The cellular dogma [0.03%]
细胞信条
Stephen R Quake
Stephen R Quake
In this essay, I will put forth what I see as a major conceptual challenge for biology in the next decade, one that is inspired by Crick's Central Dogma: understanding information flow in the cell in the most general sense. ...
From bacterial operons to gene therapy: 50 years of the journal Cell [0.03%]
从细菌操纵子到基因治疗——Cell期刊的五十年历程
Tom Maniatis
Tom Maniatis
Recombinant DNA technology has profoundly advanced virtually every aspect of biological and medical sciences, from basic research to biotechnology. Here, I discuss conceptual connections linking fundamental discoveries that were enabled by ...
Cell editorial team
Cell editorial team
Molecular biology aims to understand the details of life by focusing closely on biopolymers-DNAs, RNAs, and proteins-and how they interact with one another. Advances in this field have enabled dazzling achievements in virtually all areas of...
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations [0.03%]
粪便微生物载量是肠道菌群变异的主要决定因素和疾病关联的干扰项
Suguru Nishijima,Evelina Stankevic,Oliver Aasmets et al.
Suguru Nishijima et al.
The microbiota in individual habitats differ in both relative composition and absolute abundance. While sequencing approaches determine the relative abundances of taxa and genes, they do not provide information on their absolute abundances....
Yanhui Yu,Wenqiang Li,Yuanfang Liu et al.
Yanhui Yu et al.
Kernel dehydration rate (KDR) is a crucial production trait that affects mechanized harvesting and kernel quality in maize; however, the underlying mechanisms remain unclear. Here, we identified a quantitative trait locus (QTL), qKDR1, as a...
A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites [0.03%]
一个β-羟丁酸旁路代谢途径可以产生抗肥胖酮体代谢物
Maria Dolores Moya-Garzon,Mengjie Wang,Veronica L Li et al.
Maria Dolores Moya-Garzon et al.
β-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversion of BHB and primary energy intermediates. Here, we identify a previously undescribed BHB secondary metabolic pathw...
Decoding transcriptional identity in developing human sensory neurons and organoid modeling [0.03%]
发育中的人类感觉神经元的转录身份解析及器官样模型模拟研究
Tian Lu,Mengdi Wang,Wei Zhou et al.
Tian Lu et al.
Dorsal root ganglia (DRGs) play a crucial role in processing sensory information, making it essential to understand their development. Here, we construct a single-cell spatiotemporal transcriptomic atlas of human embryonic DRG. This atlas r...
Xiaojie Qiu,Daniel Y Zhu,Yifan Lu et al.
Xiaojie Qiu et al.
Quantifying spatiotemporal dynamics during embryogenesis is crucial for understanding congenital diseases. We developed Spateo (https://github.com/aristoteleo/spateo-release), a 3D spatiotemporal modeling framework, and applied it to a 3D m...
Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection [0.03%]
胎儿单核吞噬细胞在寨卡病毒先天性感染期间对神经侵袭与神经保护作用的差异贡献
Muhammad Abdelbasset,Wilfried A A Saron,Dongliang Ma et al.
Muhammad Abdelbasset et al.
Fetal immune cell functions during congenital infections are poorly understood. Zika virus (ZIKV) can vertically transmit from mother to fetus, causing nervous system infection and congenital ZIKV syndrome (CZS). We identified differential ...
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes [0.03%]
APOE及其脂质货物在溶酶体中的致病作用降低是通过减少APOE-受体相互作用实现的
Jing L Guo,Dylan Braun,Gabriel A Fitzgerald et al.
Jing L Guo et al.
While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the relevance of ApoE-associated lipids remain elusive. Here, we repor...