Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor [0.03%]
光诱导的phytochrome B重塑使phytochrome互作因子能够进行信号转导
Zhengdong Wang,Wenfeng Wang,Didi Zhao et al.
Zhengdong Wang et al.
Phytochrome B (phyB) and phytochrome-interacting factors (PIFs) constitute a well-established signaling module critical for plants adapting to ambient light. However, mechanisms underlying phyB photoactivation and PIF binding for signal tra...
Profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy [0.03%]
食蟹猴杜氏肌营养不良模型的细胞缺陷特征及其致病机制研究
Shuaiwei Ren,Xin Fu,Wenting Guo et al.
Shuaiwei Ren et al.
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by mutations in the DMD gene. Muscle fibers rely on the coordination of multiple cell types for repair and regenerative capacity. To elucidate the cellular and...
m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells [0.03%]
癌症细胞中m6A修饰的cenRNA稳定CENP A以保证着丝粒的完整性
Zihong Kang,Ruimeng Li,Chang Liu et al.
Zihong Kang et al.
m6A modification is best known for its critical role in controlling multiple post-transcriptional processes of the mRNAs. Here, we discovered elevated levels of m6A modification on centromeric RNA (cenRNA) in cancerous cells compared with n...
Nothing about us without us: Sharing results with communities that provide genomic data [0.03%]
没有我们，不为我们：与提供基因组数据的社区分享成果
Sarah LeBaron von Baeyer,Rebecca M Crocker,Rindra Rakotoarivony et al.
Sarah LeBaron von Baeyer et al.
Sharing genetic and other study results with the communities who participate in research falls under benefit-sharing and capacity-building initiatives that underpin a more equitable biomedical research relationship. Yet, which results to re...
A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria [0.03%]
哺乳动物线粒体中的传递性钠梯度控制膜电位
Pablo Hernansanz-Agustín,Carmen Morales-Vidal,Enrique Calvo et al.
Pablo Hernansanz-Agustín et al.
Eukaryotic cell function and survival rely on the use of a mitochondrial H+ electrochemical gradient (Δp), which is composed of an inner mitochondrial membrane (IMM) potential (ΔΨmt) and a pH gradient (ΔpH). So far, ΔΨmt has been assu...
A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease [0.03%]
参与快动眼睡眠且在帕金森病中受损的桥延环路
Mitsuaki Kashiwagi,Goichi Beck,Mika Kanuka et al.
Mitsuaki Kashiwagi et al.
Identifying the properties of the rapid eye movement (REM) sleep circuitry and its relation to diseases has been challenging due to the neuronal heterogeneity of the brainstem. Here, we show in mice that neurons in the pontine sublaterodors...
Robert A Weinberg
Robert A Weinberg
Published Erratum
Cell. 2024 Oct 17;187(21):6123. DOI:10.1016/j.cell.2024.09.010 2024
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic [0.03%]
在新冠疫情震中追踪市场野生动物和病毒的遗传痕迹
Alexander Crits-Christoph,Joshua I Levy,Jonathan E Pekar et al.
Alexander Crits-Christoph et al.
Zoonotic spillovers of viruses have occurred through the animal trade worldwide. The start of the COVID-19 pandemic was traced epidemiologically to the Huanan Seafood Wholesale Market. Here, we analyze environmental qPCR and sequencing data...
Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development [0.03%]
母乳喂养决定微生物定植程序并指导健康呼吸道发育
Liat Shenhav,Kelsey Fehr,Myrtha E Reyna et al.
Liat Shenhav et al.
Breastfeeding and microbial colonization during infancy occur within a critical time window for development, and both are thought to influence the risk of respiratory illness. However, the mechanisms underlying the protective effects of bre...
C Patrick Lusk,Megan C King
C Patrick Lusk
Nuclear pore complexes are massive protein gateways that control molecular exchange between the nucleus and cytoplasm. In this issue of Cell, Singh et al. provide the first high-resolution views of the elusive nuclear basket, which extends ...