Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition [0.03%]
TnsABCDF易位子的结构揭示了靶向DNA转座的机制
Shukun Wang,Romana Siddique,Mark C Hall et al.
Shukun Wang et al.
Tn7-like transposons are characterized by their ability to insert specifically into host chromosomes. Recognition of the attachment (att) site by TnsD recruits the TnsABC proteins to form the transpososome and facilitate transposition. Alth...
A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification [0.03%]
一种强力的泛sarbecovirus中和抗体，能够抵抗表位多样化
Laura E Rosen,M Alejandra Tortorici,Anna De Marco et al.
Laura E Rosen et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for mAbs that are resilient to epitope diversification. Broadly neu...
Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer [0.03%]
人类胰腺癌中由重复RNA引起细胞可塑性破坏的作用机制研究
Eunae You,Patrick Danaher,Chenyue Lu et al.
Eunae You et al.
Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimics viral-like responses with implications on tumor cell state and the response of the surrounding microenvironment. To better understand the relationship of r...
Guojun Wu,Ting Xu,Naisi Zhao et al.
Guojun Wu et al.
The gut microbiota is crucial for human health, functioning as a complex adaptive system akin to a vital organ. To identify core health-relevant gut microbes, we followed the systems biology tenet that stable relationships signify core comp...
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis [0.03%]
肺驻留的肺泡巨噬细胞调控乳腺癌转移的时间
Erica Dalla,Michael Papanicolaou,Matthew D Park et al.
Erica Dalla et al.
Breast disseminated cancer cells (DCCs) can remain dormant in the lungs for extended periods, but the mechanisms limiting their expansion are not well understood. Research indicates that tissue-resident alveolar macrophages suppress breast ...
Huan Zhao,Zixin Liu,Hui Chen et al.
Huan Zhao et al.
Cellular senescence plays critical roles in aging, regeneration, and disease; yet, the ability to discern its contributions across various cell types to these biological processes remains limited. In this study, we generated an in vivo gene...
Onyou Nam,Sabina Musiał,Manon Demulder et al.
Onyou Nam et al.
Diatoms are central to the global carbon cycle. At the heart of diatom carbon fixation is an overlooked organelle called the pyrenoid, where concentrated CO2 is delivered to densely packed Rubisco. Diatom pyrenoids fix approximately one-fif...
Ya Cui,Wenbin Ye,Jason Sheng Li et al.
Ya Cui et al.
Published Erratum
Cell. 2024 Oct 31;187(22):6411-6412. DOI:10.1016/j.cell.2024.09.045 2024
Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication [0.03%]
里夫谷热病毒调控可编程E3连接酶组装以促进病毒复制
Huiling Li,Yulan Zhang,Guibo Rao et al.
Huiling Li et al.
Viruses encode strategies to degrade cellular proteins to promote infection and pathogenesis. Here, we revealed that the non-structural protein NSs of Rift Valley fever virus forms a filamentous E3 ligase to trigger efficient degradation of...
Cryo-EM vs. Disease X [0.03%]
cryo-em VS疾病X
Fasséli Coulibaly
Fasséli Coulibaly
In this issue of Cell, Penzes et al. describe the use of cryo-EM to identify the cause of a mysterious disease affecting farmed superworms across the US. The study illustrates the power of ex vivo cryo-EM, which uses amplification-free samp...