Hellmut G Augustin,Gou Young Koh
Hellmut G Augustin
The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endo...
Carlise Sorenson,Katarzyna P Adamala
Carlise Sorenson
Building biological computers is one of the most intensively pursued goals of modern synthetic biology. The new TriLoS tristate-based logic synthesis platform, published in this issue of Cell, offers a long-awaited solution to scale up the ...
Tian-Li Wang,Ie-Ming Shih
Tian-Li Wang
Homologous-recombination deficiency in DNA repair characterizes a unique group of cancers that are vulnerable to PARP inhibitors and cytotoxic chemotherapy. In this issue of Cell, Luo et al., demonstrated that this genetic attribute in canc...
Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases [0.03%]
现成的CAR-T细胞有望对自身免疫病的治疗产生范式转变的效果
Daniel J Baker,Carl H June
Daniel J Baker
Early reports suggest that chimeric antigen receptor (CAR)-T therapy has remarkable potential for treating autoimmune disease. Current approaches rely on autologous CAR-T cells, creating a bottleneck to the broad deployment of this therapy....
Hiten D Madhani
Hiten D Madhani
Epigenetic inheritance of heterochromatin requires transfer of parental H3-H4 tetramers to both daughter duplexes during replication. Three recent papers exploit yeast genetics coupled to inheritance assays and AlphaFold2-multimer predictio...
Brian S Kim
Brian S Kim
In defying conventional views that dismissed itch as trivial, I persisted in studying basophils and ILC2s in human skin and atopic dermatitis. My research on JAK inhibitors for itch ultimately led to FDA-approved drugs. This is my story of ...
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates [0.03%]
比较改良型安卡拉痘病毒疫苗和信使rna疫苗预防类猴痘病毒感染的保护效果研究（英文）
Eric M Mucker,Alec W Freyn,Sandra L Bixler et al.
Eric M Mucker et al.
In 2022, mpox virus (MPXV) spread worldwide, causing 99,581 mpox cases in 121 countries. Modified vaccinia Ankara (MVA) vaccine use reduced disease in at-risk populations but failed to deliver complete protection. Lag in manufacturing and d...
Comparative Study
Cell. 2024 Oct 3;187(20):5540-5553.e10. DOI:10.1016/j.cell.2024.08.043 2024
Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome [0.03%]
来自2500种食品的未被探索的微生物多样性及其与人类微生物组的关系
Niccolò Carlino,Aitor Blanco-Míguez,Michal Punčochář et al.
Niccolò Carlino et al.
Complex microbiomes are part of the food we eat and influence our own microbiome, but their diversity remains largely unexplored. Here, we generated the open access curatedFoodMetagenomicData (cFMD) resource by integrating 1,950 newly seque...
5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming [0.03%]
在合子重编程过程中，5-形式胞嘧啶是RNA Pol III的激活表观遗传标记
Eleftheria Parasyraki,Medhavi Mallick,Victoria Hatch et al.
Eleftheria Parasyraki et al.
5-Methylcytosine (5mC) is an established epigenetic mark in vertebrate genomic DNA, but whether its oxidation intermediates formed during TET-mediated DNA demethylation possess an instructive role of their own that is also physiologically r...
Cryo-EM-based discovery of a pathogenic parvovirus causing epidemic mortality by black wasting disease in farmed beetles [0.03%]
基于 cryo-em 的致病细小病毒的发现：该病毒通过黑消耗病导致养殖金龟子大规模死亡
Judit J Penzes,Martin Holm,Samantha A Yost et al.
Judit J Penzes et al.
We use cryoelectron microscopy (cryo-EM) as a sequence- and culture-independent diagnostic tool to identify the etiological agent of an agricultural pandemic. For the past 4 years, American insect-rearing facilities have experienced a disti...