Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake [0.03%]
人类磷脂酰丝氨酸合成酶1的分子洞察表明其抑制可促进低密度脂蛋白摄取
Tao Long,Dongyu Li,Goncalo Vale et al.
Tao Long et al.
In mammalian cells, two phosphatidylserine (PS) synthases drive PS synthesis. Gain-of-function mutations in the Ptdss1 gene lead to heightened PS production, causing Lenz-Majewski syndrome (LMS). Recently, pharmacological inhibition of PSS1...
Structural insights into the diversity and DNA cleavage mechanism of Fanzor [0.03%]
Fanclade锌指核酸酶的结构多样性及其DNA切割机制的阐释
Peiyu Xu,Makoto Saito,Guilhem Faure et al.
Peiyu Xu et al.
Fanzor (Fz) is an ωRNA-guided endonuclease extensively found throughout the eukaryotic domain with unique gene editing potential. Here, we describe the structures of Fzs from three different organisms. We find that Fzs share a common ωRNA...
Ke Liang,Zeyu Jin,Xiechao Zhan et al.
Ke Liang et al.
Chloroplast proteins are imported via the translocon at the outer chloroplast membrane (TOC)-translocon at the inner chloroplast membrane (TIC) supercomplex, driven by an ATPase motor. The Ycf2-FtsHi complex has been identified as the chlor...
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance [0.03%]
病毒DNA聚合酶结构揭示了抗病毒药物耐药性的机制
Sundaresh Shankar,Junhua Pan,Pan Yang et al.
Sundaresh Shankar et al.
DNA polymerases are important drug targets, and many structural studies have captured them in distinct conformations. However, a detailed understanding of the impact of polymerase conformational dynamics on drug resistance is lacking. We de...
Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals [0.03%]
镶嵌沙贝科病毒纳米颗粒可诱导预接种动物产生交叉反应性免疫响应
Alexander A Cohen,Jennifer R Keeffe,Ariën Schiepers et al.
Alexander A Cohen et al.
Immunization with mosaic-8b (nanoparticles presenting 8 SARS-like betacoronavirus [sarbecovirus] receptor-binding domains [RBDs]) elicits more broadly cross-reactive antibodies than homotypic SARS-CoV-2 RBD-only nanoparticles and protects a...
Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae [0.03%]
绿藻叶绿体Ycf2-FtsHi蛋白输入机的保守性和专一性
Ke Liang,Xiechao Zhan,Yuxin Li et al.
Ke Liang et al.
The protein import motor in chloroplasts plays a pivotal role in their biogenesis and homeostasis by driving the translocation of preproteins into chloroplasts. While the Ycf2-FtsHi complex serves as the import motor in land plants, its evo...
Opposing GPCR signaling programs protein intake setpoint in Drosophila [0.03%]
GPCR信号传导程序反对果蝇蛋白质摄入设定点
Guangyan Wu,Tianji Ma,Clare E Hancock et al.
Guangyan Wu et al.
Animals defend a target level for their fundamental needs, including food, water, and sleep. Deviation from the target range, or "setpoint," triggers motivated behaviors to eliminate that difference. Whether and how the setpoint itself is e...
Animal and bacterial viruses share conserved mechanisms of immune evasion [0.03%]
动物病毒和细菌病毒具有免疫逃避的保守机制
Samuel J Hobbs,Jason Nomburg,Jennifer A Doudna et al.
Samuel J Hobbs et al.
Animal and bacterial cells sense and defend against viral infections using evolutionarily conserved antiviral signaling pathways. Here, we show that viruses overcome host signaling using mechanisms of immune evasion that are directly shared...
A line attractor encoding a persistent internal state requires neuropeptide signaling [0.03%]
一种行吸引子编码持久内部状态需要神经肽信号转导
George Mountoufaris,Aditya Nair,Bin Yang et al.
George Mountoufaris et al.
Internal states drive survival behaviors, but their neural implementation is poorly understood. Recently, we identified a line attractor in the ventromedial hypothalamus (VMH) that represents a state of aggressiveness. Line attractors can b...
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance [0.03%]
范可尼贫血信号通路诱导染色体爆炸及药物抗拒的癌基因双微体形成
Justin L Engel,Xiao Zhang,Mingming Wu et al.
Justin L Engel et al.
Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks and replication defects throughout interphase, how chromosomes undergo s...