Ilana Witten,Daniel L K Yamins,Claudia Clopath et al.
Ilana Witten et al.
The relationship between neuroscience and artificial intelligence (AI) has evolved rapidly over the past decade. These two areas of study influence and stimulate each other. We invited experts to share their perspectives on this exciting in...
In search of problems [0.03%]
寻找问题的人
Mu-Ming Poo
Mu-Ming Poo
With early training in physics, my career was marked by continuous learning and searching for interesting problems in biology. Here, I recount some key events that influenced my choices of research topics. The diversity of topics could be a...
Cell editorial team
Cell editorial team
Understanding the brain fascinates and intrigues many across the world. In this 50th Anniversary "Focus on Neuroscience" issue, we present Leading Edge content reflecting on the progress of the field, highlighting emerging topics, and pavin...
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer [0.03%]
Ire1α通过沉默dsRNA抑制紫杉烷诱导的焦亡以促进三阴性乳腺癌生长
Longyong Xu,Fanglue Peng,Qin Luo et al.
Longyong Xu et al.
Chemotherapy is often combined with immune checkpoint inhibitor (ICIs) to enhance immunotherapy responses. Despite the approval of chemo-immunotherapy in multiple human cancers, many immunologically cold tumors remain unresponsive. The mech...
Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target [0.03%]
多尺度药物筛选发现MD2是防治心脏纤维化的新药理靶点
Hao Zhang,Phung N Thai,Rabindra V Shivnaraine et al.
Hao Zhang et al.
Cardiac fibrosis impairs cardiac function, but no effective clinical therapies exist. To address this unmet need, we employed a high-throughput screening for antifibrotic compounds using human induced pluripotent stem cell (iPSC)-derived ca...
The multi-stage plasticity in the aggression circuit underlying the winner effect [0.03%]
胜利效应中支配行为回路的多阶段可塑性研究
Rongzhen Yan,Dongyu Wei,Avni Varshneya et al.
Rongzhen Yan et al.
Winning increases the readiness to attack and the probability of winning, a widespread phenomenon known as the "winner effect." Here, we reveal a transition from target-specific to generalized aggression enhancement over 10 days of winning ...
Structural basis of respiratory complex adaptation to cold temperatures [0.03%]
低温环境下呼吸链复合物的适应机制及其结构基础
Young-Cheul Shin,Pedro Latorre-Muro,Amina Djurabekova et al.
Young-Cheul Shin et al.
In response to cold, mammals activate brown fat for respiratory-dependent thermogenesis reliant on the electron transport chain. Yet, the structural basis of respiratory complex adaptation upon cold exposure remains elusive. Herein, we comb...
Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex [0.03%]
广谱哈奇曼抗噬菌体防御复合物的基因组完整性感应机制
Owen T Tuck,Benjamin A Adler,Emily G Armbruster et al.
Owen T Tuck et al.
Hachiman is a broad-spectrum antiphage defense system of unknown function. We show here that Hachiman is a heterodimeric nuclease-helicase complex, HamAB. HamA, previously a protein of unknown function, is the effector nuclease. HamB is the...
Xin Hou,Yong He,Pan Fang et al.
Xin Hou et al.
Current metagenomic tools can fail to identify highly divergent RNA viruses. We developed a deep learning algorithm, termed LucaProt, to discover highly divergent RNA-dependent RNA polymerase (RdRP) sequences in 10,487 metatranscriptomes ge...
Retraction notice to: hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damage [0.03%]
撤销论文：hnRNP K：HDM2靶点及DNA损伤反应中p53的转录共激活因子
Abdeladim Moumen,Philip Masterson,Mark J O&#x;Connor et al.
Abdeladim Moumen et al.
Retraction of Publication
Cell. 2024 Oct 31;187(22):6413. DOI:10.1016/j.cell.2024.10.008 2024