Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues [0.03%]
基于石蜡包埋组织的高通量空间研究RNA生物学
Zhiliang Bai,Dingyao Zhang,Yan Gao et al.
Zhiliang Bai et al.
The capability to spatially explore RNA biology in formalin-fixed paraffin-embedded (FFPE) tissues holds transformative potential for histopathology research. Here, we present pathology-compatible deterministic barcoding in tissue (Patho-DB...
CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease [0.03%]
基于细胞外液的蛋白质组学鉴定出了早老素基因突变型阿尔茨海默病患者早期阶段的大脑变化
Yuanyuan Shen,Jigyasha Timsina,Gyujin Heo et al.
Yuanyuan Shen et al.
In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF proteins in 286 m...
Genomic surveillance as a scalable framework for precision phage therapy against antibiotic-resistant pathogens [0.03%]
基于基因组监测的大规模精准噬菌体抗菌疗法框架
Mihály Koncz,Tamás Stirling,Hiba Hadj Mehdi et al.
Mihály Koncz et al.
Phage therapy is gaining increasing interest in the fight against critically antibiotic-resistant nosocomial pathogens. However, the narrow host range of bacteriophages hampers the development of broadly effective phage therapeutics and dem...
Dhanur P Iyer,Heidar Heidari Khoei,Vera A van der Weijden et al.
Dhanur P Iyer et al.
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathwa...
Bronze Age cheese reveals human-Lactobacillus interactions over evolutionary history [0.03%]
铜器时代的奶酪揭示了人类与乳酸菌在进化史上的相互作用
Yichen Liu,Bo Miao,Wenying Li et al.
Yichen Liu et al.
Despite the long history of consumption of fermented dairy, little is known about how the fermented microbes were utilized and evolved over human history. Here, by retrieving ancient DNA of Bronze Age kefir cheese (∼3,500 years ago) from t...
Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient [0.03%]
腹直肌鞘下移植化学诱导多能干细胞源性胰岛治疗1型糖尿病患者
Shusen Wang,Yuanyuan Du,Boya Zhang et al.
Shusen Wang et al.
We report the 1-year results from one patient as the preliminary analysis of a first-in-human phase I clinical trial (ChiCTR2300072200) assessing the feasibility of autologous transplantation of chemically induced pluripotent stem-cell-deri...
Clinical Trial
Cell. 2024 Oct 31;187(22):6152-6164.e18. DOI:10.1016/j.cell.2024.09.004 2024
Saturation mutagenesis-reinforced functional assays for disease-related genes [0.03%]
用于疾病相关基因的饱和诱变强化功能检测方法
Kaiyue Ma,Shushu Huang,Kenneth K Ng et al.
Kaiyue Ma et al.
Interpretation of disease-causing genetic variants remains a challenge in human genetics. Current costs and complexity of deep mutational scanning methods are obstacles for achieving genome-wide resolution of variants in disease-related gen...
Michael J Peluso,Steven G Deeks
Michael J Peluso
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC) defined by medically unexplained symptoms following infection with SARS-CoV-2, is a newly recognized infection-associated chron...
Emergence of community behaviors in the gut microbiota upon drug treatment [0.03%]
药物治疗后肠道微生物群中社区行为的出现
Sarela Garcia-Santamarina,Michael Kuhn,Saravanan Devendran et al.
Sarela Garcia-Santamarina et al.
Pharmaceuticals can directly inhibit the growth of gut bacteria, but the degree to which such interactions manifest in complex community settings is an open question. Here, we compared the effects of 30 drugs on a 32-species synthetic commu...
Microbial transformation of dietary xenobiotics shapes gut microbiome composition [0.03%]
饮食异物的微生物转化塑造肠道菌群组成
Elizabeth J Culp,Nora T Nelson,Andrew A Verdegaal et al.
Elizabeth J Culp et al.
Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome interactions may contribute to variation in their health consequences. To mechanistically understand these relationships, here we map interactions b...