Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses [0.03%]
基于 trellis 树的分析揭示了基质对患者衍生类器官药物反应的调节作用
María Ramos Zapatero,Alexander Tong,James W Opzoomer et al.
María Ramos Zapatero et al.
Published Erratum
Cell. 2024 Dec 12;187(25):7335-7349. DOI:10.1016/j.cell.2024.11.023 2024
Mechano-dependent sorbitol accumulation supports biomolecular condensate [0.03%]
力学依赖性的山梨醇积累支持生物分子凝聚体
Stephanie Torrino,William M Oldham,Andrés R Tejedor et al.
Stephanie Torrino et al.
Condensed droplets of protein regulate many cellular functions, yet the physiological conditions regulating their formation remain largely unexplored. Increasing our understanding of these mechanisms is paramount, as failure to control cond...
ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization [0.03%]
ACSL4和多不饱和脂质支持转移性血管外渗和定植
Yuqi Wang,Mangze Hu,Jian Cao et al.
Yuqi Wang et al.
Metastatic dissemination to distant organs demands that cancer cells possess high morphological and metabolic adaptability. However, contributions of the cellular lipidome to metastasis remain elusive. Here, we uncover a correlation between...
Atlas of the plasma proteome in health and disease in 53,026 adults [0.03%]
53,026名成人健康与疾病状态下血浆蛋白组的图谱
Yue-Ting Deng,Jia You,Yu He et al.
Yue-Ting Deng et al.
Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-...
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification [0.03%]
通过转录组范围的snoRNA靶点识别揭示的小分子核仁rna介导的蛋白质分泌机制研究
Bei Liu,Tong Wu,Bernadette A Miao et al.
Bei Liu et al.
Small nucleolar RNAs (snoRNAs) are non-coding RNAs known for guiding RNA modifications, including 2'-O-methylation (Nm) and pseudouridine (Ψ). While snoRNAs may also interact with other RNAs, such as mRNA, the full repertoire of RNAs targe...
Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems [0.03%]
褐藻作为沿海生态系统关键成分的基因组起源研究
France Denoeud,Olivier Godfroy,Corinne Cruaud et al.
France Denoeud et al.
Brown seaweeds are keystone species of coastal ecosystems, often forming extensive underwater forests, and are under considerable threat from climate change. In this study, analysis of multiple genomes has provided insights across the entir...
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer [0.03%]
肺癌中的成纤维网状细胞可生成保护性的肿瘤内T细胞微环境
Lucas Onder,Chrysa Papadopoulou,Almut Lütge et al.
Lucas Onder et al.
Stringent control of T cell activity in the tumor microenvironment is essential for the generation of protective antitumor immunity. However, the identity, differentiation, and functions of the cells that create critical fibroblastic niches...
Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation [0.03%]
类似胶质的味觉细胞介导周边甜味适应的细胞间模式
Gha Yeon Park,Geehyun Lee,Jongmin Yoon et al.
Gha Yeon Park et al.
The sense of taste generally shows diminishing sensitivity to prolonged sweet stimuli, referred to as sweet adaptation. Yet, its mechanistic landscape remains incomplete. Here, we report that glia-like type I cells provide a distinct mode o...
The Arabidopsis blue-light photoreceptor CRY2 is active in darkness to inhibit root growth [0.03%]
拟南芥蓝光受体CRY2在黑暗中活性化以抑制根系生长
Desheng Zeng,Junqing Lv,Xu Li et al.
Desheng Zeng et al.
Cryptochromes (CRYs) are blue-light receptors that regulate diverse aspects of plant growth. However, whether and how non-photoexcited CRYs function in darkness or non-blue-light conditions is unknown. Here, we show that CRY2 affects the Ar...
The single-molecule accessibility landscape of newly replicated mammalian chromatin [0.03%]
新复制的哺乳动物染色质的单分子可及性景观
Megan S Ostrowski,Marty G Yang,Colin P McNally et al.
Megan S Ostrowski et al.
We present replication-aware single-molecule accessibility mapping (RASAM), a method to nondestructively measure replication status and protein-DNA interactions on chromatin genome-wide. Using RASAM, we uncover a genome-wide state of single...