyses due to detection challenges. We developed ARC-SV, a probabilistic and machine-learning-based method that enables accurate detection and reconstruction of cxSVs fr...
Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues [0.03%]
基于石蜡包埋组织的高通量空间研究RNA生物学
Zhiliang Bai,Dingyao Zhang,Yan Gao et al.
Zhiliang Bai et al.
The capability to spatially explore RNA biology in formalin-fixed paraffin-embedded (FFPE) tissues holds transformative potential for histopathology research. Here, we present pathology-compatible deterministic barcoding in tissue (Patho-DB...
CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease [0.03%]
基于细胞外液的蛋白质组学鉴定出了早老素基因突变型阿尔茨海默病患者早期阶段的大脑变化
Yuanyuan Shen,Jigyasha Timsina,Gyujin Heo et al.
Yuanyuan Shen et al.
In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF proteins in 286 m...
Genomic surveillance as a scalable framework for precision phage therapy against antibiotic-resistant pathogens [0.03%]
基于基因组监测的大规模精准噬菌体抗菌疗法框架
Mihály Koncz,Tamás Stirling,Hiba Hadj Mehdi et al.
Mihály Koncz et al.
Phage therapy is gaining increasing interest in the fight against critically antibiotic-resistant nosocomial pathogens. However, the narrow host range of bacteriophages hampers the development of broadly effective phage therapeutics and dem...