Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration [0.03%]
甲状腺激素重塑皮层以协调全身代谢和探索行为
Daniel R Hochbaum,Lauren Hulshof,Amanda Urke et al.
Daniel R Hochbaum et al.
Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here, we...
Memory B cell fitness and anergy has significant links to cancer lethality [0.03%]
记忆B细胞的适应性和无能与癌症致命性有显著联系
Daniel Hollern
Daniel Hollern
Two recent studies reveal that the extent of fitness or anergy in tumor-associated memory B cells is vital to anti-tumor immune response, cancer patient survival, and response to immune therapy. The impact of these seminal findings demonstr...
OLAH connects fatty acid metabolism to the severity of respiratory viral disease [0.03%]
OLAH连接脂肪酸代谢与呼吸道病毒感染严重性
Rohan Palanki,Hannah Yamagata,Michael J Mitchell
Rohan Palanki
Respiratory virus infections may cause profound respiratory illness, yet the factors that underlie disease severity are not well understood. In this issue of Cell, Jia, Crawford, et al.1 identify the role of oleoyl-ACP-hydrolase (OLAH) in m...
Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas [0.03%]
具有扰动细胞和组织图谱的因果细胞和组织生物学基础模型研究
Jennifer E Rood,Anna Hupalowska,Aviv Regev
Jennifer E Rood
Comprehensively charting the biologically causal circuits that govern the phenotypic space of human cells has often been viewed as an insurmountable challenge. However, in the last decade, a suite of interleaved experimental and computation...
Longqi Liu,Ao Chen,Yuxiang Li et al.
Longqi Liu et al.
The completion of the Human Genome Project has provided a foundational blueprint for understanding human life. Nonetheless, understanding the intricate mechanisms through which our genetic blueprint is involved in disease or orchestrates de...
Chris Xu,Maiken Nedergaard,Deborah J Fowell et al.
Chris Xu et al.
Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical imaging, particularly for studying biological tissues deep within living organisms. MPFM overcomes the strong scattering of light in heterogeneous tissue by util...
Dhrithi Deshpande,Karishma Chhugani,Tejasvene Ramesh et al.
Dhrithi Deshpande et al.
Computational data-centric research techniques play a prevalent and multi-disciplinary role in life science research. In the past, scientists in wet labs generated the data, and computational researchers focused on creating tools for the an...
In vitro human cell-based models: What can they do and what are their limitations? [0.03%]
体外人类细胞模型能做什么和不能做什么？
Matthias P Lutolf,Milica Radisic,Jeffrey Beekman et al.
Matthias P Lutolf et al.
It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations?...
Yvonne Y Chen,Charles L Evavold,Matthias Mann et al.
Yvonne Y Chen et al.
We asked researchers from a range of disciplines across biology, engineering, and medicine to describe a current technological need. The goal is to provide a sample of the various technological gaps that exist and inspire future research pr...
Cell editorial team
Cell editorial team