From periphery to center stage: 50 years of advancements in innate immunity [0.03%]
从中枢到中心舞台：先天免疫50年的发展历程
Susan Carpenter,Luke A J O&#x;Neill
Susan Carpenter
Published Erratum
Cell. 2024 Nov 14;187(23):6780-6782. DOI:10.1016/j.cell.2024.10.013 2024
RNA G-quadruplexes form scaffolds that promote neuropathological α-synuclein aggregation [0.03%]
RNA G-四链体形成结构支架以促进神经病理α-突触核蛋白聚集
Kazuya Matsuo,Sefan Asamitsu,Kohei Maeda et al.
Kazuya Matsuo et al.
Synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are triggered by α-synuclein aggregation, triggering progressive neurodegeneration. However, the intracellular α-synuclein aggregati...
A conserved fertilization complex bridges sperm and egg in vertebrates [0.03%]
脊椎动物受精过程中存在一种保守的结合复合体连接精子和卵子
Victoria E Deneke,Andreas Blaha,Yonggang Lu et al.
Victoria E Deneke et al.
Fertilization, the basis for sexual reproduction, culminates in the binding and fusion of sperm and egg. Although several proteins are known to be crucial for this process in vertebrates, the molecular mechanisms remain poorly understood. U...
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes [0.03%]
PLD3和PLD4合成S,S-BMP，这是一种对溶酶体脂质降解起关键作用的磷脂
Shubham Singh,Ulrich E Dransfeld,Yohannes A Ambaw et al.
Shubham Singh et al.
Bis(monoacylglycero)phosphate (BMP) is an abundant lysosomal phospholipid required for degradation of lipids, particularly gangliosides. Alterations in BMP levels are associated with neurodegenerative diseases. Unlike typical glycerophospho...
Megan Sammons,Miranda C Popescu,Jingyi Chi et al.
Megan Sammons et al.
Behavior is tightly synchronized with bodily physiology. Internal needs from the body drive behavior selection, while optimal behavior performance requires a coordinated physiological response. Internal state is dynamically represented by t...
Pioneering discovery and therapeutics at the brain-vascular-immune interface [0.03%]
脑血管免疫界面的开拓性发现和治疗学研究
Katerina Akassoglou,Dimitrios Davalos,Andrew S Mendiola et al.
Katerina Akassoglou et al.
The brain-vascular-immune interface has emerged as a dynamic player in brain physiology and disease. We propose integrating vascular risk factors with genetic susceptibility as the nexus for the discovery of mechanisms and therapies for neu...
Joshua A Gordon,Kafui Dzirasa,Frederike H Petzschner
Joshua A Gordon
Mental illnesses arise from dysfunction in the brain. Although numerous extraneural factors influence these illnesses, ultimately, it is the science of the brain that will lead to novel therapies. Meanwhile, our understanding of this comple...
Madeline A Lancaster
Madeline A Lancaster
Evolutionary changes in human brain structure and function have enabled our specialized cognitive abilities. How these changes have come about genetically and functionally has remained an open question. However, new methods are providing a ...
Angelo Forli,Michael M Yartsev
Angelo Forli
Understanding the neural basis of natural intelligence necessitates a paradigm shift: from strict reductionism toward embracing complexity and diversity. New tools and theories enable us to tackle this challenge, providing unprecedented acc...
Mackenzie Weygandt Mathis,Adriana Perez Rotondo,Edward F Chang et al.
Mackenzie Weygandt Mathis et al.
A central principle in neuroscience is that neurons within the brain act in concert to produce perception, cognition, and adaptive behavior. Neurons are organized into specialized brain areas, dedicated to different functions to varying ext...