Xiao-Yuan Yang,Zhangfei Shen,Chen Wang et al.
Xiao-Yuan Yang et al.
Horizontal gene transfer is a key driver of bacterial evolution, but it also presents severe risks to bacteria by introducing invasive mobile genetic elements. To counter these threats, bacteria have developed various defense systems, inclu...
The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA [0.03%]
含糖RNA中的glycoRNA glycosite(acp3U)是一个修饰的RNA基序
Yixuan Xie,Peiyuan Chai,Nicholas A Till et al.
Yixuan Xie et al.
GlycoRNA consists of RNAs modified with secretory N-glycans that are presented on the cell surface. Although previous work supported a covalent linkage between RNA and glycans, the direct chemical nature of the RNA-glycan connection was not...
A genetic basis for sex differences in Xp11 translocation renal cell carcinoma [0.03%]
性染色体易位肾细胞癌的遗传基础的性别差异
Mingkee Achom,Ananthan Sadagopan,Chunyang Bao et al.
Mingkee Achom et al.
Xp11 translocation renal cell carcinoma (tRCC) is a rare, female-predominant cancer driven by a fusion between the transcription factor binding to IGHM enhancer 3 (TFE3) gene on chromosome Xp11.2 and a partner gene on either chromosome X (c...
Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity [0.03%]
凝聚界面力重新定位DNA基因座并探测染色质粘弹性
Amy R Strom,Yoonji Kim,Hongbo Zhao et al.
Amy R Strom et al.
Biomolecular condensates assemble in living cells through phase separation and related phase transitions. An underappreciated feature of these dynamic molecular assemblies is that they form interfaces with other cellular structures, includi...
Dynamic regulation of tissue fluidity controls skin repair during wound healing [0.03%]
伤口愈合过程中动态调节组织流动性控制皮肤修复
Rahul M Sarate,Joel Hochstetter,Manon Valet et al.
Rahul M Sarate et al.
During wound healing, different pools of stem cells (SCs) contribute to skin repair. However, how SCs become activated and drive the tissue remodeling essential for skin repair is still poorly understood. Here, by developing a mouse model a...
Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment [0.03%]
阴道乳杆菌脂肪酸反应机制揭示了细菌性阴道病治疗的代谢物靶向策略
Meilin Zhu,Matthew W Frank,Christopher D Radka et al.
Meilin Zhu et al.
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus-deficient vaginal microbiota, is associated with adverse health outcomes. BV often recurs after standard antibiotic therapy in part because antibiotics promote micro...
Mining human microbiomes reveals an untapped source of peptide antibiotics [0.03%]
挖掘人类微生物组发现了一种未被开发的肽类抗生素来源
Marcelo D T Torres,Erin F Brooks,Angela Cesaro et al.
Marcelo D T Torres et al.
Drug-resistant bacteria are outpacing traditional antibiotic discovery efforts. Here, we computationally screened 444,054 previously reported putative small protein families from 1,773 human metagenomes for antimicrobial properties, identif...
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development [0.03%]
施万细胞分泌的PGE2在发育过程中促进感觉神经元兴奋性
Husniye Kantarci,Pablo D Elvira,Arun P Thottumkara et al.
Husniye Kantarci et al.
Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development and whether excitability is an intrinsic property of neurons remain unclear. Here...
High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases [0.03%]
油酰-ACP水解酶高表达导致危及生命的呼吸系统病毒感染
Xiaoxiao Jia,Jeremy Chase Crawford,Deborah Gebregzabher et al.
Xiaoxiao Jia et al.
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal dise...
Daan J Kloosterman,Johanna Erbani,Menno Boon et al.
Daan J Kloosterman et al.
Tumors growing in metabolically challenged environments, such as glioblastoma in the brain, are particularly reliant on crosstalk with their tumor microenvironment (TME) to satisfy their high energetic needs. To study the intricacies of thi...