Yuanhan Yang,Xiaoyong Lu,Ning Liu et al.
Yuanhan Yang et al.
In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histolog...
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival [0.03%]
TEX264通过促进DNA修复和细胞存活来驱动DNA损伤的选择性自噬
Pauline Lascaux,Gwendoline Hoslett,Sara Tribble et al.
Pauline Lascaux et al.
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of DNA lesions. We discovered that lysosomes proce...
Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics [0.03%]
单细胞基因组学揭示的痴呆共患病和特异性通路
Jessica E Rexach,Yuyan Cheng,Lawrence Chen et al.
Jessica E Rexach et al.
The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNA-seq and ATAC-seq in Alzheimer's disease (AD), frontotempo...
Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles [0.03%]
利用蛋白脂质载体安全有效地进行体内DNA和RNA输送
Douglas W Brown,Ping Wee,Prakash Bhandari et al.
Douglas W Brown et al.
Genetic medicines show promise for treating various diseases, yet clinical success has been limited by tolerability, scalability, and immunogenicity issues of current delivery platforms. To overcome these, we developed a proteolipid vehicle...
Yifan Dai,Zhengqing Zhou,Wen Yu et al.
Yifan Dai et al.
Control of the electrochemical environment in living cells is typically attributed to ion channels. Here, we show that the formation of biomolecular condensates can modulate the electrochemical environment in bacterial cells, which affects ...
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket [0.03%]
通过保守的隐蔽口袋靶向Ras、Rho和Rab家族GTP酶
Johannes Morstein,Victoria Bowcut,Micah Fernando et al.
Johannes Morstein et al.
The family of Ras-like GTPases consists of over 150 different members, regulated by an even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs) that comprise cellular switch networks that govern cell motil...
Haowu Jiang,Huan Cui,Mengyu Chen et al.
Haowu Jiang et al.
Sneezing and coughing are primary symptoms of many respiratory viral infections and allergies. It is generally assumed that sneezing and coughing involve common sensory receptors and molecular neurotransmission mechanisms. Here, we show tha...
Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy [0.03%]
衰老黑色素瘤肿瘤微环境的性别差异影响侵袭和靶向治疗抗性
Yash Chhabra,Mitchell E Fane,Sneha Pramod et al.
Yash Chhabra et al.
There is documented sex disparity in cutaneous melanoma incidence and mortality, increasing disproportionately with age and in the male sex. However, the underlying mechanisms remain unclear. While biological sex differences and inherent im...
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity [0.03%]
小分子GSDMD激动剂可激活肿瘤抗肿瘤免疫且无毒性效应
Pietro Fontana,Gang Du,Ying Zhang et al.
Pietro Fontana et al.
Gasdermin-mediated inflammatory cell death (pyroptosis) can activate protective immunity in immunologically cold tumors. Here, we performed a high-throughput screen for compounds that could activate gasdermin D (GSDMD), which is expressed w...
TGF-β and RAS jointly unmask primed enhancers to drive metastasis [0.03%]
TGF-β和RAS联合激活预备增强子以驱动转移性癌的发展
Jun Ho Lee,Francisco J Sánchez-Rivera,Lan He et al.
Jun Ho Lee et al.
Epithelial-to-mesenchymal transitions (EMTs) and extracellular matrix (ECM) remodeling are distinct yet important processes during carcinoma invasion and metastasis. Transforming growth factor β (TGF-β) and RAS, signaling through SMAD and...